Do microbiomes involve in the toxicological mechanisms of Pb in low concentration / long term chronic Pb exposure?

2021 Fiscal Year Annual Research Report

• Project/Area Number: 17KK0009
• Research Institution: Hokkaido University
• Principal Investigator: 中山 翔太 北海道大学, 獣医学研究院, 准教授 (90647629)
• Project Period (FY): 2018 – 2021
• Keywords: 鉛汚染 / 腸内細菌叢 / 低濃度暴露 / 慢性暴露 / 毒性発現 / カブウェ鉱床 / 次世代シークエンス解析 / フォロアップ研究

Outline of Annual Research Achievements

高濃度の鉛汚染が明らかになっているザンビア国・カブエ鉱床地域において、10歳未満の子供約600名、1歳未満の母子440組（880名）を対象に血液、尿、糞便を採取し、血液中鉛濃度の解析を実施した。母子の血液、母乳、乳幼児の糞便中の鉛濃度および同位体分析により、乳幼児における鉛暴露経路の評価を行ない、土壌や粉塵による寄与が大きいことを解明した。鉛暴露が腸内細菌叢に及ぼす影響の解析を進めた。さらに、血中・尿中・糞便中の鉛濃度に加えて、マグネシウム、マンガン、鉄、カドミウム、ヒ素、銅、亜鉛などの他の金属濃度も分析し、鉛以外による腸内細菌叢への影響を統合的に解析することを試みている。さらに、約1250名を対象に実施した血液鉛濃度の解析や、主成分分析や判別解析、重回帰分析などの多変量解析手法によるデータマイニングを行い、どの要因が複合的に影響を及ぼしているのか解明し、肝臓や腎臓などの臓器毒性パラメーターやゲノムメチル化との統計的に有意な負の影響を解明し、複数の学術論文に受理された。さらに、鉛暴露によるALADおよびp16遺伝子プロモーターにおけるDNAメチル化、ALADおよびビタミンD受容体関連遺伝子の遺伝子多型について解明した。鉛によるエピジェネティックな変化についての知見は限定的で、これらの成果は鉛毒性の発現機序の解明に貢献する。健康関連生活の質（Quality of Life: QOL）と血中鉛濃度の関連性についてもアフリカで初めて解析を行い、母親のQOLが子供の鉛暴露により影響を受けることを明らかにしたという点で、学術的に重要な知見となった。我々の成果は、World Bankなどの国際機関にもデータ提供を行っている。実際にWorld Bankが実施する同地域のプロジェクトにおいて、我々のデータをもとに住民に対する血中鉛濃度を低下させるキレート剤治療が行われた。

Research Products

• [Int'l Joint Research] ザンビア大学(ザンビア) (2022)
  • Year and Date: 2022-01-29 – 2022-02-10
  • Country Name: ZAMBIA
  • Counterpart Institution: ザンビア大学
  • Co-investigator Overseas: John Yabe
  • Department: 獣医学部
  • Job Title: 講師
• [Int'l Joint Research] ザンビア大学(ザンビア) (2021)
  • Year and Date: 2021-10-02 – 2021-10-21
  • Country Name: ZAMBIA
  • Counterpart Institution: ザンビア大学
  • Co-investigator Overseas: John Yabe
  • Department: 獣医学部
  • Job Title: 講師
• [Int'l Joint Research] ザンビア大学(ザンビア) (2021)
  • Year and Date: 2021-02-01 – 2021-03-01
  • Country Name: ZAMBIA
  • Counterpart Institution: ザンビア大学
  • Co-investigator Overseas: John Yabe
  • Department: 獣医学部
  • Job Title: 講師
• [Int'l Joint Research] ザンビア大学(ザンビア) (2018)
  • Year and Date: 2018-08-10 – 2018-09-15 | 2019-02-262019-03-26 | 2019-08-102019-09-15 | 2020-02-262020-03-26 | 2020-08-152020-09-15
  • Country Name: ZAMBIA
  • Counterpart Institution: ザンビア大学
  • Co-investigator Overseas: John Yabe
  • Department: 獣医学部
  • Job Title: 講師
• [Journal Article] Human Health Risk Assessment from Lead Exposure through Consumption of Raw Cow Milk from Free-Range Cattle Reared in the Vicinity of a Lead/Zinc Mine in Kabwe (2022)
  • Author(s): Zyambo Golden、Yabe John、Muzandu Kaampwe、M’kandawire Ethel、Choongo Kennedy、Kataba Andrew、Chawinga Kenneth、Liazambi Allan、Nakayama Shouta M. M、Nakata Hokuto、Ishizuka Mayumi
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 19 Pages: 4757～4757
  • DOI: 10.3390/ijerph19084757
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Alkaline Leaching and Concurrent Cementation of Dissolved Pb and Zn from Zinc Plant Leach Residues (2022)
  • Author(s): Silwamba Marthias、Ito Mayumi、Hiroyoshi Naoki、Tabelin Carlito Baltazar、Hashizume Ryota、Fukushima Tomoki、Park Ilhwan、Jeon Sanghee、Igarashi Toshifumi、Sato Tsutomu、Nyambe Imasiku、Nakata Hokuto、Nakayama Shouta、Ishizuka Mayumi
