2009 Fiscal Year Final Research Report
Flexible dynamics and reactions in biomolecules
| Project/Area Number |
18066005
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
SASAI Masaki Nagoya University, 大学院・工学研究科, 教授 (30178628)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 生物物理 / 化学物理 / 自己組織化 / 生体分子 / 蛋白質 |
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| Research Abstract |
Flexible dynamics of the large scale conformational change of proteins is essential in many biochemical reactions. In order to solve the principles of flexible dynamics and to bridge between quantum chemical understanding of reactions and the observed physiological phenomena, we studied the energy landscape models of protein conformation change. Also important is the flexible stochastic kinetics of reactions among biomolecules which are confined in a meso-scopic i.e. cellular size space. We studied the stochastic processes in such meso-scopic systems by developing models of biochemical reactions.
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