2009 Fiscal Year Final Research Report
Development of a diagnostic test of bipolar disorder using gene expression analysis
| Project/Area Number |
18209038
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KATO Tadafumi The Institute of Physical and Chemical Research, 精神疾患動態研究チーム, チームリーダー (30214381)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 双極性障害(躁うつ病) / 遺伝子発現 / 培養リンパ芽球 / ミトコンドリア |
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| Research Abstract |
We previously reported that neuron-specific mutant Polg1 (mitochondrial DNA polymerase) transgenic (Tg) mice exhibited bipolar disorder (BD)-like phenotypes. We searched for the genes differentially expressed between post-mortem brains of BD patients and control subjects, and between the brains of Tg and wild-type mice. Gene ontology analysis showed that 16 categories overlapped in the altered gene expression profiles of BD patients and the mouse model. In the brains of Tg mice, 33 genes showed similar changes in the frontal cortex and hippocampus compared to wild-type mice. Among the 33 genes, SFPQ and PPIF were differentially expressed in post-mortem brains of BD patients compared to control subjects. These genes and other candidate genes were used for the gene expression analysis in lymphoblastoid cells obtained from patients with bipolar disorder and control subjects. Using 17 genes, the first sample were classified into patients and controls. Using this discriminate function, the second sample set was classified. Discrimination of the second sample was close to significance (p=0.05). These findings suggest that gene expression analysis may be useful for the diagnosis of bipolar disorder.
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[Journal Article] Up-regulation of ADM and SEPX1 in the lymphoblastoid cells of patients in monozygotic twins discordant for schizophrenia.2008
Author(s)
K akiuchi C, Ishiwata M, Nanko S, Ozaki N, Iwata N, Umekage T, Tochigi M, Kohda K, Sasaki T, Imamura A, Okazaki Y, Kato T
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Journal Title
American Journal of Medical Genetics Part B(Neuropsychiatric Genetics) 147B
Pages: 557-564
Peer Reviewed
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[Journal Article] Association analysis of HSP90B1 with bipolar disorder.2007
Author(s)
K akiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Umekage T, Tochigi M, Kohda K, Sasaki T, Yamada K, Yoshikawa T, Kato T
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Journal Title
Journal of Human Genetics 52
Pages: 794-803
Peer Reviewed
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