Development of novel biodesign mice by epistasis

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K19683
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Internal medicine of the bio-information integration and related fields
• Research Institution: Osaka University
• Principal Investigator: YAGI Takeshi 大阪大学, 生命機能研究科, 教授 (10241241)
• Research Collaborator: UCHIMURA Arikuni ; HIGUCHI Mayumi
• Project Period (FY): 2017-06-30 – 2019-03-31
• Keywords: 突然変異 / 疾患モデル / マウス / 遺伝子 / 多因子疾患 / 量的形質

Outline of Final Research Achievements

This project aims to develop novel biodesigned mice by epistasis and to understand gene mutations caused of quantitive phenotypes and Multifactorial diseases. To achieve the goal, we produced hyper mutation mouse strains, and then repeated the passage of their mouse strains.
We are successful to obtain a lot of mouse strains with visible phenotypes and perform whole genome sequencing of thier mouse strains by next generations sequencer.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

本研究では、体重、体長、出産数などの量的形質の違いがあるマウス系統が得られ、量的形質をもたらす遺伝子変異について解析できるマウスモデルシステムができた。また、糖尿病、心疾患、血圧、行動に異常のあるマウス系統が得られたことから多因子疾患モデルが得られ、遺伝子変異の解析ができれば、原因遺伝子の発見や疾患への新たな治療法の開発に繋がることが期待される。