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2008 Fiscal Year Self-evaluation Report

Establishing cynomolgus monkey transplant models using tailor-made ES cells

Research Project

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Project/Area Number 18300140
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionShiga University of Medical Science

Principal Investigator

TORII Ryuzo  Shiga University of Medical Science, 動物生命科学研究センター, 教授 (50106647)

Project Period (FY) 2006 – 2009
Keywordsカニクイザル / 体細胞核移植 / テーラーメードES細胞
Research Abstract

本研究の目的は、ヒトと同じ霊長類に属するカニクイザルを用いて、テーラーメードES細胞を樹立しそれを用いた細胞移植医療モデルシステムの構築によって細胞移植医療の有効性、安全性を正確に評価、検証することにあり、これはまた ES細胞を用いる再生医療が実現可能なものとなることが出来るか否かをも決定づける極めて重要な位置にある。即ち、これからの老齢化社会において深刻な問題となるヒトの細胞移植医療、再生医療の有効性および安全性を事前に詳細に検証することにもつながる。しかしながら、世界で初めて報告された韓国のヒトのテーラーメードES細胞樹立の報告が捏造であったことが判明し、体細胞核移植技術の難しさが改めて指摘されたことから、本研究も慎重に検討を進めている。

  • Research Products

    (21 results)

All 2009 2008 2007 2006

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (15 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A cynomolgus monkey embryonic stem cell line derived from a single blastomere2008

    • Author(s)
      Okahara-Narita J, Yamasaki J, Iwatani C, Tsuchiya H, Torii R
    • Journal Title

      Fertility and Development 20(1)

      Pages: 224-225

    • Peer Reviewed
  • [Journal Article] Success in deliveries of clonal offspring derived from separated blastomeres in cynomolgus monkey (Macaca fascicularis)2008

    • Author(s)
      Iwatani C, Okahara-Narita J, Yamasaki J, Tsuchiya H, Torii R
    • Journal Title

      Exp. Anim 57

      Pages: 3,273

    • Peer Reviewed
  • [Journal Article] Laparoscopic evaluation of ovarian reaction to hormone stimulation in cynomolgus monkeys (Macaca fascicularis)2007

    • Author(s)
      Tsuchiya H, Iwatani C, Yamasaki J, Okahara JN, Okahara N, Torii R
    • Journal Title

      Reproduction Fertility and Development 19(1)

      Pages: 195

    • Peer Reviewed
  • [Journal Article] Cloned blastocysts produced by nuclear transfer from somatic cells in cynomolgus monkeys (Macaca fascicularis)2007

    • Author(s)
      Okahara-Narita J, Tsuchiya H, Takada T, Torii R
    • Journal Title

      Primates 48

      Pages: 232-240

    • Peer Reviewed
  • [Journal Article] Laparoscopic evaluation of ovarian reaction to hormone in cynomolgus monkey(Macaca Fascicularis)2006

    • Author(s)
      Iwatani C, Yamasaki J, Tsuchiya H, Okahara N, Narita J, Takada T, Torii R
    • Journal Title

      Exp Anim 5(53)

      Pages: 304

    • Peer Reviewed
  • [Presentation] Evaluation of various gonadotropins for oocytes collection in Cynomolgus monkeys(Macaca fascicularis)2009

    • Author(s)
      Tshuchiya H, Iwatani C, Yamasaki J, Okahara N, Terakado I, Narita J, Torii R
    • Organizer
      The XIIth AAAP Animal Science Congress 2006
    • Place of Presentation
      Busan, Korea
    • Year and Date
      20090918-22
  • [Presentation] Abnormal distribution of cortical granules in monkey one-day old MII oocytes which were immature at oocyte retrival after controlled ovarian hyperstimulation2008

    • Author(s)
      Yamanaka M, Hashimoto S, Okahara J, Yamasaki J, Torii R, Morimoto R
    • Organizer
      American Society for Reproductive Medicine 64th Annual Meeting
    • Place of Presentation
      San Francisco, California, USA
    • Year and Date
      20081108-12
  • [Presentation] カニクイザルにおける単一割球からのES細胞の樹立2008

    • Author(s)
      岡原(成田)純子、山崎樹里、岩谷千鶴、土屋英明、鳥居隆三
    • Organizer
      日本実験動物科学技術2008(第55回日本実験動物学会総会)
    • Place of Presentation
      仙台
    • Year and Date
      20080515-20080517
  • [Presentation] カニクイザル分割クローン個体の作出2008

