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2008 Fiscal Year Final Research Report

THE STUDY OF REAL-TIME LIVING BODY MONITORING USING CARBON NANOTUBE SENSOR

Research Project

  • PDF
Project/Area Number 18390170
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionHokkaido University

Principal Investigator

CHIBA Hitoshi  Hokkaido University, 大学院・保健科学研究院, 教授 (70197622)

Co-Investigator(Kenkyū-buntansha) ISHII Kojiro  同志社大学, スポーツ健康科学部, 教授 (30243520)
MUKASA Koichi  北海道大学, 創成科学共同研究機構, 特任教授 (00001280)
Co-Investigator(Renkei-kenkyūsha) ISHII Kojiro  同志社大学, スポーツ健康科学部, 教授 (30243520)
Project Period (FY) 2006 – 2008
Keywordsカーボンナノチューブ / バイオセンサー / 乳酸 / 酸化ストレス
Research Abstract

高齢者でも乳酸閾値レベル(疲労物質の乳酸が蓄積しはじめる直前のレベル)の運動を持続すると体力向上が得られる。そのために手軽に血中の乳酸値を運動中に測定できる簡便な測定装置が求められている。また、高齢者は抗酸化能が低下するため、酸化ストレスレベルを測定して動脈硬化防止策を講じる必要がある。本研究で開発したカーボンナノチューブセンサーは、乳酸や酸化ストレスレベルを簡便に測定できる。

  • Research Products

    (16 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (5 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Lipoprotein metabolism, insulin resistance, and adipocytokine levels in Japanese female adolescents with a normal body mass index and high body fat mass2009

    • Author(s)
      Kishimoto N, Okita K, Takada S, Sakuma I, Sajo Y, Chiba H, Ishii K, Kishi R, Tsutsumi H.
    • Journal Title

      Circ J 73

      Pages: 534-539

    • Peer Reviewed
  • [Journal Article] Lipoprotein profiles in children with two common cholesteryl ester transfer protein gene mutations, D442G and 114A during the first year of life2009

    • Author(s)
      Nagasaka H, Yorifuji T, Momoi T, Yorifuji J, Hirano K, Ota A, Takatani T, Tsukahara H, Takayanagi M, Kobayashi K, Chiba H, Sato Y, Miida T.
    • Journal Title

      Clin Chim Acta 406

      Pages: 52-56

    • Peer Reviewed
  • [Journal Article] Elevated plasma plasminogen activator inhibitor-1 in CD36 deficiency2008

    • Author(s)
      Yanai H, Chiba H, Matsuno K.
    • Journal Title

      Diabetes Care 31

      Pages: e72-e72

    • Peer Reviewed
  • [Journal Article] Reduced apolipoprotein E-rich high-density lipoprotein level at birth is restored to the normal range in patients with familial hypercholesterolemia in the first year of life2008

    • Author(s)
      Nagasaka H, Miida T, Hirano K, Ota A, Yorifuji T, Takatani T, Tsukahara H, Takayanagi M, Hui SP, Kobayashi K, Chiba H.
    • Journal Title

      J Clin Endocrinol Metab 93

      Pages: 779-783

    • Peer Reviewed
  • [Journal Article] Fluctuation of lipoprotein metabolism linked with bile acid-activated liver nuclear receptors in Alagille syndrome2008

    • Author(s)
      Nagasaka H, Miida T, Hirano KI, Ota A, Murayama K, Yorifuji T, Kobayashi K, Takatani T, Tsukahara H, Hui SP, Takayanagi M, Chiba H.
    • Journal Title

      Atherosclerosis 198

      Pages: 434-440

    • Peer Reviewed
  • [Journal Article] Increased Fructose 2, 6-bisphosphate in Peripheral Blood Mononuclear Cells of Patients with Diabetes2007

    • Author(s)
      Atsumi T, Chiba H, Yoshioka N, Bucala R, Koike T
    • Journal Title

      Endocr J 54

      Pages: 517-520

    • Peer Reviewed
  • [Journal Article] Attenuated aerobic exercise capacity in CD36 deficiency2007

    • Author(s)
      Yanai H, Watanabe I, Ishii K, Morimoto M, Fujiwara H, Yoshida S, Hui SP, Matsuno K, Chiba H.
    • Journal Title

      J Med Genet. 44

      Pages: 445-447

    • Peer Reviewed
  • [Journal Article] Depletion of High-density Lipoprotein and Appearance of Triglyceride-rich Low-density Lipoprotein in a Japanese Patient With FIC1 Deficiency Manifesting Benign Recurrent Intrahepatic Cholestasis2007

    • Author(s)
      Hironori Nagasaka, Hitoshi Chiba, Shu-Ping Hui, Hajime Takikawa, Takashi Miida, Masaki Takayanagi, Tohru Yorifuji, Makoto Hasegawa, Akemi Ota, Ken-ichi Hirano, Hideaki Kikuchi, Hirokazu Tsukahara, Kunihiko Kobayashi
    • Journal Title

      J Pediatr Gastroenterol Nutr 45

      Pages: 96-105

    • Peer Reviewed
  • [Journal Article] An Improved HPLC Assay for Phosphatidylcholine Hydroperoxides (PCOOH) in Human Plasma with synthetic PCOOH as Internal Standard2007

    • Author(s)
      Shu-Ping Hui, Hitoshi Chiba, Toshihiro Sakurai, Chitose Asakawa, Hironori Nagasaka, Tsuyoshi Murai, Hajime Ide, Takao Kurosawa
    • Journal Title

      Journal of Chromatography B 857

      Pages: 158-163

    • Peer Reviewed
  • [Journal Article] Angiotensin I converting enzyme gene polymorphism and exercise trainability in elderly women : An electrocardiological approach2007

    • Author(s)
      Tobina T, Kiyonaga A, Akagi Y, Mori Y, Ishii K, Chiba H, Shindo M, Tanaka H.
    • Journal Title

      J Clin Spports Scie Med 6

      Pages: 22-226

    • Peer Reviewed
  • [Presentation] カーボンナノチューブ-バイオセンサーを用いた乳酸の測定2009

    • Author(s)
      千葉仁志, ほか
    • Organizer
      日本臨床化学会年次学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2009-09-18
  • [Presentation] 「転換期を迎えた脂質検査」(教育講演)2009

    • Author(s)
      千葉仁志
    • Organizer
      日本臨床化学会年次学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2009-09-18
  • [Presentation] 新しい脂質の時代」(ランチョンセミナー)2009

    • Author(s)
      千葉仁志
    • Organizer
      日本臨床検査医学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-28
  • [Presentation] カーボンナノチューブ-バイオセンサーを用いた乳酸の測定2009

    • Author(s)
      千葉仁志, 武笠幸一, ほか
    • Organizer
      日本臨床検査医学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-28
  • [Presentation] 「大きな変革の時代に来た脂質・リポ蛋白検査」(シンポジウム)2009

    • Author(s)
      千葉仁志
    • Organizer
      日本医学検査学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-07-31
  • [Patent(Industrial Property Rights)] CNTセンサーによる過酸化物を電気的に測定する方法2009

    • Inventor(s)
      千葉仁志, 武田晴治, 石井睦, 中村基訓, 武笠幸一, 惠淑萍, 黒澤隆夫
    • Industrial Property Rights Holder
      国立大学法人 北海道大学, 惠淑萍 (北海道医療大学), 黒澤隆夫 (北海道医療大学)
    • Industrial Property Number
      2009-169126
    • Filing Date
      2009-07-17

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Published: 2011-06-18   Modified: 2014-04-07  

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