2009 Fiscal Year Final Research Report
Relation between allergic characteristics and intestinal flora
| Project/Area Number |
18200044
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Hirosaki University |
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Principal Investigator |
NAKAJI Shigeyuki Hirosaki University, 大学院・医学研究科, 教授 (10192220)
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| Co-Investigator(Kenkyū-buntansha) |
梅田 孝 弘前大学, 大学院・医学研究科, 准教授 (50311535)
高橋 一平 弘前大学, 大学院・医学研究科, 助教 (70400132)
福田 真作 弘前大学, 大学院・医学研究科, 教授 (60261450)
下山 克 弘前大学, 医学部・附属病院, 講師 (50312492)
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| Co-Investigator(Renkei-kenkyūsha) |
辨野 義己 理化学研究所, 知的財産戦略センター, 特別招聘研究員 (40087599)
松崎 靖司 東京医科大学, 霞ヶ浦病院, 教授 (50209532)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 腸内細菌 / アレルギー / 疫学調査 / 地域住民 / 弘前市岩木地区 |
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| Research Abstract |
A remarkable increase in the number of allergic disease has been observed in recent years. At the same time, the role of intestinal flora and its association with the disease has been gaining attention, although its etiology has not been clarified due to the difficulties to measure and culture intestinal flora. Approximately 1014 with more than 400 types of intestinal flora are present in a human body, and 60%-80% of them have been found to be unculturable. Consequently, previously reported researches have been carried out based on the 30% of culturable intestinal flora only. Therefore, it is extremely important to understand the overall image of intestinal flora in order to clarify the associations between allergy diseases and intestinal flora.
The present study was targeted to residents at Iwaki area in Hirosaki city, Aomori prefecture in Japan to investigate the situations of allergy and intestinal flora. The association between them was analysed by using the multiple logistic regression analysis. Subjects were 747 Iwaki residents (281 males and 466 females) over 20 years old, and information on their allergic situations (presence of eczema, hay fever, alimentary allergy, respiratory allergy such as bronchial asthma, nose and eye allergy, and cutaneous allergy) as well as their intestinal flora were collected and measured (DNA profiling and ITU according to the Nagashima method). As a result, cutaneous allergy was found to be associated with some ITUs, and the significant associations were observed between nose and eye allergy and 9 ITUs which accounted for 41% of total ITUs.
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[Journal Article] The recovery rate at the human terminal ileum of an orally administered non-digestive oligosaccharide (raffinose)2009
Author(s)
Shimaya S, Shimoyama T, Fukuda S, Matsuzaka M, Takahashi I, Umeda T, Chinda D, Saito D, Sakamoto J, Nagura T, Danjo K, Nakaji S.
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Journal Title
Int J Food Sci Nutr. 60
Pages: 344-351
Peer Reviewed
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[Journal Article] Are individuals with lower neutrophil oxidative burst activity more prone to Helicobacter pylori infection?2008
Author(s)
Matsuzaka M, Fukuda S, Yamai K, Tsuya R, Fukuoka Y, Takahashi I, Yaegaki M, Shimoyama T, Sakamoto J, Umeda T, Nakaji S.
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Journal Title
Luminescence 23(3)
Pages: 132-8
Peer Reviewed
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[Presentation] No association between green tea consumption and chronic atrophic gastritis : The Iwaki health promotion study2008
Author(s)
Matsuzaka M, Danjo K, Yamai K, Tsuya R, Inoue R. Iwane S, Kurauchi S, Takahashi I, Shimoyama T, Sakamoto J, Fukuda S, Umeda T, Nakaji S.
Organizer
16th United European Gastroenterology Week
Place of Presentation
Austria Center Vienna Vienna, Austria
Year and Date
2008-10-22
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[Presentation] The relationship between irritable bowel syndrome and depression among the general population in Japan2008
Author(s)
Danjo K, Matsuzaka M, Yamai K, Iwane K, Tsuya R, Inoue R, Yano T, Kumagai T, Takahashi I, Umeda T, Nakaji S.
Organizer
16th United European Gastroenterology Week
Place of Presentation
Austria Center Vienna Vienna, Austria
Year and Date
2008-10-22
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Author(s)
Yamai K, T Umeda T Shimoyama, J Sakamoto, Fukuda S, Inoue R, Tsuya R, Iwane K, Ito H, Matsuzaka M, Takahashi I, Danjo K, Nakaji S.
Organizer
16th United European Gastroenterology Week
Place of Presentation
Austria Center Vienna Vienna, Austria
Year and Date
2008-10-22
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[Presentation] The prevalence of irritable bowel syndrome among the Japanese general population2008
Author(s)
Yamai K,. Umeda T, Inoue R, Tsuya R, Iwane K, Chisyaki T, Matsuzaka M, Takahashi I, Danjo K, Nakaji S.
Organizer
16th United European Gastroenterology Week
Place of Presentation
Austria Center Vienna Vienna, Austria
Year and Date
2008-10-22
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[Presentation] The relationship between Helicobacter pylori infection and arterial stiffness in the Japanese general population2008
Author(s)
Yamai K, Umeda T, Inoue R, Tsuya R, Iwane K, Sumikawa K, Shimoyama T, Sakamoto J, Fukuda S, Matsuzaka M, Takahashi I, Danjo K, Nakaji S.
Organizer
Helicobacter pylori : 16th United European Gastroenterology Week
Place of Presentation
Austria Center Vienna Vienna, Austria
Year and Date
2008-10-20
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[Presentation] Are individuals with lower neutrophil oxidative burst activity more prone to Helicobacter pylori infection?2008
Author(s)
Matsuzaka M, Danjo K, Yamai K, Tsuya R, Inoue R, Iwane K, Koga T, Takahashi I, Shimoyama T, Sakamoto J, Fukuda S, Umeda T, Nakaji S.
Organizer
16th United European Gastroenterology Week
Place of Presentation
Austria Center Vienna Vienna, Austria
Year and Date
2008-10-20
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[Presentation] The positive association between chronic atrophic gastritis and serum opsonic activity of peripheral blood neutrophils2008
Author(s)
Matsuzaka M, Danjo K, Yamai K, Tsuya R, Inoue R, Iwane K, Tsubakihara T, Takahashi I, Shimoyama T, Sakamoto J, Fukuda S, Umeda T, Nakaji S.
Organizer
16th United European Gastroenterology
Place of Presentation
Austria Center Vienna Vienna, Austria
Year and Date
2008-10-20
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