• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2008 Fiscal Year Self-evaluation Report

Elcidation of Total Molecular Mechanisms Regulating Endochondral Ossification

Research Project

  • PDF
Project/Area Number 18209047
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

KAWAGUCHI Hiroshi  The University of Tokyo, 医学部附属病院, 准教授 (40282660)

Project Period (FY) 2006 – 2009
Keywords軟骨細胞 / 軟骨内骨化 / 転写因子
Research Abstract

p63 による軟骨細胞の制御機構を、以下のサブテーマに分けて研究する。
(1) 軟骨内骨化におけるp63 シグナルネットワークの解明
(1) 既知の軟骨内骨化シグナルにおけるp63 の関与の検討
(2) p63の発現調節機構の解明
(3) p63の作用調節分子および下流分子の検索
(2) 変形性関節症におけるp63シグナルの関与の検討

  • Research Products

    (8 results)

All 2009 2008 2007

All Journal Article (6 results) Presentation (2 results)

  • [Journal Article] Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells2009

    • Author(s)
      Ushita M, Ikeda T, Chung U, Kawaguchi H(その他5名)
    • Journal Title

      Osteoarthritis Cartilage, E-pub

  • [Journal Article] C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of2009

    • Author(s)
      Hirata M, Ikeda T, Chung U, Kawaguchi H(その他9名)
    • Journal Title

      PLoS ONE 4

      Pages: 57

  • [Journal Article] Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene2009

    • Author(s)
      Higashikawa A, Ikeda T, Chung U, Kawaguchi H (その他9名)
    • Journal Title

      Arthritis Rheum 60

      Pages: 166-78

  • [Journal Article] Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity2008

    • Author(s)
      Ohba S, Ikeda T, Chung U, Kawaguchi H (その他11名)
    • Journal Title

      Dev Cell 14

      Pages: 689-99

  • [Journal Article] Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes2008

    • Author(s)
      Kawasaki Y, Ikeda T, Chung U, KawaguchiH (その他14名)
    • Journal Title

      J Clin Invest 118

      Pages: 2506-15

  • [Journal Article] Identification and characterization of the human SOX_6 promoter2007

    • Author(s)
      Ikeda T, Chung U, Kawaguchi H (その他7名)
    • Journal Title

      Biochem Biophys Res Commun 357

      Pages: 383-90

  • [Presentation] p63 Plays a Central Role in Cartilage Development by Directly Regulating Key Genes for Chondrogenesis2007

    • Author(s)
      Toshiyuki Ikeda et.al
    • Organizer
      The American Society for Bone and Mineral Research 29th Annual Meeting
    • Place of Presentation
      Hawaii,USA.
    • Year and Date
      2007-09-18
  • [Presentation] p63は軟骨の初期分化から後期分化までを統合的に支配するマスター転写因子である2007

    • Author(s)
      池田敏之ら
    • Organizer
      第25回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-19

URL: 

Published: 2010-06-11   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi