Study of pathogenesis and pathophysiology of epilepsy using genetic model harboring epileptic mutation

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18390316
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Mie University (2007-2009); Hirosaki University (2006)
• Principal Investigator: OKADA Motohiro Mie University, 大学院・医学系研究科, 教授 (10281916)
• Project Period (FY): 2006 – 2009
• Keywords: てんかん / 遺伝子 / 分子生物学 / 神経伝達

Research Abstract

(1) 同定された中枢神経系機能性疾患の責任遺伝子を導入した遺伝子改変モデル動物の作出。
(2) 作出された遺伝子改変モデル動物が、ヒト機能性疾患のモデル動物としての妥当性検証
(3) モデル動物としての妥当性が検証された、ヒト中枢神経系機能性疾患の責任遺伝子導入遺伝子改変モデル動物を用いた、病態解析

Research Products

• [Journal Article] Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype (2008)
  • Author(s): Zhu G, Okada M, Yoshida S, Ueno S, Mori F, Takahara T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H, Kijima H, Takano Y, Mitsudome A, Kaneko S, Hirose S.
  • Journal Title: J Neurosci 28 Pages: 12465-12476
  • Peer Reviewed
• [Journal Article] Carbamazepine prevents breakdown of neurotransmitter release induced by hyperactivation of ryanodine receptor (2007)
  • Author(s): Yoshida S, Okada M, Zhu G, Kaneko S
  • Journal Title: Neuropharmacology 52 Pages: 1538-1546
  • Peer Reviewed
• [Journal Article] Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex (2007)
  • Author(s): Yamada J, Furukawa T, Ueno S, Yamamoto S, Fukuda A
  • Journal Title: Cereb Cortex 17 Pages: 1782-1787
  • Peer Reviewed
• [Journal Article] Insertion of alpha7 nicotinic receptors at neocortical layer V GABAergic synapses is induced by a benzodiazepine, midazolam (2007)
  • Author(s): Yamamoto S, Yamada J, Ueno S, Kubota H, Furukawa T, Fukuda A
  • Journal Title: Cereb Cortex 17 Pages: 653-660
  • Peer Reviewed
• [Journal Article] Effects of interleukin-1beta on hippocampal glutamate and GABA releases associated with Ca2+-induced Ca2+ releasing systems (2006)
  • Author(s): Zhu G, Okada M, Yoshida S, Mori F, Ueno S, Wakabayashi K, Kaneko S
  • Journal Title: Epilepsy Res 71 Pages: 107-116
  • Peer Reviewed
• [Patent(Industrial Property Rights)] けいれん性疾患に関連する遺伝子変異とけいれん性疾患診断方法 (2006)
  • Inventor(s): 小島俊男・廣瀬伸一・岡田元宏・兼子直
  • Industrial Property Rights Holder: 国立大学法人弘前大学・独立行政法人理化学研究所・学校法人福岡大学
  • Patent Publication Number: 特開2006-325500(P2006-325500A)
  • Acquisition Date: 2006-12-07