Clarification of novel functions of the protein degradation system

2018 Fiscal Year Annual Research Report

• Project/Area Number: 17K19568
• Research Institution: Wakayama Medical University
• Principal Investigator: 改正 恒康 和歌山県立医科大学, 先端医学研究所, 教授 (60224325)
• Co-Investigator(Kenkyū-buntansha): 金澤 伸雄 和歌山県立医科大学, 医学部, 准教授 (90343227)
• Project Period (FY): 2017-06-30 – 2019-03-31
• Keywords: 炎症 / タンパク質分解 / 免疫プロテアソーム / 遺伝子変異

Outline of Annual Research Achievements

細胞内の不要あるいは不良なタンパク質は、ユビキチン化あるいは酸化を受けた後、プロテアソームと呼ばれるタンパク質複合体により分解除去される。プロテアソームは構成するサブユニットにより構成的プロテアソームあるいは免疫プロテアソームと呼ばれ、両者の違いはタンパク質の分解を担う3つのβサブユニットの違いに帰せられる（構成的プロテアソームでは、β1、β2、β5、免疫プロテアソームでは、β1i、β2i、β5i）。難治性の皮膚炎を中心とした自己炎症性疾患患者において同定された、β1iにアミノ酸置換をきたす新規のde novo変異（β1iX）をマウスに導入し、解析を行った。β1iXホモ変異マウスは生後数か月以内に死亡したが、β1iXヘテロ変異マウスは、外見上、ほぼ正常であった。しかし、β1iXヘテロ変異マウスにおいて生化学的な解析を行ったところ、未熟なβ1iの蓄積が認められ、免疫プロテアソームの形成障害が示唆された。免疫プロテアソーム機能が低下している場合には、ユビキチンや酸化タンパク質が蓄積すると考えられるが、β1iXヘテロ変異マウスにおいて、そのような蓄積はほとんど認められなかった。また、免疫学的な解析を行ったところ、胸腺の著明な縮小が認められると共に、脾臓で、CD8T細胞の減少に加えて、CD8T細胞、B細胞の減少、濾胞の形成障害が認められた。一方、骨髄においては、単球、好中球の増加が認められた。さらに解析を進めたところ、B細胞の減少は増殖の低下よりも細胞死の亢進であると考えられたが、T細胞には細胞死の亢進は認められず、生成段階の異常であることが示唆された。これらの結果から、β1iXヘテロ変異により、免疫プロテアソーム機能が何らかの機能修飾を受け、多彩な免疫異常が生じている可能性が示唆された。

Research Products

• [Int'l Joint Research] Yale Univ./Harvard Medical School/Emory Univ.(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Yale Univ./Harvard Medical School/Emory Univ.
  • # of Other Institutions: 28
• [Int'l Joint Research] Univ.of Melbourne/Australian National Univ./Telethon Kids Institute(オーストラリア)
  • Country Name: AUSTRALIA
  • Counterpart Institution: Univ.of Melbourne/Australian National Univ./Telethon Kids Institute
  • # of Other Institutions: 2
• [Int'l Joint Research] Mainz Univ./Bonn Univ./Univ. Hospital Cologne(ドイツ)
  • Country Name: GERMANY
  • Counterpart Institution: Mainz Univ./Bonn Univ./Univ. Hospital Cologne
  • # of Other Institutions: 13
• [Int'l Joint Research] London Research Institute/Imperial College/Cardiff Univ.(英国)
  • Country Name: UNITED KINGDOM
  • Counterpart Institution: London Research Institute/Imperial College/Cardiff Univ.
