Based on the relationship of macrophages-myofibroblasts, the pathogenesis of renal fibrosis and its therapeutic strategies

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18380188
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Clinical veterinary science
• Research Institution: Osaka Prefecture University
• Principal Investigator: YAMATE Jyoji Osaka Prefecture University, 大学院・生命環境科学研究科, 教授 (50150115)
• Project Period (FY): 2006 – 2009
• Keywords: 病態 / 病理発生 / 応用動物学 / 腎線維化モデル / マクロファージ / 筋線維芽細胞

Research Abstract

腎線維化の形成において重要な役割を担うマクロファージと筋線維芽細胞の特性を多角的に解析するとともに、これら細胞の相互関連を基軸とした病理発生機序を解明し、その機序に基づいた新たな治療法を探索する。さらに、線維化病変である肝線維化と皮膚の創傷線維化病変を同様の方法で解析し、腎線維化の発生機序を比較病理学的に解明する。

Research Products

• [Journal Article] Participation of functionally-different macrophage populations and monocyte chemoattractant protein-1 in early stages of thioacetamide-induced rat hepatic injury (2009)
  • Author(s): Mori Y, Izawa T, Takenaka S, Kuwamura M and Yamate J.
  • Journal Title: Toxicol Pathol (in press)
  • Peer Reviewed
• [Journal Article] Macrophage populations and expressions of regulatory proinflammatory factors in the rat meninx under lipopolysaccharide treatment in vivo and in vitro (2009)
  • Author(s): Yamate J, Ishimine S, Izawa T, Kumagai D and Kuwamura M.
  • Journal Title: Histol Histopathol 24(1) Pages: 13-24
  • Peer Reviewed
• [Journal Article] Effect of polyphenol-containing azuki bean (Vigna angularis) extract on blood pressure elevation and macrophage infiltration in the heart and kidney of spontaneously hypertensive rats (2008)
  • Author(s): Sato S, Mukai Y, Yamate J, Kato J, Kurasaki M, Hatai A and Sagai M.
  • Journal Title: Clin Exp Pharmacol Physiol 35(1) Pages: 43-49
  • Peer Reviewed
• [Journal Article] Heterogeneity of macrophage populations and myofibroblasts appearing in rat renal interstitial fibrosis (review) (2007)
  • Author(s): Yamate J.
  • Journal Title: J Toxicol Pathol. 20(4) Pages: 185-195
  • Peer Reviewed
• [Journal Article] Adipogenic, osteogenic and myofibrogenic differentiations of a rat malignant fibrous histiocytoma (MFH)-derived cell line, and a relationship of MFH cells with embryonal mesenchymal, perivascular and bone marrow stem cells (2007)
  • Author(s): Yamate J, Ogata K, Yuasa T, Kuwamura M, Takenaka S, Kumagai D, Itoh K and LaMarre J.
  • Journal Title: Eur J Cancer. 43(18) Pages: 2747-2756
  • Peer Reviewed
• [Presentation] Macrophage appearance and monocyte chemoattractant protein-1 in thioacetamide-induced rat hepatic injury (2008)
  • Author(s): Yamate J, Mori Y, zawa T, Takenaka S and Kuwamura M.
  • Organizer: The 27th Annual Meeting of the Society of Toxicologic Pathology (STP)
  • Place of Presentation: San Francisco
  • Year and Date: 20080622-26
• [Presentation] 慢性腎不全猫に対するACE阻害剤の具体的な使い方-腎間質線維化の面から-腎線維化の進展機序 : マクロファージと筋線維芽細胞の役割, ならびに実験モデルを用いたACE阻害剤の効果 (2007)
  • Author(s): 山手丈至
  • Organizer: 第28回動物臨床医学会年次大会
  • Place of Presentation: 大阪
  • Year and Date: 20071117-18
• [Presentation] シスプラチン誘発急性腎傷害モデルにおけるCOX-2の発現と再生尿細管との係わり (2007)
  • Author(s): 山本絵美, 山手丈至, 井澤武史, 桑村充, 小谷猛夫
  • Organizer: 第143回日本獣医学会学術集会
  • Place of Presentation: つくば
  • Year and Date: 20070403-20070405
• [Presentation] ラットの腎線維化と腎発生におけるThy-1発現細胞の分布と特性解析 (2006)
  • Author(s): 湯浅隆宏, 山手丈至, 井澤武史, 桑村充, 小谷猛夫
  • Organizer: 第142回日本獣医学会学術集会
  • Place of Presentation: 山口
  • Year and Date: 20060922-20060924
• [Presentation] Renal interstitial fibrosis in neonatal rats induced by cisplatin (2006)
  • Author(s): Yamate Y, Machida Y, Kuwamura M, Kotani T.
  • Organizer: The 24th European Society of Veterinary Pathology (ESVP)
  • Place of Presentation: Edinburgh
  • Year and Date: 20060830-0902
• [Remarks] 山手丈至. 肝臓における線維化の病理発生. 2007 年7 月5 日. 徳島県 鳴門 大塚製薬工業株式会社
• [Remarks] 山手丈至. ラット腫瘍モデルの確立と応用:特に, 線維化(腎線維化・肝硬変)の病理発生に向けた応用性の探索. 2007 年6 月26日. 麻布大学 生物科学総合研究所