  • Journal Title: Minerals Volume: 12 Pages: 393～393
  • DOI: 10.3390/min12040393
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Geochemical identification of particulate lead pollution in shallow groundwater in inhabited areas in Kabwe, Zambia (2022)
  • Author(s): Toyoda Kazuhiro、Nakano Shota、Tanaka Shunitz、Banda Kawawa、Nyambe Imasiku A.、Ishikawa Tsuyoshi、Nakayama Shouta、Ishizuka Mayumi
  • Journal Title: Applied Geochemistry Volume: 139 Pages: 105215～105215
  • DOI: 10.1016/j.apgeochem.2022.105215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead: A Preliminary Study (2022)
  • Author(s): Nakata Hokuto、Eguchi Akifumi、Nakayama Shouta M. M.、Yabe John、Muzandu Kaampwe、Ikenaka Yoshinori、Mori Chisato、Ishizuka Mayumi
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 19 Pages: 541～541
  • DOI: 10.3390/ijerph19010541
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Geospatial approach to investigate spatial clustering and hotspots of blood lead levels in children within Kabwe, Zambia (2022)
  • Author(s): Moonga Given、Chisola Moses N.、Berger Ursula、Nowak Dennis、Yabe John、Nakata Hokuto、Nakayama Shouta、Ishizuka Mayumi、Bose-O'Reilly Stephan
  • Journal Title: Environmental Research Volume: 207 Pages: 112646～112646
  • DOI: 10.1016/j.envres.2021.112646
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Environmentally relevant lead (Pb) water concentration induce toxicity in zebrafish (Danio rerio) larvae (2022)
  • Author(s): Kataba Andrew、Botha Tarryn L.、Nakayama Shouta M.M.、Yohannes Yared B.、Ikenaka Yoshinori、Wepener Victor、Ishizuka Mayumi
  • Journal Title: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology Volume: 252 Pages: 109215～109215
  • DOI: 10.1016/j.cbpc.2021.109215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Solid-Phase Partitioning and Leaching Behavior of Pb and Zn from Playground Soils in Kabwe, Zambia (2021)
  • Author(s): Mufalo Walubita、Tangviroon Pawit、Igarashi Toshifumi、Ito Mayumi、Sato Tsutomu、Chirwa Meki、Nyambe Imasiku、Nakata Hokuto、Nakayama Shouta、Ishizuka Mayumi
  • Journal Title: Toxics Volume: 9 Pages: 248～248
  • DOI: 10.3390/toxics9100248
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of zinc on tissue uptake and toxicity of lead in Sprague Dawley rat (2021)
  • Author(s): KATABA Andrew、NAKAYAMA Shouta M.M.、YOHANNES Yared Beyene、TOYOMAKI Haruya、NAKATA Hokuto、IKENAKA Yoshinori、ISHIZUKA Mayumi
  • Journal Title: Journal of Veterinary Medical Science Volume: 83 Pages: 1674～1685
  • DOI: 10.1292/jvms.20-0684
  • Peer Reviewed / Open Access
• [Journal Article] Glutathione S-transferase gene polymorphisms in association with susceptibility to lead toxicity in lead- and cadmium-exposed children near an abandoned lead-zinc mining area in Kabwe, Zambia (2021)
  • Author(s): Yohannes Yared Beyene、Nakayama Shouta M. M.、Yabe John、Toyomaki Haruya、Kataba Andrew、Nakata Hokuto、Muzandu Kaampwe、Ikenaka Yoshinori、Choongo Kennedy、Ishizuka Mayumi