  • # of Other Institutions: 2
• [Int'l Joint Research] San Raffaele Scientific Institute/ICGEB(イタリア)
  • Country Name: ITALY
  • Counterpart Institution: San Raffaele Scientific Institute/ICGEB
• [Int'l Joint Research]
  • # of Other Countries: 4
• [Journal Article] A defined commensal consortium elicits CD8 T cells and anti-cancer immunity (2019)
  • Author(s): T.Tanoue, S. Morita, D.R.Plichta, A.N.Skelly, W.Suda, Y.Sugiura, S.Narushima, H.Vlamakis, I.Motoo, K.Sugita, A.Shiota, K.Takeshita, K.Yasuma, D.Riethmacher, T.Kaisho, J.M.Norman, D.Mucida, M.Suematsu, T.Yaguchi, V.Bucci, T.Inoue, Y.Kawakami, B.Olle, B.Roberts, M.Hattori, R.J.Xavier, K.Atarashi, K.Honda
  • Journal Title: Nature Volume: 565 Pages: 600～605
  • DOI: 10.1038/s41586-019-0878-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome (2019)
  • Author(s): T. Orimo, I. Sasaki, H. Hemmi, T. Ozasa, Y. Fukuda-Ohta, T. Ohta, M. Morinaka, M. Kitauchi, T. Yamaguchi, Y. Sato, T. Tanaka, K. Hoshino, K. I. Katayama, S. Fukuda, K. Miyake, M. Yamamoto, T. Satoh, K. Furukawa, E. Kuroda, K. J. Ishii, K. Takeda, T. Kaisho
  • Journal Title: International Immunology Volume: 未定 Pages: 未定
  • DOI: 10.1093/intimm/dxz004
  • Peer Reviewed / Open Access
• [Journal Article] Hyperglycemia Is Associated with Psoriatic Inflammation in Both Humans and Mice (2019)
  • Author(s): Ikumi Kyoko、Odanaka Mizuyu、Shime Hiroaki、Imai Masaki、Osaga Satoshi、Taguchi Osamu、Nishida Emi、Hemmi Hiroaki、Kaisho Tsuneyasu、Morita Akimichi、Yamazaki Sayuri
  • Journal Title: Journal of Investigative Dermatology Volume: 未定 Pages: 未定
  • DOI: 10.1016/j.jid.2019.01.029
  • Peer Reviewed
• [Journal Article] Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice (2019)
  • Author(s): Kimura Shunsuke、Kobayashi Nobuhide、Nakamura Yutaka、Kanaya Takashi、Takahashi Daisuke、Fujiki Ryoji、Mutoh Mami、Obata Yuuki、Iwanaga Toshihiko、Nakagawa Tomoo、Kato Naoya、Sato Shintaro、Kaisho Tsuneyasu、Ohno Hiroshi、Hase Koji
  • Journal Title: The Journal of Experimental Medicine Volume: 216 Pages: 831～846
  • DOI: 10.1084/jem.20181604
  • Peer Reviewed
• [Journal Article] Identification of a novel CCDC22 mutation in a patient with severe Epstein Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia (2019)
  • Author(s): Yamashita Yusuke、Nishikawa Akinori、Iwahashi Yoshifumi、Fujimoto Masakazu、Sasaki Izumi、Mishima Hiroyuki、Kinoshita Akira、Hemmi Hiroaki、Kanazawa Nobuo、Ohshima Kouichi、Imadome Ken-Ichi、Murata Shin-ichi、Yoshiura Koh-ichiro、Kaisho Tsuneyasu、Sonoki Takashi、Tamura Shinobu
  • Journal Title: International Journal of Hematology Volume: 未定 Pages: 未定
  • DOI: 10.1007/s12185-019-02595-0
  • Peer Reviewed
• [Journal Article] Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9-genome editing promotes antitumor immunity and suppresses ovarian cacer progression (2019)
  • Author(s): Yahata Tamaki、Mizoguchi Mika、Kimura Akihiko、Orimo Takashi、Toujima Saori、Kuninaka Yumi、Nosaka Mizuho、Ishida Yuko、Sasaki Izumi、Fukuda‐Ohta Yuri、Hemmi Hiroaki、Iwahashi Naoyuki、Noguchi Tomoko、Kaisho Tsuneyasu、Kondo Toshikazu、Ino Kazuhiko
  • Journal Title: Cancer Science Volume: 110 Pages: 1279～1292
  • DOI: 10.1111/cas.13958
  • Peer Reviewed / Open Access
• [Journal Article] Induced pluripotent stem cells representing Nakajo-Nishimura syndrome (2019)
  • Author(s): Kanazawa Nobuo、Honda-Ozaki Fumiko、Saito Megumu K.
