2009 Fiscal Year Final Research Report
A Comprehensive Study of Pathological Significance of Atypical Cytosine Methylation during Tumorigenesis and Progression
| Project/Area Number |
18390114
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
MAEDA Sakan Kobe University, 大学院・医学研究科, 戦略的客員教授 (50030911)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KITAZAWA Sohei 神戸大学, 大学院・医学研究科, 特命教授 (90186239)
KITAZAWA Riko 神戸大学, 大学院・医学研究科, 特命講師 (00273780)
KONDO Takeshi 神戸大学, 大学院・医学研究科, 特命講師 (20335441)
|
|---|
| Project Period (FY) |
2006 – 2009
|
| Keywords | エピジェネティクス / in situ hybridization |
|---|
| Research Abstract |
While cytosine methylation in CpG-island, located usually regulatory region of many genes, is well recognized as an inhibitory epigenetic regulator, biological significance of the cytosine methylation other than CpG-island is unclear. By focusing morphology-oriented microscopic dissection methods, we investigated cytosine methylation status in the gene promoter, and found that some of the cytosine methylation outside of the CpG-island have major contributions during cancer progression.
|
Research Products
(21 results)
-
-
-
-
[Journal Article] FSP27 Contributes to Efficient Energy Storage in Murine White Adipocytes by Promoting the Formation of Unilocular Lipid Droplets2008
Author(s)
Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, Inoue K, Kitazawa R, Kitazawa S, Matsuki Y, Hiramatsu R, Masubuchi S, Omachi A, Kimura K, Saito M, Amo T, Ohta S, Yamaguchi T, Osumi T, Cheng J, Fujimoto T, Nakao H, Nakao K, Aiba A, OkaNishino N, Tamori Y, Tateya
-
Journal Title
J Clin Invest 118
Pages: 2808-2821
Peer Reviewed
-
-
-
-
[Journal Article] Hepatic failure and enhanced oxidative stress in mitochondrial diabetes2008
Author(s)
Takahashi Y, Iida K, Takeno R, Kitazawa R, Kitazawa S, Kitamura H, Fujioka Y, Yamada H, Kanda F, Ohta S, Nishimaki K, Fujimoto M, Kondo T, Iguchi G, Takahashi K, Kaji H, Okimura Y, Chihara K
-
Journal Title
Endocr J 55
Pages: 509-14
Peer Reviewed
-
-
-
-
-
-
[Journal Article] MCP-1 Contributes to Macrophage Infiltration into Adipose Tissue, Insulin Resistance, and Hepatic Steatosis in Obesity2006
Author(s)
Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K, Kasuga M
-
Journal Title
J Clin Invest 116
Pages: 1494-1505
Peer Reviewed
-
-
-
-
-
-
-
