2007 Fiscal Year Final Research Report Summary
Histological analysis of brain injury with two-photon microscopy
| Project/Area Number |
18300121
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Mie University |
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Principal Investigator |
MIZOGUCHI Akira Mie University, Graduate school of Medicine, Professor (90181916)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Saburo Mie University, Graduate school of Medicine, part-time lecturer (70024635)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Stroke / Thrombosis / Glia cells / Two photon microscopy / GFP Green mouse / Synapse formation / Cell Adhesion / Wiring Specificity |
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| Research Abstract |
We have succeeded in rescuing placental dysplasia caused by deletion of genes, Est2, Mapk14, and Mapkl through placenta-specific gene transfer (Nature Biotechnol). We have also demonstrated that a prototype cadherin, Arcadrin, is involved in control of dendritic spine number (Neuron). By aggregation assav, we have shown hemophilic cell adhesion activity mediated by water channel aquaporin 4.1
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