  • Journal Title: Inflammation and Regeneration Volume: 39 Pages: 11
  • DOI: 10.1186/s41232-019-0099-8
  • Peer Reviewed / Open Access
• [Journal Article] Beneficial effect of methotrexate on a child case of Nakajo-Nishimura syndrome (2019)
  • Author(s): Kunimoto Kayo、Honda‐Ozaki Fumiko、Saito Megumu K.、Furukawa Fukumi、Kanazawa Nobuo
  • Journal Title: The Journal of Dermatology Volume: 未定 Pages: 未定
  • DOI: 10.1111/1346-8138.14907
  • Peer Reviewed / Open Access
• [Journal Article] Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis (2019)
  • Author(s): Hara Tomoyuki、Ikeda Takaharu、Inaba Yutaka、Kunimoto Kayo、Mikita Naoya、Kaminaka Chikako、Kanazawa Nobuo、Yamamoto Yuki、Tabata Kayoko、Fujii Takao、Jinnin Masatoshi
  • Journal Title: The Journal of Dermatology Volume: 46 Pages: 334～337
  • DOI: 10.1111/1346-8138.14774
  • Peer Reviewed
• [Journal Article] CO2 narcosis as a notable cause of premature death in Nakajo-Nishimura syndrome (2019)
  • Author(s): Kanazawa Nobuo、Hara Mariko、Hara Tomoyuki、Kunimoto Kayo、Mikita Naoya、Furukawa Fukumi
  • Journal Title: Modern Rheumatology Case Reports Volume: 3 Pages: 74～78
  • DOI: 10.1080/24725625.2018.1524540
• [Journal Article] Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner (2018)
  • Author(s): Gopinath Smita、Kim Myoungjoo V.、Rakib Tasfia、Wong Patrick W.、van Zandt Michael、Barry Natasha A.、Kaisho Tsuneyasu、Goodman Andrew L.、Iwasaki Akiko
  • Journal Title: Nature Microbiology Volume: 3 Pages: 611～621
  • DOI: 10.1038/s41564-018-0138-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles (2018)
  • Author(s): Kayama Hisako、Kohyama Masako、Okuzaki Daisuke、Motooka Daisuke、Barman Soumik、Okumura Ryu、Muneta Masato、Hoshino Katsuaki、Sasaki Izumi、Ise Wataru、Matsuno Hiroshi、Nishimura Junichi、Kurosaki Tomohiro、Nakamura Shota、Arase Hisashi、Kaisho Tsuneyasu、Takeda Kiyoshi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Pages: 8418～8423
  • DOI: 10.1073/pnas.1808426115
  • Peer Reviewed / Open Access
• [Journal Article] XCR1+樹状細胞による腸管免疫制御機構 (2018)
  • Author(s): 小笹俊哉、改正恒康
  • Journal Title: 医学のあゆみ Volume: 265(13) Pages: 1241～1247
• [Journal Article] 生体内における樹状細胞への腫瘍抗原送達システムによる新規がんペプチドワクチン療法 (2018)
  • Author(s): 水本有紀、勝田将裕、宮澤基樹、北畑裕司、宮本篤、中森幹人、尾島敏康、松田健司、邊見弘明、玉田耕治、改正恒康、山上裕機
  • Journal Title: 癌と化学療法 Volume: 45 Pages: 1469～1471
• [Journal Article] Antinuclear antibodies in Nakajo-Nishimura syndrome. A bridge with research on refractory autoimmune diseases (2018)
  • Author(s): Inaba Y、 Kanazawa N、Kunimoto K、 Furukawa F
  • Journal Title: Trends in Immunotherapy Volume: 2 Pages: 1078
  • DOI: 10.24294/ti.v2.i3.1078
  • Peer Reviewed / Open Access
• [Journal Article] Effects of a humanized anti-human IL-6 receptor monocle antibody on Nakajo-Nishimura syndrome (2018)
  • Author(s): Inaba Y, Kunimoto K, Kanazawa N, Furukawa F
  • Journal Title: Trends Immunotherapy Volume: 2 Pages: 1051
  • Peer Reviewed
• [Journal Article] Prognostic factors of daily blood examination for advanced melanoma patients treated with nivolumab (2018)
  • Author(s): Okuhira Hisako、Yamamoto Yuki、Inaba Yutaka、Kunimoto Kayo、Mikita Naoya、Ikeda Takaharu、Kaminaka Chikako、Minami Yoshimi、Kanazawa Nobuo、Furukawa Fukumi、Jinnin Masatoshi
  • Journal Title: BioScience Trends Volume: 12 Pages: 412～418
  • DOI: 10.5582/bst.2018.01158
  • Peer Reviewed
• [Journal Article] Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress (2018)
  • Author(s): Honda-Ozaki Fumiko、Terashima Madoka、Niwa Akira、Saiki Norikazu、Kawasaki Yuri、Ito Haruna、Hotta Akitsu、Nagahashi Ayako、Igura Koichi、Asaka Isao、Li Hongmei Lisa、Yanagimachi Masakatsu、Furukawa Fukumi、Kanazawa Nobuo、Nakahata Tatsutoshi、Saito Megumu K.