  • Journal Title: Environmental Science and Pollution Research Volume: 29 Pages: 6622～6632
  • DOI: 10.1007/s11356-021-16098-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of Dispersion of Lead-Bearing Mine Wastes in Kabwe District, Zambia (2021)
  • Author(s): Nakamura Shinsaku、Igarashi Toshifumi、Uchida Yoshitaka、Ito Mayumi、Hirose Kazuyo、Sato Tsutomu、Mufalo Walubita、Chirwa Meki、Nyambe Imasiku、Nakata Hokuto、Nakayama Shouta、Ishizuka Mayumi
  • Journal Title: Minerals Volume: 11 Pages: 901～901
  • DOI: 10.3390/min11080901
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lead concentrations and isotope ratios in blood, breastmilk and feces: contribution of both lactation and soil/dust exposure to infants in a lead mining area, Kabwe, Zambia (2021)
  • Author(s): Toyomaki Haruya、Yabe John、Nakayama Shouta M.M.、Yohannes Yared B.、Muzandu Kaampwe、Mufune Tiza、Nakata Hokuto、Ikenaka Yoshinori、Kuritani Takeshi、Nakagawa Mitsuhiro、Choongo Kennedy、Ishizuka Mayumi
  • Journal Title: Environmental Pollution Volume: 286 Pages: 117456～117456
  • DOI: 10.1016/j.envpol.2021.117456
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-wide DNA methylation analysis of dogs with high lead exposure living near a lead mining area in Kabwe, Zambia (2021)
  • Author(s): Yamazaki Jumpei、Toyomaki Haruya、Nakayama Shouta M.M.、Yabe John、Muzandu Kaampwe、Jelinek Jaroslav、Yokoyama Shoko、Ikenaka Yoshinori、Takiguchi Mitsuyoshi、Ishizuka Mayumi
  • Journal Title: Environmental Pollution Volume: 286 Pages: 117229～117229
  • DOI: 10.1016/j.envpol.2021.117229
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The impact of elevated blood lead levels in children on maternal health-related quality of life (2021)
  • Author(s): Nakata Hokuto、Tohyama Harukazu、Fujita Wakako、Nakayama Shouta M.M.、Ishizuka Mayumi、Yabe John、Munyinda Nosiku S.、Sakala Doreen、Choongo Kennedy、Yamasaki Shojiro、Nagai Natsumi、Yoshida Takahiko、Saito Takeshi
  • Journal Title: Chemosphere Volume: 279 Pages: 130490～130490
  • DOI: 10.1016/j.chemosphere.2021.130490
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of lead distribution in avian organs by LA-ICP-MS: Study of experimentally lead-exposed ducks and kites (2021)
  • Author(s): Torimoto Ryouta、Ishii Chihiro、Sato Hiroshi、Saito Keisuke、Watanabe Yukiko、Ogasawara Kohei、Kubota Ayano、Matsukawa Takehisa、Yokoyama Kazuhito、Kobayashi Atsushi、Kimura Takashi、Nakayama Shouta M.M.、Ikenaka Yoshinori、Ishizuka Mayumi
  • Journal Title: Environmental Pollution Volume: 283 Pages: 117086～117086
  • DOI: 10.1016/j.envpol.2021.117086
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of LeadCare II analysis for testing of a wide range of blood lead levels in comparison with ICP-MS analysis (2021)
  • Author(s): Nakata Hokuto、Nakayama Shouta M.M.、Yabe John、Muzandu Kaampwe、Toyomaki Haruya、Yohannes Yared Beyene、Kataba Andrew、Zyambo Golden、Ikenaka Yoshinori、Choongo Kennedy、Ishizuka Mayumi
  • Journal Title: Chemosphere Volume: 271 Pages: 129832～129832
  • DOI: 10.1016/j.chemosphere.2021.129832
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS (2021)
  • Author(s): Kataba Andrew、Nakayama Shouta M. M.、Nakata Hokuto、Toyomaki Haruya、Yohannes Yared B.、Yabe John、Muzandu Kaampwe、Zyambo Golden、Kubota Ayano、Matsukawa Takehisa、Yokoyama Kazuhito、Ikenaka Yoshinori、Ishizuka Mayumi
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 18 Pages: 767～767
  • DOI: 10.3390/ijerph18020767
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of the ameliorative effect of Spirulina (Arthrospira platensis) supplementation on parameters relating to lead poisoning and obesity in C57BL/6J mice (2021)
  • Author(s): Nakata Hokuto、Nakayama Shouta M.M.、Kataba Andrew、Yohannes Yared Beyene、Ikenaka Yoshinori、Ishizuka Mayumi
  • Journal Title: Journal of Functional Foods Volume: 77 Pages: 104344～104344
  • DOI: 10.1016/j.jff.2020.104344
  • Peer Reviewed / Open Access
• [Journal Article] Delta-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes polymorphisms in children residing in an abandoned lead/zinc mine area in Kabwe, Zambia (2021)
  • Author(s): Yohannes Yared B.、Nakayama Shouta M.M.、Yabe John、Toyomaki Haruya、Kataba Andrew、Nakata Hokuto、Muzandu Kaampwe、Ikenaka Yoshinori、Choongo Kennedy、Ishizuka Mayumi
  • Journal Title: Meta Gene Volume: 27 Pages: 100838～100838
  • DOI: 10.1016/j.mgene.2020.100838
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Land Use in Habitats Affects Metal Concentrations in Wild Lizards Around a Former Lead Mining Site (2021)
  • Author(s): Nakayama SMM, Doya R, Nakata H, Toyomaki H, Yabe J, Muzandu K, Yohannes Y, Kataba A, Zyambo G, Ogawa T, Uchida Y, Ikenaka Y, Ishizuka M
  • Organizer: SETAC Europe 31st Annual Meeting
  • Int'l Joint Research
• [Presentation] Investigation of major sources of human exposure and estimation of exposure reduction effects by environmental remediation using IEUBK model in lead-contaminated area (2021)
  • Author(s): Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Kaampwe Muzandu, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 第29回環境化学討論会
• [Presentation] Evaluation of the mitigative effect of Spirulina (Arthrospira platensis) supplementation on lead poisoning and obesity in C57BL/6J mice (2021)
  • Author(s): Hokuto Nakata, Shouta M.M. Nakayama, Andrew Kataba, Yared B. Yohannes, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 第29回環境化学討論会
• [Presentation] Investigation of human exposure sources and estimation of exposure reduction effects by environmental remediation using IEUBK model in lead-contaminated area (2021)
  • Author(s): Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Kaampwe Muzandu, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 9th Zambia Water Forum and Exhibition
  • Int'l Joint Research
• [Presentation] Evaluation of the ameliorative effect of Spirulina (Arthrospira platensis) supplementation on lead poisoning and obesity in C57BL/6J mice (2021)
  • Author(s): Hokuto Nakata, Shouta M.M. Nakayama, Andrew Kataba, Yared Beyene Yohannes, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 日本アフリカ学会北海道支部オンラインレクチャー
