2009 Fiscal Year Final Research Report
Mechanisms of Sensory Processing in C.elegans Neuronal Circuits.
| Project/Area Number |
18370004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Kyushu University |
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Principal Investigator |
ISHIHARA Takeshi Kyushu University, 大学院・理学研究院, 教授 (10249948)
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| Co-Investigator(Kenkyū-buntansha) |
KOGA Makoto 九州大学, 大学院・理学研究院, 准教授 (60243888)
FUJIWARA Manabi 九州大学, 大学院・理学研究院, 助教 (70359933)
HIROTSU Takaaki 九州大学, 大学院・理学研究院, 助教 (70404035)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 行動遺伝学 / 学習 / 神経回路 / 情報処理 / 線虫 |
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| Research Abstract |
Animals sense variety of environmental stimuli in sensory neurons, simultaneously. This sensory information is processed in central nervous systems to regulate their behavior. In this study, we investigated mechanisms of the sensory processing by using C.elegans as a model organism. We identified signaling pathways to regulate the sensory integration and neuronal circuits where those pathways function. To elucidate the regulation of the memory retention, we isolated mutants showing longer memory retention and thereby identified a signaling pathway that regulates the memory retention. We found that the germline signals regulate the olfactory response. By using this phenomenon, we isolated a mutant defective in the regulation. In addition, we elucidated the function of signaling pathways for the olfactory sensation and behavioral plasticity.
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[Journal Article] Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans.2007
Author(s)
Bauer Huang, SL., Saheki, Y., Vanhoven, MK., Torayama, I., Ishihara, T., Katsura, I, van der Linden, A., Sengupta, P., Bargmann, CI
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Journal Title
Neural Development 2
Pages: 24
Peer Reviewed
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