  • Journal Title: Stem Cell Reports Volume: 10 Pages: 1835～1850
  • DOI: 10.1016/j.stemcr.2018.04.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Repeated hyperhidrosis and chilblain-like swelling with ulceration of the fingers and toes in hereditary sensory and autonomic neuropathy type II (2018)
  • Author(s): Shima Tomoko、Yamamoto Yuki、Kanazawa Nobuo、Murata Ken-ya、Ito Hidefumi、Kondo Toshikazu、Yuan Junhui、Hashiguchi Akihiro、Takashima Hiroshi、Furukawa Fukumi
  • Journal Title: The Journal of Dermatology Volume: 45 Pages: e308～e309
  • DOI: 10.1111/1346-8138.14336
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel PSTPIP1 gene mutation in pyoderma gangrenosum, acne and suppurative hidradenitis syndrome (2018)
  • Author(s): Saito Nao、Minami-Hori Masako、Nagahata Hiroko、Nozaki Hiroyoshi、Iinuma Shin、Igawa Satomi、Kanno Kyoko、Kishibe Mari、Kanazawa Nobuo、Ishida-Yamamoto Akemi
  • Journal Title: The Journal of Dermatology Volume: 45 Pages: e213～e214
  • DOI: 10.1111/1346-8138.14259
  • Peer Reviewed
• [Journal Article] Combination use of triamcinolone acetonide and immunotherapy as a new therapeutic option in alopecia totalis (2018)
  • Author(s): Yoshimasu Takashi、Mikita Naoya、Ikeda Takaharu、Kanazawa Nobuo、Furukawa Fukumi、Jinnin Masatoshi
  • Journal Title: Trends in Immunotherapy Volume: 2 Pages: 149
  • DOI: 10.24294/ti.v2.i1.149
  • Peer Reviewed / Open Access
• [Journal Article] Severer lupus erythematosus-like skin lesions in MRL/lpr mice with homozygous Kitwsh/wsh mutation (2018)
  • Author(s): Inaba Yutaka、Kanazawa Nobuo、Yoshimasu Takashi、Shimokawa Toshio、Nosaka Mizuho、Kondo Toshikazu、Furukawa Fukumi
  • Journal Title: Modern Rheumatology Volume: 28 Pages: 319～326
  • DOI: 10.1080/14397595.2017.1341591
  • Peer Reviewed / Open Access
• [Journal Article] 肺炎・呼吸不全の加療中にテオドール（テオフィリン）によるスティーブンス・ジョンソン症候群を発症し死亡した１例 (2018)
  • Author(s): 濱本千晶、国本佳代、早田敦志、石本淳也、古川福実、神人正寿、金澤伸雄
  • Journal Title: 和歌山医学 Volume: 69 Pages: 61～65
• [Journal Article] 尋常性乾癬に対するブロダルマブ治験中に肺化膿症を生じた１例 (2018)
  • Author(s): 10.川口亜美、国本佳代、三木田直哉、神人正寿、金澤伸雄
  • Journal Title: 臨床皮膚科 Volume: 72 Pages: 763～769
• [Journal Article] クリオピリン関連周期熱症候群（CAPS）と自己炎症性疾患 (2018)
  • Author(s): 金澤伸雄
  • Journal Title: 皮膚科医会雑誌 Volume: - Pages: 35848～35853
• [Journal Article] プロテアソーム関連自己炎症性症候群－中條－西村症候群と関連疾患 (2018)
  • Author(s): 13.金澤伸雄
  • Journal Title: 医学のあゆみ Volume: 267 Pages: 689～695
• [Journal Article] プロテアソーム関連自己炎症性症候群（中條－西村症候群を中心に） (2018)
  • Author(s): 金澤伸雄
  • Journal Title: 日本臨牀 Volume: 76 Pages: 1777～1784
• [Journal Article] 凍瘡様皮疹を呈する自己炎症性疾患 (2018)
  • Author(s): 原知之、金澤伸雄
  • Journal Title: 西日本皮膚科 Volume: 80 Pages: 321～326
  • DOI: 10.2336/nishinihonhifu.80.321
• [Journal Article] 中條－西村症候群 (2018)
  • Author(s): 金澤伸雄
  • Journal Title: リウマチ科 Volume: 59 Pages: 463～469
• [Presentation] Analysis of mice carrying a novel mutation in a proteasome subunit gene identifed in an autoinammatory disease patient (2019)
  • Author(s): 金澤伸雄、小笹俊哉、邊見弘明、加藤喬、折茂貴是、佐々木泉、福田(大田)有里、改正恒康、木下晃、吉浦孝一郎、金城紀子、水島恒裕
