DDS treatment strategy by elucidation and control of Nano Eruption

2020 Fiscal Year Final Research Report

• Project/Area Number: 17KT0048
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Multi-year Fund
• Section: 特設分野
• Research Field: Complex Systems Disease Theory
• Research Institution: The University of Tokyo
• Principal Investigator: Matsumoto Yu 東京大学, 医学部附属病院, 講師 (80548553)
• Project Period (FY): 2017-07-18 – 2021-03-31
• Keywords: 生体イメージング / ナノテクノロジー

Outline of Final Research Achievements

We have recently discovered that the extravasation and permeation of polymeric micelles occur in a dynamic manner characterized by vascular bursts followed by a brief and vigorous outward flow of fluid (called "nano-eruptions"). By using compounds that affect the intratumoral environment, i.e. a TGF-beta inhibitor and chloroquine, the possibility of manipulating nano-eruptions to improve delivery efficiency was investigated. The results indicate that TGF-beta inhibition and chloroquine refashion the intratumoral distribution of DDSs by different mechanisms.

Free Research Field

生体イメージング

Academic Significance and Societal Importance of the Research Achievements

Nano eruptionを促進あるいは抑制する薬剤を組み合わせることにより、新しいDDS治療戦略の構築が可能となる。