2019 Fiscal Year Final Research Report
Analysis of structure and function of actin bundle in the motile ciliated cells
| Project/Area Number |
17K17701
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphology/Structure
Functional biochemistry
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
Shinohara Kyosuke 東京農工大学, 工学(系)研究科(研究院), 特任准教授 (20527387)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 繊毛 / 細胞骨格 / アクチン |
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| Outline of Final Research Achievements |
In this project, we have examined function of Dpcd protein in the mouse motile ciliated cells. Using mouse molecular genetics and in vitro reconstitutions, we have found that Dpcd organizes actin network that is involved in maturation of the mouse motile cilia. Further, Dpcd is an actin bundling protein in redox-dependent manner.
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題の成果により劣性の遺伝子性疾患である原発性繊毛運動不全症の発症メカニズムの一端が明らかとなった。まだ根本的な治療法のない疾患への治療戦略を考える上で情報を提供する。また、まだ未解明の事が多い繊毛の生物学、特に細胞骨格と繊毛の関係性を考えていく上で本研究成果は新しい知見をもたらし今後のこの分野の方向性（アクチン骨格と繊毛）に繋がる可能性がある。
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