  • Organizer: 第2回日本免疫不全・自己炎症学会総会・学術集会
• [Presentation] 乳児期発症の繰り返す凍瘡様紅斑の精査でTREX1遺伝子変異を認めFamilial chilblain lupusと診断した1男児例 (2019)
  • Author(s): 江波戸孝輔、金澤伸雄、坂東由紀
  • Organizer: 第2回日本免疫不全・自己炎症学会総会・学術集会
• [Presentation] FAS遺伝子のcompound heterozygous frameshift mutationを有する腸管MALTリンパ腫の若年例 (2019)
  • Author(s): 小浴秀樹、山下友佑、田村志宣、園木孝志、金澤伸雄、大島孝一、三嶋博之、木下晃、吉浦孝一郎
  • Organizer: 第2回日本免疫不全・自己炎症学会総会・学術集会
• [Presentation] 皮膚科医に知っていただきたい樹状細胞の機能的および病理的意義 (2018)
  • Author(s): 改正恒康、邊見弘明、小笹俊哉
  • Organizer: 第117回日本日本皮膚科学会総会
  • Invited
• [Presentation] プロテアソーム関連自己炎症性症候群のマウスモデル (2018)
  • Author(s): 改正恒康、邊見弘明、金澤伸雄、加藤喬、稲葉豊、小笹俊哉
  • Organizer: 第39回日本炎症・再生学会
  • Invited
• [Presentation] Current overview of functions and development of dendritic cells (2018)
  • Author(s): Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会
  • Invited
• [Presentation] 中條－西村症候群からプロテアソーム関連自己炎症/免疫不全症候群へ (2018)
  • Author(s): 金澤伸雄、中谷友美、原知之、稲葉豊、国本佳代、古川福実、神人正寿、金城紀子、水島恒裕、三嶋博之、木下晃、吉浦孝一郎、加藤喬、福田有里、邊見弘明、改正恒康
  • Organizer: 第25回分子皮膚科学フォーラム
• [Presentation] 新規LIG4遺伝子変異を導入したLIG4症候群モデルマウス A mouse model of LIG4 syndrome with novel LIG4 mutation (2018)
  • Author(s): 山下友佑、田村志宣、福田有里、小笹俊哉、金澤伸雄、邊見弘明、吉浦孝一郎、改正恒康、園木孝志
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Impaired development of dendritic cells in proteasome subunit mutant mice (2018)
  • Author(s): Hiroaki Hemmi, Toshiya Ozasa, Akira Kinoshita, Takashi Kato, Takashi Orimo, Izumi Sasaki, Yuri Fukuda-Ohta, Noriko Kinjo, Koh-Ichiro Yoshiura, Tsunehiro Mizushima,Nobuo Kanazawa, Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Cholera toxin B can induce interleukine-1β production in peritoneal macrophages through activation of pyrin inflammasome (2018)
  • Author(s): Izumi Sasaki, Takashi Orimo, Hiroaki Hemmi, Toshiya Ozasa, Yuri Fukuda-Ohta, Mio Morinaka, Shinji Fukuda, Koichi Furukawa, Etsushi Kuroda, Ken J. Ishii, Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] The mechanism of action of Spi-B in transcriptional activation of the interferon-α4 gene (2018)
  • Author(s): Ryo Miyazaki, Hiroyuki Saiga, Tsuneyasu Kaisho, Katsuaki Hoshino
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Cancer Vaccine Composed of Whole Tumor Cells Genetically Modified to Secrete the XCL1 (2018)
  • Author(s): Atsushi Miyamoto, Hemmi Hiroaki, Yuki Mizumoto, Masahiro Katsuda, Yuri Ohta,Katsuaki Hoshino, Hiroki Yamaue, Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Dendritic cells expressing a unique set of genes associated with immunological tolerance are specialized to expand thymus-derived Foxp3+ regulatory T cells in the ultraviolet B-exposed skin (2018)
  • Author(s): Sayuri Yamazaki, Mizuyu Odanaka, Akiko Nishioka, Hiroaki Shime, Hiroaki Hemmi,Masaki Imai, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Hyperglycemia is associated with psoriatic inflammation in both humans and mice (2018)
  • Author(s): Mizuyu Odanaka, Kyoko Ikumi, Hiroaki Shime, Masaki Imai, Hiroaki Hemmi, Tsuneyasu Kaisho, Akimichi Morita, Sayuri Yamazaki
