Elucidation of molecular mechanisms of mental health improvement following a physical exercise and assembly of research resources

2009 Fiscal Year Final Research Report

• Project/Area Number: 18200041
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: National Institute of Fitness and Sports in Kanoya
• Principal Investigator: SHIBAYAMA Hidetaro National Institute of Fitness and Sports in Kanoya, 名誉教授 (00162644)
• Co-Investigator(Kenkyū-buntansha): TAKEKURA Hiroaki 鹿屋体育大学, 体育学部, 教授 (00206963) ; TAMAKI Hiroyuki 鹿屋体育大学, 体育学部, 准教授 (40253926) ; MIYACHI Motohiko 国立栄養・健康研究所, 運動ガイドラインプロジェクト, プロジェクトリーダー (60229870) ; MACHIDA Syuichi 東海大学, 体育学部, 准教授 (40421226) ; FUJIMOTO Toshihiko 東北大学, 高等教育開発推進センター, 講師 (00229048) ; SAKO Takayuki 日本女子大学, 家政学部, 講師 (20339477)
• Project Period (FY): 2006 – 2009
• Keywords: スポーツ生理学 / メンタルヘルス / 運動処方 / 自律神経機能

Research Abstract

We investigated the elucidation of molecular and cellular mechanisms of the improvement effect of mental health following a physical exercise using experimental animal models and humans ; and we applied all these fundamental research resources to develop a specific exercise prescription program for mental health improvement. Long-term physical exercise training and transient exercise change the structural and functional profiles of nerve cells at motor cortex, and may cause the mental health improvement as a consequence.

