2010 Fiscal Year Final Research Report
Studies on the mechanism of neural and behavioral sex determination by the Drosophila fruitless gene
| Project/Area Number |
18002012
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| Research Category |
Grant-in-Aid for Specially Promoted Research
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tohoku University |
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Principal Investigator |
YAMAMOTO Daisuke 東北大学, 大学院・生命科学研究科, 教授 (50318812)
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| Co-Investigator(Kenkyū-buntansha) |
KOGANEZAWA Masayuki 東北大学, 大学院・生命科学研究科, 准教授 (10302085)
KIMURA Kenichi 北海道教育大学, 教育学部, 教授 (80214873)
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| Project Period (FY) |
2006 – 2010
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| Keywords | 性行動 / 性分化 / 性転換 / ニューロン発生 / Drosophila / 司令ニューロン / 行動中枢 / ニューロン活動 |
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| Research Abstract |
The fruitless (fru) gene, a neural sex determinant of Drosophila, has been proposed as the master control gene for male courtship behavior. In this study, we describe the exhaustive identification of fru-expressing neurons in the brain, leading to the discovery of male-specific PI neuronal cluster that makes the decision to court and P2b neurons that convey the decision to the motor center in the thoracic ganglia. We also identified some of the factors that collaborate with Fru in establishing the single neuron sexual dimorphism.
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