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Sox8 is essential for the differentiation of M cells and antigen-specific IgA response (2018)
  • Author(s): Nobuhide Kobayashi, Shunsuke Kimura, Yutaka Nakamura, Takashi Kanaya, Tsuneyasu Kaisho, Hiroshi Ohno, Koji Hase
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Osteoprotegerin-dependent M-cell self-regulation balances gut infection and immunity (2018)
  • Author(s): Shunsuke Kimura, Yutaka Nakamura, Nobuhide Kobayashi, Tsuneyasu Kaisho, Koji Hase
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] M-cell-dependent antigen uptake mitigates infectious colitis by shaping mucosal barrier function (2018)
  • Author(s): Yutaka Nakamura, Hitomi Mimuro, Jun Kunisawa, Tsuneyasu Kaisho, Hiroshi Kiyono, Koji Hase
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] A case of neonatal-onset proteasome-associated autoinflammatory syndrome resembling but distinct from Nakajo-Nishimura syndrome (2018)
  • Author(s): Noriko Kinjo, Hiroyuki Mishima, Akira Kinoshita, Koh-Ichiro Yoshiura,Tsunehiro Mizushima, Jun Hamazaki, Shigeo Murata, Hiroaki Hemmi, Tsuneyasu Kaisho,Nobuo Kanazawa
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Analysis of mice carrying a novel mutation in a proteasome subunit gene identified in anautoinflammatory disease patient (2018)
  • Author(s): Toshiya Ozasa, Hiroaki Hemmi, Akira Kinoshita, Takashi Kato, Takashi Orimo, Izumi Sasaki, Yuri Fukuda-Ohta, Noriko Kinjo, Koh-Ichiro Yoshiura, Tsunehiro Mizushima, Nobuo Kanazawa, Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] XCR1+DCへの選択的な送達を目的とした新規抗がんワクチンの開発 (2018)
  • Author(s): 宮本篤、勝田将裕、邊見弘明、宮澤基樹、北畑裕司、水本有紀、小林良平、改正恒康、山上裕機
  • Organizer: 第46回和歌山悪性腫瘍研究会
• [Presentation] CRISPR/Cas9による腫瘍上のPD-L1欠損はマウス卵巣癌モデルにおいて抗腫瘍免疫を促進し、腫瘍進展を抑制する (2018)
  • Author(s): 八幡環、岩橋尚幸、野口智子、溝口美佳、東嶋左緒里、改正恒康、近藤稔和、井篦一彦
  • Organizer: 第46回和歌山悪性腫瘍研究会
• [Presentation] Immune regulation by a dendritic cell subset expressing a chemokine receptor, XCR1 (2018)
  • Author(s): Tsuneyasu Kaisho
  • Organizer: 15th International Symposium on Dendritic Cells
  • Int'l Joint Research / Invited
• [Presentation] Foxp3+ regulatory T cells are expanded by ultraviolet B-exposed PD-L1+ skin dendritic cell expressing a unique set of genes in a CSF1-independent manner (2018)
  • Author(s): Sayuri Yamazaki, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Akiko Nishioka, Saori Kasuya, Dieter Riethmacher, Hiroaki Hemmi, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
  • Organizer: International Investigative Dermatology 2018
  • Int'l Joint Research / Invited
• [Presentation] Successful treatment of psoriatic inflammation restores hyperglycemia (2018)
  • Author(s): Kyoko Ikumi, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Osamu Taguchi, Hiroaki Hemmi, Tsuneyasu Kaisho, Sayuri Yamazaki, Akimichi Morita
  • Organizer: International Investigative Dermatology 2018
  • Int'l Joint Research
