Elucidation of the new control mechanism of aging through PAI-1

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K19881
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Health science and related fields
• Research Institution: Tohoku University
• Principal Investigator: Dan Takashi 東北大学, 医学系研究科, 准教授 (00512451)
• Project Period (FY): 2017-06-30 – 2019-03-31
• Keywords: 老化制御 / PAI-1 / TNFα

Outline of Final Research Achievements

As a result of examining the influence of PAI-1 on the transcription of TNFα of SASP (cellular senescence related secretory trait), the new physiological action of PAI-1 which has not been reported so far has been reported that PAI-1 directly enhances macrophage cytokine expression I found it. This action is completely different from conventionally known fibrinolytic control.

Free Research Field

創薬科学

Academic Significance and Societal Importance of the Research Achievements

化合物（仮称CompoundX）がPAI-1で誘導されるTNFα産生を抑制することの発見は、新薬創製のシーズとなり、新しい機序の抗炎症剤や抗がん剤の研究開発につながる。