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2008 Fiscal Year Final Research Report

Studies for mechanisms of gonadotropin gene regulation with novel pituitary transcription factors

Research Project

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Project/Area Number 18380177
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionMeiji University

Principal Investigator

KATO Yukio  Meiji University, 農学部, 教授 (30114177)

Co-Investigator(Renkei-kenkyūsha) KATO Takako  明治大学, 研究知財・戦略機構, 研究員 (90445859)
Project Period (FY) 2006 – 2008
Keywords転写調節因子 / ホメオティック因子 / 性腺刺激ホルモン / 転写因子ネットワーク / 相互作用 / クローニング
Research Abstract

交付期間で、新規転写因子PROP1の特異抗体を作製し、下垂体の発生過程における発現変動を解析し、PROP1が発生初期の下垂体の全細胞に存在し、その後ホルモン産生細胞の出現に伴いその数を減じることを初めて明らかにした。しかも、PROP1陽性細胞は常に細胞分化に重要な因子SOX2と共存する事も初めて明らかした。さらに、新規の転写因子PRX2の同様な解析を行い、PROP1-PRX2-下垂体の分化細胞と言う系譜の一端を明らかにした。

  • Research Products

    (21 results)

All 2009 2008 2007 2006 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Regulation of porcine pituitary glycoprotein hormone alpha subunit gene with LIM-homeobox transcription factor Lhx32009

    • Author(s)
      Susa T, Ishikawa A, Kato T, Nakayama M, Kitahara K, Kato Y.
    • Journal Title

      J Reprod Dev

      Pages: doi : 10.1262jrd.20232.

    • Peer Reviewed
  • [Journal Article] Highly related LIM factors, LMO1, LMO3 and LMO4, play different roles in the regulation of pituitary glycoprotein hormone common α subunit gene2009

    • Author(s)
      Susa T, Ishikawa A, Cai LY, Kato T, Matsumoto K, Kitahara K, Kurokawa R, Ono T, Kato Y.
    • Journal Title

      Biosci Rep 2009

      Pages: doi : 10.1042BSR 20090020

    • Peer Reviewed
  • [Journal Article] Dimeric PROP1 binding to diverse palindromic TAAT sequences promotes its transcriptional activity2009

    • Author(s)
      Nakayama M, Kato T, Susa T, Sano A, Kitahara K, Kato Y
    • Journal Title

      Mol Cell Endocrinol 2009

      Pages: doi : 10.1016/j.mce.2009.03. 010

    • Peer Reviewed
  • [Journal Article] Intracellular localization of porcine single-strand binding protein 22009

    • Author(s)
      Kato Y Kato T, Ono T, Susa T, Kitahara K, Matsumoto K.
    • Journal Title

      J Cell Biochem 2009 106

      Pages: 912-919

    • Peer Reviewed
  • [Journal Article] Molecular cloning and characterization of porcine homeodomain transcription factor Msx12009

    • Author(s)
      Ishikawa A, Susa T, Kato T, Sano A, Kato Y.
    • Journal Title

      J Reprod Dev 2009

      Pages: doi : 10.1262/jrd. 20179.

    • Peer Reviewed
  • [Journal Article] HSV type 1 thymidine kinase protein accumulation in round spermatids induces male infertility by spermatogenesis disruption and apoptic loss of germ cells2009

    • Author(s)
      Cai LY, Kato T, Nakayama M, Susa T, Izumi SI, Kato T
    • Journal Title

      Reprod Toxicol 2009 27

      Pages: 14-21

    • Peer Reviewed
  • [Journal Article] Cloning and characterization of porcine CArG Binding factor A expressing in the anterior pituitary2008

    • Author(s)
      Takahashi J, Ishikawa A, Susa T, Kato T, Kato Y
    • Journal Title

      J Reprod Dev 2008 54

      Pages: 424-430

    • Peer Reviewed
  • [Journal Article] Reproducible transfection in the presence of carrier DNA using FuGENE6 and Lipofectamine20002008

    • Author(s)
      Susa T, Kato T, Kato Y
    • Journal Title

      Mol Biol Rep 2008 35

      Pages: 313-319

    • Peer Reviewed
  • [Journal Article] 転写因子のDNA結合特性の解析法 : Systematic Evolution of Ligands by EXponential Enrichment(SELEX)2008