• [Presentation] Time-resolved systems analysis of virus infection fate regulation: the XCL1-XCR1 communication axis links T cell exhaustion with effector maintenance (2018)
  • Author(s): J. Argilaguet, M. Pedragosa, A. Esteve-Codina, G. Riera, E. Vidal, C. Peligero-Cruz, D. Andreu, T. Kaisho, G. Bocharov, B. Ludewig, S. Heath, A. Meyerhans
  • Organizer: 15th International Symposium on Dendritic Cells
  • Int'l Joint Research
• [Presentation] Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections (2018)
  • Author(s): Chikako Shimokawa, Takashi Kanaya, Masami Hachisuka, Kenji Ishiwata, Hajime Hisaeda, Yosuke Kurashima, Hiroshi Kiyono, Tomohiro Yoshimoto, Tsuneyasu Kaisho, Hiroshi Ohno
  • Organizer: The 3rd International Conference on Innate Lymphoid Cells (ILC2018)
  • Int'l Joint Research
• [Presentation] クリオピリン関連周期熱症候群（CAPS）と自己炎症性疾患 (2018)
  • Author(s): 金澤伸雄
  • Organizer: 第34回日本臨床皮膚科医会総会・学術大会
• [Presentation] iPS細胞を用いた中條－西村症候群の病態解明と治療薬開発の試み (2018)
  • Author(s): 金澤伸雄、尾崎富美子、寺嶋聖佳、丹羽明、柳町昌克、古川福実、中畑龍俊、斎藤潤
  • Organizer: 第117回日本皮膚科学会総会
• [Presentation] iPS細胞を用いた中條－西村症候群の病態解明と治療薬開発の試み (2018)
  • Author(s): 金澤伸雄、尾崎富美子、寺嶋聖佳、丹羽明、柳町昌克、古川福実、中畑龍俊、斎藤潤
  • Organizer: 第39回日本炎症・再生医学会
• [Presentation] 自己炎症性疾患アップデート (2018)
  • Author(s): 金澤伸雄
  • Organizer: 第42回日本小児皮膚科学会学術大会
• [Presentation] 遺伝性自己炎症性皮膚疾患の全国皮膚科疫学調査結果のまとめ (2018)
  • Author(s): 金澤伸雄、中谷友美、原知之、稲葉豊、国本佳代、古川福実、神人正寿
  • Organizer: 第70回日本皮膚科学会西部支部学術大会
• [Presentation] 自己炎症症候群をめぐる最新の話題 (2018)
  • Author(s): 金澤伸雄
  • Organizer: 第48回日本皮膚免疫アレルギー学会総会学術大会
• [Presentation] Pluripotent stem cell model of Nakajo-Nishimura syndrome untangles proinflammatory pathways mediated by oxidative stress (2018)
  • Author(s): Kanazawa N, Honda-Ozaki F, Terashima M, Niwa A, Yanagimachi M, Furukawa F, Nakahata T, Saito MK
  • Organizer: International Investigative Dermatology
  • Int'l Joint Research
• [Presentation] Comparative immunohistochemical study of the skin lesions of Nakajo-Nishimura syndrome and PSMB9-related proteasome-associated autoinflammatory syndrome with cutaneous adverse reactions induced by a proteasome inhibitor (2018)
  • Author(s): Kunimoto K, Inaba Y, Nakatani Y, Kinjo N, Kinoshita A, Yoshiura K, Jinnin M, Kanazawa N
  • Organizer: International Investigative Dermatology
  • Int'l Joint Research
• [Presentation] A Japanese family of PASH (pyoderma gangrenosum, acne and suppurative hidradenitis) syndrome with a distinct PSTPIP1 mutation and review of related syndromes, PAPA, PAMI, PAPASH, PsAPASH, PASS, and PAC (2018)
  • Author(s): Kanazawa N, Saito N, Igawa S, Kishibe M, Ishida-Yamamoto A
  • Organizer: 13th Meeting of the German-Japanese Society for Dermatology
  • Int'l Joint Research
• [Presentation] Clinical and pathological features in patients with Nakajo-Nishimura syndrome and inclusion body myositis (2018)
  • Author(s): Mori M, Kanazawa N, Kunimoto K, Murata K, Ito H
  • Organizer: The 19d International Congress of Neuropathology
  • Int'l Joint Research