Development of carbon nanotube/ceramic composites as new biomaterials for artificial joint

2009 Fiscal Year Final Research Report

• Project/Area Number: 18201021
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: Shinshu University
• Principal Investigator: SAITO Naoto Shinshu University, 医学部, 教授 (80283258)
• Co-Investigator(Kenkyū-buntansha): ENDO Morinobu 信州大学, 工学部, 教授 (10021015) ; TARUTA Seiichi 信州大学, 工学部, 教授 (00217209) ; KATO Hiroyuki 信州大学, 医学部, 教授 (40204490) ; HORIUCHI Hiroshi 松代総合病院, 整形外科, 部長 (80377639) ; TENSHO Keiji 信州大学, 医学部, 助教 (20419378) ; ISHIGAKI Norio 信州大学, 医学部附属病院, 助教(診療) (20447725) ; NAKAMURA Kouichi 信州大学, 医学部附属病院, 助教(特定雇用) (80419382) ; KAWAKUBO Yoichi 信州大学, 工学部, 教授 (40313829) ; USUI Yuki 信州大学, 医学部附属病院, 助教(診療) (00467169) ; AOKI Kaoru 信州大学, 医学部附属病院, 医員 (30467170) ; SHIMIZU Masayuki 信州大学, 医学部附属病院, 医員 (40467171) ; OGIWARA Nobuhide 信州大学, 医学部附属病院, 助教(診療) (40447727) ; HARA Kazuo 信州大学, 医学部附属病院, 医員 (00532045)
• Project Period (FY): 2006 – 2009
• Keywords: 生体材料 / カーボンナノチューブ / セラミックス / 複合体 / 人工関節

Research Abstract

人工関節において現在最も改良が期待されている摺動部材のセラミックスについて、カーボンナノチューブ(CNT)を用いた新規複合体の開発を行った。高分散処理したCNTを高純度アルミナ粉末と混合し、真空焼結とHIP処理の併用やプラズマ焼結することにより複合体を作製した。CNTが均一混合した緻密な複合体が得られ、高強度、高靭性を示した。また、CNTを生体材料として用いる場合に重要な生体適合性を評価し、CNTおよびその複合体は生体親和性が高く、生体材料として有害な事象を示さなかった。

