Elucidation of the mechanism of tongue root subduction and upper airway obstruction related to the formation of pathology airway securing difficulty

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K17290
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Showa University
• Principal Investigator: tachikawa satoshi 昭和大学, 歯学部, 助教 (60781036)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: CVCI / 全身麻酔 / 経動脈灌流標本

Outline of Final Research Achievements

Under the general anesthesia, the tongue root occurs a condition called upper airway obstruction. The condition sometimes follows a fatal outcome. When the pH in the arterial blood is reduced by an increase in blood carbon dioxide (CO 2) concentration, it is known to change the respiratory rhythm. The purpose of this study was to examine how changes in respiratory rhythm are related to upper respiratory obstruction using working heart brain stem preparation. The results by an increase in blood carbon dioxide (CO2) concentration, by each muscle group constituting the upper respiratory tract is active in advance, efficient upper respiratory tract openness improvement, it has been shown to take cooperation. It was suggested that it may be an efficient and bio-change that improves hypercapnea.

Free Research Field

歯科麻酔科

Academic Significance and Societal Importance of the Research Achievements

歯科治療を行う上で全身麻酔は広く使われているが、その安全性は保証されていなければならない。全身麻酔による致死率は極めて低いが、全身麻酔導入時に人工呼吸ができなくなり（Can’t Ventilate:CV）しかも気管挿管ができなくなり、（Can’t Intubate: CI）致死的な転帰を辿ることがある。このCVCI は歯科患者にも起こりうる危険な合併症である。この状態になると速やかに低酸素血症に陥り、心停止や重篤な脳障害が引き起こされるため、解決しなければならない重要な問題となっている。本研究の学術的意義は、この病態の解明のため、重要な基礎データとして示されることになる。