    • Author(s)
      岩谷千鶴、岡原(成田) 純子、山崎樹里、土屋英明、鳥居隆三
    • Organizer
      日本実験動物科学技術2008(第55回日本実験動物学会総会)
    • Place of Presentation
      仙台
    • Year and Date
      20080515-17
  • [Presentation] A cynomolgus monkey embryonic stem cell line derived from a single blastomere2008

    • Author(s)
      Okahara-Narita J, Yamasaki J, Iwatani C, Tsuchiya H, Torii R.
    • Organizer
      34th Annual Conference of the International Embryo Transfer Society
    • Place of Presentation
      Denver, USA
    • Year and Date
      20080105-20080109
  • [Presentation] Effect of epidermal growth factor on in vitro maturation of cynomolgus monkey (Macaca fascicularis) oocytes2008

    • Author(s)
      Yamasaki J, Okahara-Narita J, Iwatani C, Tsuchiya H, Torii R.
    • Organizer
      34th Annual Conference of the International Embryo Transfer Society
    • Place of Presentation
      Denver, USA
    • Year and Date
      20080105-20080109
  • [Presentation] Influence of hoechst staining for nuclear transfer on parthenogenetic embryos in cynomolgus monkey (Macaca fascicularis)2008

    • Author(s)
      Tsuchiya H, Iwatani C, Okahara-Narita J, Yamasaki J, Torii R.
    • Organizer
      34th Annual Conference of the International Embryo Transfer Society
    • Place of Presentation
      Denver, USA
    • Year and Date
      20080105-20080109
  • [Presentation] Clonal offspring derived from separated blastomeres in cynomolgus monkey (Macaca fascicularis)2008

    • Author(s)
      Iwatani C, Okahara-Narita J, Yamasaki J, Tsuchiya H, Torii R.
    • Organizer
      34th Annual Conference of the International Embryo Transfer Society
    • Place of Presentation
      Denver, USA
    • Year and Date
      20080105-20080109
  • [Presentation] カニクイザル分割胚によるクローン個体の作出2008

    • Author(s)
      岩谷千鶴、岡原純子、山崎樹里、土屋英明、鳥居隆三
    • Organizer
      日本生殖再生医学会第3回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-30
  • [Presentation] カニクイザルにおける効率よい核移植法の検討2008

    • Author(s)
      岡原純子、岩谷千鶴、山崎樹里、土屋英明、鳥居隆三
    • Organizer
      日本生殖再生医学会第3回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-30
  • [Presentation] Establishument of cynomolgus monkey embryonic stem cell line from a single blastomere2007

    • Author(s)
      Okahara-Narita J, Yamasaki J, Iwatani C, Tsuchiya H, Wakimoto K, Kondo Y, Wakayama T, Torii R.
    • Organizer
      The Fourth Annual Conference of the Asian Reproductive Biotechnology
    • Place of Presentation
      Society, Singapore
    • Year and Date
      20071124-20081128
  • [Presentation] 単為発生胚の発生を指標としたカニクイザル体細胞核移植法の検討2007

    • Author(s)
      岩谷千鶴、岡原純子、山崎樹里、土屋英明、鳥居隆三
    • Organizer
      第54回実験動物学会総会
    • Place of Presentation
      東京
    • Year and Date
      20070523-20070525
  • [Presentation] カニクイザル体細胞核移植胚の早期染色体凝集(PCC)の形成2007

    • Author(s)
      岡原(成田)純子、岩谷千鶴、山崎樹里、土屋英明、鳥居隆三
    • Organizer
      第54回実験動物学会総会
    • Place of Presentation
      東京
    • Year and Date
      20070523-20070525
  • [Presentation] Laparoscopic evaluation of ovarian reaction to hormone stimulation in cynomolgus monkeys (Macaca fascicularis)2007

    • Author(s)
      Tsuthiya H, Iwatani C, Yamasaki J, Okahara J, Okahara N, Torii R.
    • Organizer
      The 33rd Annual Conference of the International Embryo Transfer Society
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20070106-20070110
  • [Presentation] カニクイザル卵子の体外成熟培養2006

    • Author(s)
      山崎樹里、岩谷千鶴、岡原純子、土屋英明、鳥居隆三
    • Organizer
      第92回関西実験動物研究会
    • Place of Presentation
      京都
    • Year and Date
      2006-12-08
  • [Patent(Industrial Property Rights)] 未成熟卵子の体外成熟培養用添加剤及びそれを用いた成熟卵子の作出方法2007

    • Inventor(s)
      櫻川宣男, 鳥居隆三, 小林譲
    • Industrial Property Number
      特許出願2007-165929
    • Filing Date
      2007-06-25

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Published: 2010-06-11   Modified: 2016-04-21  

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