Mechanisms of Sensory Processing in C. elegans Neuronal Circuits

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18370004
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Genetics/Genome dynamics
• Research Institution: Kyushu University
• Principal Investigator: ISHIHARA Takeshi Kyushu University, 大学院・理学研究院, 教授 (10249948)
• Project Period (FY): 2006 – 2009
• Keywords: 行動遺伝学 / 学習 / 神経回路 / 情報処理 / 線虫

Research Abstract

線虫C. elegansをモデルとした行動遺伝学的解析により神経回路における情報処理機構を解明する。
(1) 感覚情報の統合と連合学習の制御を担うシグナル伝達系を同定し、それが働く神経回路を明らかにする。
(2) 記憶の保持に着目して、記憶の保持時間を制御するメカニズムを明らかにする。
(3) 嗅覚順応におけるRas-MAPK 経路の働きを、介在ニューロンの働きやMAPK が制御する下流因子に着目して明らかにする。
(4) 体内環境に基づき神経機能を制御するメカニズムを明らかにする。

Research Products

• [Journal Article] ADBP-1 regulates an ADAR RNA-editing enzyme to antagonize RNAi-mediated gene silencing in C.elegans (2008)
  • Author(s): Ohta, H., Fujiwara, M., Ohshima, Y., Ishihara and T. Genetics
  • Journal Title: 180 Pages: 785-796
  • Peer Reviewed
• [Journal Article] Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans (2007)
  • Author(s): Bauer Huang,SL., Saheki, Y., Vanhoven, MK., Torayama, I., Ishihara, T., Katsura, I, van der Linden, A., Sengupta, P. and Bargmann, CI.
  • Journal Title: Neural Development 2 Pages: 24
  • Peer Reviewed
• [Journal Article] A Genome-wide Survey and Systematic RNAi-based Characterization of Helicase-like Genes in Caenorhabditis elegans (2007)
  • Author(s): Eki, T., Ishihara ,T., Katsura, I. & Hanaoka, F.
  • Journal Title: DNA Research 14 Pages: 183-199
  • Peer Reviewed
• [Journal Article] Caenorhabditis elegans integrates the signals of butanone and food to enhance chemotaxis to butanone (2007)
  • Author(s): Torayama, I., Ishihara, T., Katsura and I. Journal
  • Journal Title: Neuroscience 27 Pages: 741-750
  • Peer Reviewed
• [Journal Article] IFT-81 and IFT74 are required for intraflagellar transport in C. elegans (2007)
  • Author(s): Kobayashi, T., Gengyo-Ando, K., Ishihara ,T., Katsura, I. and Mitani, S.
  • Journal Title: Genes To Cells 12 Pages: 593-602
  • Peer Reviewed
• [Presentation] 線虫における感覚情報処理の分子機構Molecular mechanisms of sensory processing in C.elegans (2008)
  • Author(s): 石原健
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 20080709-0711
• [Presentation] Molecular Mechanisms Of The Integration Of Two Sensory Signals In C.elegans. NEWRONAL DEVELOPMENT,SYNAPTIC FUNCTION & BEHAVIOR (2008)
  • Author(s): Shinkai,Y., Tsunozaki,M., Bargmann,C. and Ishihara, T.
  • Organizer: C.elegans Topic Meeting #2
  • Place of Presentation: Madison,U.S.A.
  • Year and Date: 20080629-0702
• [Presentation] Molecular mechanisms regulating the sensory integration process in C.elegans (2007)
  • Author(s): 新海陽一、石原健
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 20071211-15
• [Presentation] Genetic analyses of mechanism for memory erasing in Caenorhaditis elegans (2007)
  • Author(s): Inoue, A. and Ishihara, T.
  • Organizer: 16 th International C.elegans meeting Los Angeles
  • Place of Presentation: U.S.A.
  • Year and Date: 20070627-0701
• [Presentation] Genetic analysis of the sensory integration process in the neuronal circuit (2007)
  • Author(s): Shinkai ,Y. and Ishihara, T.
  • Organizer: 16 th International C.elegans meeting Los Angeles
  • Place of Presentation: U.S.A.
  • Year and Date: 20070627-0701
• [Book] 線虫C.elegansにおける連合学習のメカニズム (2007)
  • Author(s): 石原健
  • Total Pages: 587-593
  • Publisher: 共立出版蛋白質核酸酵素増刊「神経の分化, 回路形成, 機能発現」
• [Book] 線虫C,elegansの行動可塑性 (2006)
  • Author(s): 石原健
  • Total Pages: 130-136
  • Publisher: 羊土社「脳機能研究の新展開」実験医学増刊