• [Presentation] (Epi) Genetic Effects of δ-Aminolevulinic Acid Dehydratase (ALAD) in Children Exposed to Environmental Lead - a primary study from Kabwe, Zambia (2021)
  • Author(s): Yared Beyene Yohannes, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Haruya Toyomaki, Andrew Kataba, Kaampwe Muzandu, Kennedy Choongo, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 48th Annual meeting of Japanese Society of Toxicology
• [Presentation] xenobiotics 代謝と解毒の動物種差 (2021)
  • Author(s): 石塚 真由美 , 中山 翔太 , 池中 良徳
  • Organizer: 48th Annual meeting of Japanese Society of Toxicology
  • Invited
• [Presentation] 鉛中毒マウスの短期作業記憶低下および血中ステロイドの分析 (2021)
  • Author(s): 村上昂暉，中山翔太，一瀬貴大，中田北斗，Yared B. Yohannes，Andrew Kataba，平井杏梨，池中良徳，石塚真由美
  • Organizer: 第164回 日本獣医学会学術集会 日本比較薬理学・毒性学会
• [Presentation] 近年の野生鳥類における鉛中毒 (2021)
  • Author(s): 小笠原浩平、渡辺有希子、安達光、河野晴子、中山翔太、石井千尋、池中良徳、大沼学、石塚真由美、齊藤慶輔
  • Organizer: 第23回環境ホルモン学会研究発表会
• [Presentation] Isotopic Evaluation of the Contribution of Dust from a Mining Site to Heavy Metal Exposure to Wild Lizards (2021)
  • Author(s): Doya Rio, Nakayama M.M. Shouta, Nakata Hokuto, Toyomaki Haruya, Yabe John, Muzandu Kaampwe, Yohannes B. Yared, Kataba Andrew, Kuritani Takeshi, Nakagawa Mitsuhiro, Uchida Yoshitaka, Ikenaka Yoshinori, Ishizuka Mayumi,
  • Organizer: The 9th SaSSOH, 2021
  • Int'l Joint Research
• [Presentation] Accumulation of toxic and trace metals in organs of stray dogs from Kabwe in Zambia (2021)
  • Author(s): Nyein Chan Soe, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Yared B. Yohannes, Kenneth Chawinga, Golden Zyambo, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: The 9th SaSSOH, 2021
  • Int'l Joint Research
• [Presentation] Eco-Toxicological Investigation into Lead Exposure to Wild Lizards via Respiratory System (2021)
  • Author(s): Rio Doya, Shouta M.M. Nakayama, Hokuto Nakata, Haruya Toyomaki, John Yabe, Kaampwe Muzandu, Yared B. Yohannes, Andrew Kataba, Yoshitaka Uchida, Yoshinori Ikenaka, and Mayumi Ishizuka
  • Organizer: The 14th Asian Society of Conservation Medicine
  • Int'l Joint Research
• [Presentation] Wild birds lead poisoning in Honshu area (2021)
  • Author(s): Kohei Ogasawara, Hikaru Adachi, Haruko Kono, Shouta M.M. Nakayama, Naoki Tomita, Chihiro Ishii, Yoshinori Ikenaka, Yasuko Iwami, Yukiko Watanabe, Manabu Onuma, Mayumi Ishizuka, Keisuke Saito
  • Organizer: The 14th Asian Society of Conservation Medicine
  • Int'l Joint Research
• [Presentation] Lead poisoning situation in large raptors in Japan (2021)
  • Author(s): Keisuke Saito, Yukiko Watanabe, Kohei Ogasawara, Chihiro Ishii, Shouta MM Nakayama, Yoshinori Ikenaka, Hikaru Adachi, Haruko Kono, Mayumi Ishizuka
  • Organizer: The 14th Asian Society of Conservation Medicine
  • Int'l Joint Research
• [Presentation] Investigation of Human Exposure Sources and Estimation of Exposure Reduction Effects by Environmental Remediation Using IEUBK Model in Lead-contaminated Area (2021)
