2008 Fiscal Year Self-evaluation Report
Regulatory Mechanism of Sperm Function in Female Reproductive Tract
| Project/Area Number |
18208029
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
BABA Tadashi University of Tsukuba, 大学院・生命環境科学研究科, 教授 (40165056)
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| Project Period (FY) |
2006 – 2008
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| Keywords | 受精 / 子宮 / 輸卵管 / 精子機能 / マウス |
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| Research Abstract |
この研究では、精子が雌性生殖器内で子宮から輸卵管へ移動し卵管膨大部で卵子と融合するまでの過程で起こる仕組みを明らかにするための基礎研究を推進する。具体的には、マウス子宮や卵管での精子の受精能獲得機構や卵管膨大部での卵子卵丘細胞複合体による精子選別機構などに関する研究を行い、哺乳動物雌性生殖器での精子機能制御機構に関して総括的にまとめる。
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[Journal Article] Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is rescued by sperm exposure to uterine microenvironment2008
Author(s)
Yamashita, M., Honda, A., Ogura, A., Kashiwabara, S., Fukami, K., and Baba, T.
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Journal Title
Genes Cells 13
Pages: 1001-1013
Peer Reviewed
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[Journal Article] Sperm penetration through cumulus mass and zona pellucida2008
Author(s)
Kim, E., Yamashita, M., Kimura, M., Honda, A., Kashiwabara, S., and Baba, T.
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Journal Title
Int. J. Dev. Biol 52
Pages: 677-682
Peer Reviewed
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[Journal Article] Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization2006
Author(s)
Kim, E., Yamashita, M., Nakanishi, T., Park, K. -E., Kimura, M., Kashiwabara, S., and Baba, T.
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Journal Title
J. Biol. Chem 281
Pages: 5634-5639
Peer Reviewed
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