Research Products

• [Journal Article] Carbon nanotubes: biomaterial applications. (2009)
  • Author(s): Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Taruta S, Endo M.
  • Journal Title: Chem Soc Rev 38(7) Pages: 1897-1903
  • Peer Reviewed
• [Journal Article] A thin carbon fiber web as a scaffold for bone tissue regeneration. (2009)
  • Author(s): Aoki K, Usui Y, Narita N, Ogiwara N, Ishigaki N, Nakamura K, Kato H, Sano K, Ogiwara N, Kametani K, Kim C, Taruta S, Kim YA, Endo M, Saito N.
  • Journal Title: Small 5(13) Pages: 1540-1546
  • Peer Reviewed
• [Journal Article] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function. (2009)
  • Author(s): Narita N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Usui Y, Aoki K, Shimizu M, Kato H, Ozawa H, Udagawa N, Endo M, Takahashi N, Saito N.
  • Journal Title: Nano Lett 9(4) Pages: 1406-1413
  • Peer Reviewed
• [Journal Article] Carbon nanotubes for biomaterials in contact with bone. (2008)
  • Author(s): Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Taruta S, Endo M.
  • Journal Title: Curr Med Chem 15(5) Pages: 523-527
  • Peer Reviewed
• [Journal Article] Carbon nanotubes with high bone-tissue compatibility and bone-formation acceleration effect. (2008)
  • Author(s): Usui Y, Aoki K, Narita N, Murakami N, Nakamura I, Nakamura K, Ishigaki N, Yamazaki H, Horiuchi H, Kato H, Taruta S, Kim YA, Endo M, Saito N.
  • Journal Title: Small 4(2) Pages: 240-246
  • Peer Reviewed
• [Journal Article] Preparation and mechanical properties of machinable alumina/mica composites. (2006)
  • Author(s): Taruta S, Fujisawa R, Kitajima K.
  • Journal Title: J Eur Ceram Soc 26 Pages: 1687-1693
  • Peer Reviewed
• [Presentation] Carbon nanotubes: Biomaterial applications and safety. (2010)
  • Author(s): Saito N.
  • Organizer: 3rd International Workshop on CNT's Toxicology and Safety
  • Place of Presentation: Nagano, Japan, (Workshop)
  • Year and Date: 2010-02-16
• [Presentation] Carbon Nanotubes Show High Bone Tissue Compatibility. (2009)
  • Author(s): Usui Y, Aoki K, Shimizu M, Ogiwara N, Iashigaki N, Nakamura K, Kato H, Endo M, Saito N.
  • Organizer: 22nd European Conference on Biomaterials (ESB2009)
  • Place of Presentation: Lausanne, Switzerland
  • Year and Date: 20090907-20090911
• [Presentation] Mechanidal Properties and Bone Tissue Compatibility of Polyethylene / Multi-Walled Carbon Nanotube Composite. (2009)
  • Author(s): Aoki K, Hara K, Narita N, Usui Y, Shimizu M, Ogiwara N, Ishigaki N, Nakamura K, Kato H, Todoroki H, Ito I, Endo M, Saito N.
  • Organizer: 22nd European Conference on Biomaterials, (ESB2009)
  • Place of Presentation: Lausanne, Switzerland
  • Year and Date: 20090907-20090911
• [Presentation] Biocompatibility of thin carbon fiber web as a scaffold for bone regeneration. (2009)
  • Author(s): Aoki K, Usui Y, Hara K, Narita N, Shimizu M, Ogiwara N, Ishigaki N, Nakamura K, Kato H, Taruta S, Kim YA, Endo M, Saito N.
  • Organizer: 4th International Conference on Nanotechnology-Occupational and Environmental Health
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 20090826-20090829
• [Presentation] Multi-walled Carbon nanotubes show high bone tissue compatibility. (2009)
  • Author(s): Usui Y, Aoki K, Shimizu M, Ogiwara N, Ishigaki N, Nakamura K, Kato H, Endo M, Saito N.
  • Organizer: 4th International Conference on Nanotechnology-Occupational and Environmental Health
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 20090826-20090829
• [Presentation] Biocompatibility of carbon nanotubes. (2009)
  • Author(s): Aoki K, Usui Y, Endo M, Saito N.
  • Organizer: Workshop of the safety assessment of the carbon nanotubes in American National Institute for Occupational Safety and Health, and the Environmental Protection Agency
  • Place of Presentation: West Virginia, USA
  • Year and Date: 20090226-20090227
• [Presentation] Bone Tissue Compatibility of Carbon Nanotubes. (2009)
  • Author(s): Aoki K, Usui Y, Hara K, Narita N, Simizu M, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Kim YA, Taruta S, Endo M, Kobayashi Y, Saito N.
  • Organizer: 2nd International Workshop on CNT's Toxicology and Safety (IWCTS)
  • Place of Presentation: Nagano(Workshop)
  • Year and Date: 2009-06-22
• [Presentation] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function. (2008)
  • Author(s): Narita N, Usui Y, Aoki K, Simizu M, Kato H, Saito N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Ozawa H, Udagawa N, Takahashi N, Endo M.
  • Organizer: NanoEurope 2008
  • Place of Presentation: St. Gallen, Switzerland
  • Year and Date: 20080916-20080917
• [Presentation] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function. (2008)
  • Author(s): Narita N, Kobayashi Y, Nakamura H, Maeda K, Mizoguchi T, Kato H, Ozawa H, Udagawa N, Endo M, Takahashi N, Saito N.
