2009 Fiscal Year Final Research Report
Development of a synthetic method of modified histone aiming at elucidation of the molecular mechanism of the gene expression regulation
| Project/Area Number |
18310145
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Osaka University |
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Principal Investigator |
AIMOTO Saburo Osaka University, 蛋白質研究所, 教授 (80029967)
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| Co-Investigator(Kenkyū-buntansha) |
TAJIMA Shoji 大阪大学, 蛋白質研究所, 教授 (50132931)
KAWAKAMI Toru 大阪大学, 蛋白質研究所, 准教授 (70273711)
SUETAKE Isao 大阪大学, 蛋白質研究所, 准教授 (80304054)
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| Project Period (FY) |
2006 – 2009
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| Keywords | ヒストン / メチル化 / 化学合成 / 翻訳後修飾 / 遺伝子発現 / メチル化リシン / ヒストンH3 / ライゲーション法 |
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| Research Abstract |
To establish synthetic methods of histone H3 tail and modified histone H3, we searched methods for modified lysine synthesis, chemical synthesis of modified lysine-containing histone H3 tails, and chemical synthesis of full sequence histone H3. Synthetic modified histone H3 tails contributed to the biochemical elucidation of polycomb repressive complex 2. 9Lys(Me_3)-histone H3 was also synthezised.
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Research Products
(36 results)
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[Presentation] Histone H3K9 trimethylation stimulates the histone H3K27 methylation activity of PRC2 bypassing Eed2010
Author(s)
Isao Suetake, Saburo Aimoto, Yuko Aoki, Kyoichi Isono, Toru Kawakami, Hiroshi Kimura, Akihiko Koseki, Yuichi Mishima; Osamu Nishimura, Shoji Tajima, Makoto Watanabe
Organizer
Keystone symposium
Place of Presentation
Sagebrush Inn and Conference Center, Taos, New Mexico
Year and Date
2010-01-20
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