  • Author(s): Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Kaampwe Muzandu, Kennedy Choongo, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: SETAC North America 42nd Annual Meeting
  • Int'l Joint Research
• [Presentation] 薬物 /異物代謝と毒性の種差 Species differences in drug metabolism and toxicity (2021)
  • Author(s): 石塚真由美、池中良徳、中山翔太
  • Organizer: 日本薬物動態学会 第36回年会
  • Invited
• [Presentation] Genetic Polymorphism and Promoter Methylation of δ-Aminolevulinic Acid Dehydratase (δ-ALAD) in Children from Kabwe, Zambia (2021)
  • Author(s): Yared Beyene Yohannes, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Haruya Toyomaki, Andrew Kataba, Kaampwe Muzandu, Kennedy Choongo, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 5th International Chemical Hazard Symposium
  • Int'l Joint Research
• [Presentation] The Impact of lead poisoning in Kabwe; a holistic approach and potential mitigation measures (2021)
  • Author(s): Yabe J, Nakayama S, Nakata H, Yohannes YB, Toyomaki H, Muzandu K, Moonga G, Kataba A, Zyambo G, Munyinda NS, Mufune T, Liazambi A, Choongo K, Ikenaka Y, Ishizuka M
  • Organizer: International Symposium on Mine Impact on One Health
  • Int'l Joint Research
• [Presentation] Toxicity assessment of lead in Kabwe residents and its effect of maternal quality of life (2021)
  • Author(s): Nakata H, Nakayama S, Yabe J, Kaampwe M, Tohyama H, Fujita W, Kataba A, Yohannes YB, Toyomaki H, Zyambo G, Munyinda N, Sakala D, Yamsaki S, Nagai N, Yoshida T, Saito T, Choongo K, Ikenaka Y, Ishizuka M
  • Organizer: International Symposium on Mine Impact on One Health
  • Int'l Joint Research
• [Presentation] EVALAUTION OF LEAD EXPOSURE IN COW MILK FOR RISK ASSESSMENT IN KABWE, ZAMBIA (2021)
  • Author(s): Golden Zyambo, John Yabe, Kaampwe Muzandu, Ethel M’kandawire, Kennedy Choongo, Andrew Kataba, Kenneth Chawinga, Allan Liazambi, Shouta M. M. Nakayama, Hokuto Nakata, Mayumi Ishizuka
  • Organizer: International Symposium on Mine Impact on One Health
  • Int'l Joint Research
• [Presentation] Lead Exposure and its Epi- (Genetic) Effects on Children in Kabwe, Zambia (2021)
  • Author(s): Yared Beyene Yohannes, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Haruya Toyomaki, Andrew Kataba, Kaampwe Muzandu, Kennedy Choongo, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: International Symposium on Mine Impact on One Health
  • Int'l Joint Research
• [Presentation] Determination of heavy metals and trace elements in organs of stray dogs from Kabwe, Zambia (2021)
  • Author(s): Nyein Chan Soe, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Yared B. Yohannes, Kenneth Chawinga, Golden Zyambo, Kaampwe Muzandu, Andrew Kataba, Patricia Bwalya, Geoffrey Mainda, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: International Symposium on Mine Impact on One Health
  • Int'l Joint Research
• [Presentation] Effects of environmentally relevant lead (Pb) levels on the locomotor behaviour and molecular subcellular responses in juvenile zebrafish (Danio rerio) (2021)