Research Products

• [Journal Article] Effects of nonexhaustive bouts of high-intensity intermittent swimming training on GLUT-4 expression in rat skeletal muscle. (2010)
  • Author(s): Fujimoto, E., Machida, S., Higuchi, M., Tabata I.
  • Journal Title: J. Physiol. Sci. 60 Pages: 95-101
  • Peer Reviewed
• [Journal Article] Effects of aerobic exercise training on brain structure and psychological well-being in young adults. (2009)
  • Author(s): Gondoh, H., Sensui, H., Kinomura, S., Fukuda, H., Fujimoto, T., Masud, M., Nagamatsu, T., Tamaki, H., Takekura, H.
  • Journal Title: J. Sports Med. Phys. Fitn. 49 Pages: 129-135
  • Peer Reviewed
• [Journal Article] Evaluation of individual skeletal muscle activity by glucose uptake during pedaling exercise at different workloads using positron emission tomography. (2009)
  • Author(s): Gondoh, Y., Tashiro, M., Itoh, M., Masud, M.M., Sensui, H., Watanuki, S., Ishi, K., Takekura, H., Nagatomi, R., Fujimoto, T.
  • Journal Title: J. Appl. Physiol. 107 Pages: 599-604
  • Peer Reviewed
• [Journal Article] Pulse wave velocity for assessment of arterial stiffness among people with spinal cord injury: a pilot study. (2009)
  • Author(s): Miyatani, M., Masani, K., Oh, P.I., Miyachi, M., Popovic, M.R., Craven, B.C.
  • Journal Title: J. Spinal Cord. Med. 32 Pages: 72-78
  • Peer Reviewed
• [Journal Article] Poor trunk flexibility is associated with arterial stiffening. (2009)
  • Author(s): Yamamoto, K., Kawano, H., Gando, Y., Iemitsu, M., Murakami, H., Sanada, K., Tanimoto, M., Ohmori, Y., Higuchi, M., Tabata, I., Miyachi, M.
  • Journal Title: Am. J. Physiol., Heart Circ Physiol. 297 Pages: 1314-1318
  • Peer Reviewed
• [Journal Article] Resistance training in men is associated with increased arterial stiffness and blood pressure but does not adversely affect endothelial function as measured by arterial reactivity to the cold pressor test. (2008)
  • Author(s): Kawano, H., Tanimoto, M., Yamamoto, K., Sanada, K., Gando, Y., Tabata, I., Higuchi, M., Miyachi, M.
  • Journal Title: Exp. Physiol. 93 Pages: 296-302
  • Peer Reviewed
• [Journal Article] 筋活動様式の違いが翌日の静的仕事に及ぼす影響. (2006)
  • Author(s): 田巻弘之, 北田耕司, 桐本光, 與谷謙吾, 荻田太, 竹倉宏明, 芝山秀太郎
  • Journal Title: 生理人類学雑誌 11 Pages: 19-24
  • Peer Reviewed
• [Journal Article] Bidirect signaling between calcium channels of skeletal muscle requires multiple direct and indirect interactions. (2006)
  • Author(s): Sheridan, D.C., Takekura, H., Franzini-Armstrong, C., Beam, K.G., Allen, P.D., Perez, C.F.
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 19760-19765
  • Peer Reviewed
• [Journal Article] Resistance training and arterial compliance: keeping the benefits while minimizing the stiffening. (2006)
  • Author(s): Kawano, H., Tanaka, H., Miyachi, M.
  • Journal Title: J. Hyperten. 24 Pages: 1753-1759
  • Peer Reviewed
• [Journal Article] Fluctuations in carotid arterial distensibility during the menstrual cycle do not influence cardiovagal baroreflex sensitivity. (2006)
  • Author(s): Hayashi, K., Miyachi, M., Seno, N., Takahashi, K., Yamazaki, K., Sugawara, J., Yokoi, T., Onodera, S., Mesaki, N.
  • Journal Title: Acta Physiol 86 Pages: 103-110
  • Peer Reviewed
• [Presentation] 短時間低強度運動が計算作業量および脳血流動態に及ぼす影響. (2009)
  • Author(s): 佐古隆之, 竹倉宏明
  • Organizer: 体力科学
  • Year and Date: 20090000
• [Presentation] 経頭蓋磁気刺激を用いた視覚-運動関連時間の同定と反応トレーニングの効果. (2009)
  • Author(s): 與谷謙吾, 坂下一平, 行方功史, 河原一仁, 幸篤武, 北田耕司, 桐本光, 田巻弘之, 荻田太, 竹倉宏明
  • Organizer: 体力科学
  • Year and Date: 20090000
• [Presentation] 若年者における有酸素能力と脳構造の関係 (2008)
  • Author(s): 権藤雄一, 泉水宏臣, 藤本敏彦, 永松俊哉, 竹倉宏明
  • Organizer: 体力科学
  • Year and Date: 20080000
• [Presentation] 計算課題中の前頭葉前額部血流動態に及ぼす短時間低強度運動の影響. (2008)
  • Author(s): 佐古隆之, 竹倉宏明, 芝山秀太郎
  • Organizer: 体力科学
  • Year and Date: 20080000
• [Presentation] PETを用いた高強度運動後の脳内セロトニン神経活動の観察. (2007)
  • Author(s): 藤本敏彦, 永松俊哉, 泉水弘臣, 菊地次郎, 小川静香, 石井賢治, 千葉登, 永富良一, 権藤雄一, 竹倉宏明
  • Organizer: 体力科学56
  • Year and Date: 20070000
• [Presentation] 有酸素トレーニングによる脳構造と精神的健康度への影響. (2007)
  • Author(s): 権藤雄一, 泉水弘臣, 藤本敏彦, 永松俊哉, 竹倉宏明
  • Organizer: 体力科学
  • Year and Date: 20070000
• [Presentation] Poor flexibility is associated with arterial stiffening. (2007)
  • Author(s): Yamamoto, K., Kawano, H., Gando, Y., Sanada, K., Tanimoto, M., Oh, T., Ohmori, Y., Higuchi, M., Tabata, I., Miyachi, M.
  • Organizer: 54th ACSM
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 20070000
• [Presentation] Greater age-related arterial stiffening and left ventricular hypertrophy in poor cardiorespiratory fitness women. (2007)
  • Author(s): Gando, Y., Miyachi, M., Kawano, H., Sanada, K., Yamamoto, K., Tanimoto, M., Oh, T., Ohmori, Y., Miyatani, M., Usui., C., Takahashi, E., Tabata, I., Higuchi, M.
  • Organizer: 54th ACSM
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 20070000
• [Presentation] Regeneration of aging skeletal muscle is associated with impaired inflammation and increased adipogenesis (2007)
  • Author(s): Machida, S.
  • Organizer: 12th ECSS, JSPFSM Exchange Symposium
  • Place of Presentation: Jyvaskyla, Finland
  • Year and Date: 20070000
• [Presentation] The relation between hippocampal structure and psychological well-being in exercising and non-exercising students. (2006)
  • Author(s): Fujimoto, T., Sensui, H., Takekura, H., Gondo, Y., Ono, Y., Ogawa, S., Kikuchi, J., Kinomura, S., Tashiro, M., Itoh, M., Nagamatsu, T., Nagatomi, R.
  • Organizer: 11th ECSS
  • Place of Presentation: Lausanne, Switzerland
  • Year and Date: 20060000
• [Book] 筋細胞内情報伝達機構. 宮村実晴編集, 身体トレーニング (2009)
  • Author(s): 竹倉宏明, 秋元良太
  • Publisher: 真興交易医書出版部
• [Book] サルコペニアモデル動物の評価, 老化・老年病研究のための動物実験ガイドブック. (2008)
  • Author(s): 町田修一
  • Total Pages: 202-210
  • Publisher: 日本基礎老化学会編
• [Book] Homeostatic control of whole-body energy metabolism by exercise: A positron emission tomography study (2007)
  • Author(s): Masud, M., Fujimoto, T., Tashiro, M., Miyake, M., Watanuki, S., Itoh, M., Esashi, M., et. al.
  • Total Pages: 761-769
  • Publisher: Future medical engineering based on bionanotechnology