2009 Fiscal Year Final Research Report
In vivo pretreatment of bio-derived and synthetic for cardiovascular tissue regeneration.
| Project/Area Number |
18209042
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
NAKATANI Takeshi National Cardiovascular Center Research Institute, 臓器移植部, 部長 (60155752)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAOKA Tetsuji 国立循環器病センター研究所, 生体工学部, 部長 (50243126)
FUJISATO Toshiya 国立循環器病センター研究所, 再生医療部, 室長 (60270732)
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| Project Period (FY) |
2006 – 2009
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| Keywords | スキャホールド / 脱細胞 / ポリ乳酸 / 組織移植 / 再生医工学 |
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| Research Abstract |
In pre-implantation of the synthetic biodegradable scaffolds (templates) the induced ingrowth of the surrounding tissue into the scaffolds and the suppressed hyperplasia based on the excess of tissue ingrowth cold be controlled by regulating the structure and chemical features of the nanofiber matrices for the scaffolds. In addition, in vivo acellularization of the small-diameter blood vessel based on the complement system has been found to be very effective to maintain the structure and mechanical property of the blood vessel walls.
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