  • Author(s): Andrew KATABA, Tarryn L. BOTHA, Shouta M.M. NAKAYAMA, Yared B. YOHANNES, Yoshinori IKENAKA, Victor WEPENER, Mayumi ISHIZUKA
  • Organizer: International Symposium on Mine Impact on One Health
  • Int'l Joint Research
• [Presentation] How land use patterns affect animal exposure to Pb in Kabwe? (2021)
  • Author(s): Rio Doya, Shouta M.M. Nakayama, Hokuto Nakata, Haruya Toyomaki, John Yabe, Kaampwe Muzandu, Yared B. Yohannes, Andrew Kataba, Yoshitaka Uchida, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: International Symposium on Mine Impact on One Health
  • Int'l Joint Research
• [Presentation] Efficeint recovery of Pb and Zn from zinc plant leach residues as means of detoxification (2021)
  • Author(s): Marthias Silwamba, Carlito Baltazar Tabelin, Ryota Hashizume, Tomoki Fukushima, Ilhwan Park, Sanghee Jeon, Mayumi Ito, Naoki Hiroyoshi
  • Organizer: International Symposium on Mine Impact on One Health
  • Int'l Joint Research
• [Presentation] Outline of the pilot-scale experiments at the University of Zambia (2021)
  • Author(s): Mufalo, W., Tangviroon, P., Igarashi, T., Ito, M., Sato, T., Chirwa, M., Nyambe, I., Nakata, H., Nakayama, S., Ishizuka, M
  • Organizer: International Symposium on Mine Impact on One Health
  • Int'l Joint Research
• [Presentation] Bio-accessibility of potentially toxic elements from Kabwe mine wastes (2021)
  • Author(s): Mufalo, W., Tangviroon, P., Igarashi, T., Ito, M., Sato, T., Chirwa, M., Nyambe, I., Nakata, H., Nakayama, S., Ishizuka, M
  • Organizer: International Symposium on Mine Impact on One Health
  • Int'l Joint Research
• [Presentation] Lead-bearing soil dispersion simulations in the Kabwe mine, Zambia (2021)
  • Author(s): Shinsaku Nakamura, Toshifumi Igarashi, Yoshitaka Uchida, Mayumi Ito, Kazuyo Hirose, Tsutomu Sato, Walubita Mufalo, Meki Chirwa, Imasiku Nyambe, Hokuto Nakata, Shouta Nakayama, Mayumi Ishizuka
  • Organizer: International Symposium on Mine Impact on One Health
  • Int'l Joint Research
• [Presentation] ザンビア共和国における鉛汚染問題解決に向けて～多分野融合アプローチによる実践～ (2021)
  • Author(s): 中山翔太
  • Organizer: 令和3年度育志賞研究発表会
• [Presentation] 野生鳥類における鉛中毒問題とその解決に向けて (2021)
  • Author(s): 中山翔太、石井千尋、佐藤裕、一瀬貴大、齊藤慶輔、渡邊有希子、小笠原浩平、安達光、河野晴子、鳥本亮太、小林篤史、木村享史、松川岳久、久保田章乃、横山和仁、池中良徳、石塚真由美
  • Organizer: 日本法獣医学会 第1回学術集会
• [Presentation] 北海道大学 One Health research Center の紹介と中毒診断 (2021)
  • Author(s): 池中良徳、一瀬貴大、中山翔太、石塚真由美
  • Organizer: 日本法獣医学会 第1回学術集会
• [Presentation] Lead concentrations and isotope ratios in blood, breastmilk and feces: contribution of both lactation and soil/dust exposure to infants in a lead mining area, Kabwe, Zambia (2021)
  • Author(s): Shouta M.M. Nakayama, Haruya Toyomaki, John Yabe, Yared Beyene Yohannes, Kaampwe Muzandu, Tiza Mufune, Hokuto Nakata, Yoshinori Ikenaka, Takeshi Kuritani, Mitsuhiro Nakagawa, Kennedy Choongo, Mayumi Ishizuka
  • Organizer: SOT2022
  • Int'l Joint Research
• [Remarks] 北海道大学大学院獣医学研究院毒性学教室
  • URL: http://tox.vetmed.hokudai.ac.jp/
• [Funded Workshop] International Symposium on Mine Impact on One Health (2022)