2010 Fiscal Year Final Research Report
Sequence Complementarity -Independence Functional RNAs
| Project/Area Number |
18107005
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKAMURA Yoshikazu The University of Tokyo, 医科学研究所, 教授 (40114590)
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| Project Period (FY) |
2006 – 2010
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| Keywords | 核酸の構造 / ノンコーディングRNA / アプタマー / 分子擬態 |
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| Research Abstract |
Functional RNAs are classified into two types : one, like antisense and microRNA, those function with the sequence complementarity to the target mRNA or DNA, while the other, like aptamer, those function independent of the sequence complementarity. In this study, we clarified superior potential of the latter class RNA that exhibits conformational plasticity by : 1) creating artificial aptamers to target proteins of therapeutic interest ; and 2)uncover the natural aptamers encoded in human genome.
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[Journal Article] Antagonistic RNA aptamer specific to a heterodimeric form of human interleukin-17A/F.2011
Author(s)
Adachi, H., Ishiguro, A., Hamada, M., Sakota, E., Asai, K., Nakamura, Y.
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Journal Title
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[Journal Article] [PSI^+] aggregate enlargement in rnq1 non-prion domain mutants, leading to a loss-of-prion in yeast.2011
Author(s)
Kurahashi, H., Pack, C., Shibata, S., Oishi, K., Sako, Y., Nakamura, Y.
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Journal Title
Genes Cells 16
Pages: 576-589
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[Journal Article] Conformational plasticity of RNA for target recognition as revealed by the 2.15A crystal structure of a human IgG-aptamer complex.2010
Author(s)
Nomura, Y., Sugiyama, S., Sakamoto, T., Miyakawa, S., Adachi, H., Takano, K., Murakami, S., Inoue, T., Mori, Y., Nakamura, Y., Matsumura, H. (co-correspondence)
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Journal Title
Nucl.Acids Res. 38
Pages: 7822-7829
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[Journal Article] Structural insights into eRF3 and stop codon recognition by eRF1.2009
Author(s)
Cheng, Z., Saito, K., Pisarev, A.V., Wada, M., Pisareva, V.P., Pestova, T.V.. Gajda, M., Round, A., Kong, C., Lim, M., Nakamura, Y., Svergun, D.I., Ito, K., Song, H.
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Journal Title
Genes Dev. 23
Pages: 1106-1118
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[Journal Article] Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population.2008
Author(s)
Wang, J., Takeuchi, H., Jin S., Sonobe Y., Shijie, J., Mizuno, T., Miyakawa, S., Fujiwara, M., Nakamura, Y., Kato, T., Muramatsu, H., Muramatsu, T., Suzumura, A.
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Journal Title
Proc.Natl.Acad.Sci.USA 105
Pages: 3915-3920
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[Journal Article] Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G.2008
Author(s)
Miyakawa, S., Nomura, Y., Sakamoto, T., Yamaguchi, Y., Kato, K., Yamazaki, S., Nakamura, Y.
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Journal Title
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[Journal Article] Crystallization and preliminary X-ray diffraction studies of an RNA aptamer in complex with the human IgG Fc fragment2008
Author(s)
Sugiyama, S., Nomura, Y., Sakamoto, T., Kitatani, T., Kobayashi, A., Miyakawa, S., Takahashi, Y., Adachi, H., Takano, K., Murakami, S., Inoue, T., Mori, Y., Nakamura, Y., Matsumura, H.
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Journal Title
Acta Crystallographica F64
Pages: 942-944
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[Journal Article] Translation termination, the prion [PSI^+], and ribosome recycling.2007
Author(s)
Ehrenberg, M., Hauryliuk V., Crist C.G., Nakamura, Y.
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Journal Title
Translational Control in Biology and Medicine.(Sonenberg N, Hershey JWB, Mathews MB, eds.)(Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press)
Pages: 173-196
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[Journal Article] RNA aptamers to mammalian initiation factor 4G inhibit cap-dependent translation by blocking the formation of initiation factor complexes.2006
Author(s)
Miyakawa, S., Oguro, A., Ohtsu, T., Imataka, H., Sonenberg, N., Nakamura, Y.
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Journal Title
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