  • Organizer: 30th the American Society for Bone and Mineral Research Annual Meeting
  • Place of Presentation: Montreal, Canada
  • Year and Date: 20080912-20080916
• [Presentation] Fabrication of carbon nano-fiber/almina composites by vacuum sintering and hot isostatic pressing. (2008)
  • Author(s): Taruta S, Yamaguchi T, Kitajima K, Usui Y, Aoki K, Endo M, Saito N.
  • Organizer: Carbon 2008
  • Place of Presentation: Nagano
  • Year and Date: 20080713-20080718
• [Presentation] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function. (2008)
  • Author(s): Narita N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Usui Y, Aoki K, Simizu M, Kato H, Ozawa H, Udagawa N, Endo M, Takahashi N, Saito N.
  • Organizer: Carbon 2008
  • Place of Presentation: Nagano
  • Year and Date: 20080713-20080718
• [Presentation] Carbon nanotubes show high bone tissue compatibility and accelerate bone formation. (2008)
  • Author(s): Usui Y, Aoki K, Narita N, Nakamura K, Ishigaki N, Kato H, Kim YA, Taruta S, Endo M, Saito N.
  • Organizer: Carbon 2008
  • Place of Presentation: Nagano
  • Year and Date: 20080713-20080718
• [Presentation] A thin carbon fiber web as a scaffold for bone tissue regeneration. (2008)
  • Author(s): Aoki K, Usui Y, Kato H, Kim YA, Endo M, Saito N.
  • Organizer: Carbon 2008
  • Place of Presentation: Nagano
  • Year and Date: 20080713-20080718
• [Presentation] Development of novel carbon fiber sheet as a scaffold for bone regeneration. (2008)
  • Author(s): Aoki K, Narita N, Shimizu M, Usui Y, Ogiwara N, Ishigaki N, Nakamura K, Kato H, Kim YA, Taruta S, Endo M, Saito N.
  • Organizer: 8th World Biomaterials Congress
  • Place of Presentation: Amsterdam
  • Year and Date: 20080528-20080601
• [Presentation] Carbon nanotube compatibility with Bone Tissue. (2008)
  • Author(s): Saito N.
  • Organizer: INNO. 08
  • Place of Presentation: Montreal
  • Year and Date: 20080421-20080423
• [Presentation] Carbon nanotubes show high bone tissue compatibility. (2007)
  • Author(s): Usui Y, Aoki K, Narita N, Murakami N, Nakamura K, Nakamura I, Ishigaki N, Yamazaki H, Horiuchi H, Kato H, Taruta S, Endo M, Saito N.
  • Organizer: 6th Combined Meeting of the Orthopaedic Reserch Societies
  • Place of Presentation: Honolulu
  • Year and Date: 20071020-20071024
• [Presentation] Development of novel carbon fiber sheet as a scaffold for bone regeneration. (2007)
  • Author(s): Aoki K, Narita N, Usui Y, Ogiwara N, Ishigaki N, Nakamura K, Murakami N, Nakamura I, Kato H, Kim YA, Taruta S, Endo M, Saito N.
  • Organizer: 6th Combined Meeting of the Orthopaedic Reserch Societies
  • Place of Presentation: Honolulu
  • Year and Date: 20071020-20071024
• [Presentation] Carbon nanotubes show high bone tissue compatibility and accelerate bone formation in vivo. (2007)
  • Author(s): Usui Y, Aoki K, Narita N, Murakami N, Nakamura I, Ishigaki N, Yamazaki H, Horiuchi H, Kato H, Taruta S, Endo M, Saito N.
  • Organizer: NSTI Nanotechnology Conference and Trade Show
  • Place of Presentation: Santas Clara
  • Year and Date: 20070520-20070524
• [Presentation] Development of novel carbon fiber sheet as a scaffold for bone regeneration. (2007)
  • Author(s): Aoki K, Narita N, Usui Y, Kato H, Kim YA, Endo M, Saito N.
  • Organizer: NSTI Nanotechnology Conference and Trade Show
  • Place of Presentation: Santas Clara
  • Year and Date: 20070520-20070524
• [Book] Thin carbon fiber web that functions as a scaffold for tissue regeneration. In: Columbus NG (ed), Tissue regeneration and repair: procedures, clinical implications and applications, Nova Science Publishers (2010)
  • Author(s): Saito N, Aoki K, Usui Y, Shimizu M, Hara K, Narita N, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Hanyiu H, Kim C, Taruta S, Kim YA, Endo M
  • Publisher: Nova Science Publishers, Inc. (in press)
• [Book] Application of carbon nanotubes on scaffolds for bone tissue regeneration. In: Legard V, Schluter R (eds), Bone regeneration: growth factors, augmentation procedures and tissue engineering applications, Nova Science Publishers (2010)
  • Author(s): Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, Endo M
  • Publisher: Nova Science Publishers, Inc. (in press)
• [Book] New technology for bone tissue regeneration using cytokines and their drug delivery systems. In: Mashkevich BO (ed), Drug delivery research advances, pp227-241, Nova Science Publishers (2007)
  • Author(s): Saito N, Murakami N, Takaoka K
  • Publisher: Nova Science Publishers, Inc. (in press)
• [Remarks] Nature Publishing Group, Asia Materials(平成21年6月29日)
  • URL: http://www.natureasia.com/asia-materials/highlight.php?id=469
• [Remarks] 信濃毎日新聞(朝刊)平成21年7月8日(1面)掲載
• [Remarks] 信濃毎日新聞(朝刊)平成20年2月21日(1面)掲載