    • Author(s)
      中山美智枝、加藤たか子、加藤幸雄
    • Journal Title

      明治大学農学部研究報告 58

      Pages: 19-23

    • Peer Reviewed
  • [Journal Article] 転写因子による下垂体前葉ホルモン産生細胞の分化とホルモン遺伝子の発現制御-生殖腺刺激ホルモン刺激ホルモン遺伝子の発現調節機構2008

    • Author(s)
      諏佐崇生、加藤たか子、加藤幸雄.
    • Journal Title

      明治大学農学部研究報告 57

      Pages: 99-108

    • Peer Reviewed
  • [Journal Article] Analysis of genes expressing during porcine fetal pituitary development by suppressive subtraction hybridization2007

    • Author(s)
      Takahashi J, Susa T, Sato T, Asano H, Kato T, Kato Y
    • Journal Title

      J Reprod Dev2007 53

      Pages: 1087-1091

    • Peer Reviewed
  • [Journal Article] Homeodomain transcription factor Hesx1/Rpx occupies Prop-1 activation sites in porcine follicle stimulating hormone(FSH)beta subunit promoter2007

    • Author(s)
      Susa T, Nakayama M, Kitahara K, Kimoto F, Kato T, Kato Y
    • Journal Title

      Biochem Biophys Res Commun 2007 357

      Pages: 712-717

    • Peer Reviewed
  • [Journal Article] Expression of porcine FSHβ subunit promoter-driven herpes simplex virus thymidine kinase gene in transgenic rats2007

    • Author(s)
      Cai LY, Kato T, Ito K, Nakayama M, Susa T, Aikawa S, Maeda KI, Tsukamura H, Ohta A, Izumi SI, Kato Y
    • Journal Title

      J Reprod Dev 2007 53

      Pages: 201-209

    • Peer Reviewed
  • [Journal Article] Molecular cloning and expression of dead end homologue in chicken primordial germ cells2007

    • Author(s)
      Aramaki S, Sato F, Kato T, Soh T, Kato Y, Hattori MA.
    • Journal Title

      Cell Tissue Res 2007 330

      Pages: 45-52

    • Peer Reviewed
  • [Journal Article] Cofactor CLIM2 promotes the repressive action of LIM homeodomain transcription factor Lhx2 in the expression of porcine pituitary glycoprotein hormone alpha subunit gene2006

    • Author(s)
      Susa T, Sato T, Ono T, Kato T, Kato Y.
    • Journal Title

      Biochem Biophys Acta 2006 1759

      Pages: 403-409

    • Peer Reviewed
  • [Journal Article] Pituitary transcription factor Prop-1 stimulates porcine pituitary glycoprotein hormone a gene expression2006

    • Author(s)
      Sato T, Kitahara K, Susa T, Kato T, Kato Y
    • Journal Title

      J Mol Endocrinol 2006 37

      Pages: 341-352

    • Peer Reviewed
  • [Journal Article] Lhx2 activates porcine FSHβ gene expression by sharing its binding sites with Lhx32006

    • Author(s)
      Kitahara K, Sato T, Kato T, Kato Y
    • Journal Title

      The 88th Endocrine Society Meeting 2006, Boston 692

    • Peer Reviewed
  • [Journal Article] High level expression of prop-1 gene in gonadotropic cell lines2006

    • Author(s)
      Aikawa S, Sato T, Ono Kato T, Kato Y
    • Journal Title

      J Reprod Dev 2006 52

      Pages: 195-201

    • Peer Reviewed
  • [Book] 下垂体腫瘍の実験モデル(「下垂体腫瘍のすべて」寺本明・長村義之編)

    • Author(s)
      加藤幸雄、加藤たか子
    • Total Pages
      (印刷中)
    • Publisher
      医学書院
  • [Remarks] 日本下垂体研究会第6回吉村賞(加藤幸雄)、第13回明治大学駿台会賞(加藤幸雄)、第21回日本下垂体研究会学術集会・優秀発賞受賞(佐藤崇信), 第22回日本下垂体研究会学術集会・優秀発賞受賞(佐野亜希子), 第23回日本下垂体研究会学術集会・優秀発賞受賞(吉田彩舟)

    • URL

      http://www.isc.meiji.ac.jp/~kasuitai/

  • [Patent(Industrial Property Rights)] FSHβ鎖高生産性細胞の作製方法2006

    • Inventor(s)
      加藤幸雄(明治大学)
    • Industrial Property Number
      2006-124700
    • Filing Date
      2006-04-28

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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