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2008 Fiscal Year Final Research Report

Studies on the mechanisms of dyspnea in terminal cancer patients and for establishment of a new therapy for dyspnea

Research Project

  • PDF
Project/Area Number 18390425
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionChiba University

Principal Investigator

NISHNIO Takashi  Chiba University, 大学院・医学研究院, 教授 (80009703)

Co-Investigator(Kenkyū-buntansha) NAHO Iiyori  千葉大学, 医学部付属病院, 助教 (10400970)
Project Period (FY) 2006 – 2008
Keywords呼吸困難 / 末期がん患者 / トロメタモール / 性差
Research Abstract

呼吸困難感に影響を与えると考えられている様々な要因に検討を加え、以下の結論を得た.1)呼吸困難感の質を識別するものとは別に量的な差を識別できる中枢機構が存在する.2)トロメタモール(THAM)は呼吸性アシドーシスを是正すると同時に呼吸困難感を緩和し、呼吸困難緩和に有用である.3)呼吸困難と痺痛が同時に存在する場合、呼吸困難が痔痛に及ぼす影響には性差が存在し、この性差に吸気努力に伴う呼吸系力学変化が関与する.

  • Research Products

    (14 results)

All 2009 2008 2007 2006

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results) Book (3 results)

  • [Journal Article] Aggravation of dyspnea by cough-Vagal mechanisms2009

    • Author(s)
      Nishino T
    • Journal Title

      Pulm Pharmacol Ther 22

      Pages: 102-107

    • Peer Reviewed
  • [Journal Article] Coughing induced by airway irritation modulates the sensation of air hunger2008

    • Author(s)
      Nishino T, Isono S, Shinozuka N, Ishikawa T
    • Journal Title

      J Physiol 586.2

      Pages: 649-658

    • Peer Reviewed
  • [Journal Article] Sex differences in the effect of dyspnea on thermal pain threshold in young healthy subjects2008

    • Author(s)
      Nishino T, Isono S, Ishikawa T, Shinozuka N
    • Journal Title

      Anesthesiology 109

      Pages: 1100-1106

    • Peer Reviewed
  • [Journal Article] Pathophysiology of dyspnea evaluated by breath-holding test2008

    • Author(s)
      Nishino T
    • Journal Title

      studies of furosemide treatment Respiratory Physiology & Neurobiol

      Pages: Nov 25

    • Peer Reviewed
  • [Journal Article] 呼吸生理の基礎と臨床2008

    • Author(s)
      西野卓
    • Journal Title

      日本臨床麻酔学会誌 28

      Pages: 711-721

    • Peer Reviewed
  • [Journal Article] An additive interaction between different qualities of dyspnea produced in normal human subjects2007

    • Author(s)
      Nishino T, Isono S, Ishikawa T, Shinozuka N
    • Journal Title

      Respir Physiol & Neurobiol 155

      Pages: 14-21

    • Peer Reviewed
  • [Presentation] Cough and dyspnea2008

    • Author(s)
      Nishino T
    • Organizer
      5th International Symposium on cough
    • Place of Presentation
      London
    • Year and Date
      20080626-28
  • [Presentation] 呼吸困難の生理2008

    • Author(s)
      西野卓
    • Organizer
      第28回日本臨床麻酔学会臨床麻酔学会
    • Place of Presentation
      京都
    • Year and Date
      2008-11-20
  • [Presentation] 呼吸生理の基礎と臨床2007

    • Author(s)
      西野卓
    • Organizer
      第27回日本臨床麻酔学会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-25
  • [Presentation] だから呼吸は面白い2007

    • Author(s)
      西野卓
    • Organizer
      日本麻酔科学会リフレシャーコース
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-02
  • [Presentation] 上気道反射の役割2006

    • Author(s)
      西野卓
    • Organizer
      国際歯科麻酔学会
    • Place of Presentation
      横浜
    • Year and Date
      2006-10-05
  • [Book] 最新整形外科体系第9巻周術期管理, リスク管理, 疼痛管理(呼吸系モニタリング, 糸満盛憲, 外須美夫)2008

    • Author(s)
      西野卓、篠塚典弘
    • Total Pages
      116-124
    • Publisher
      中山書店
  • [Book] 全身麻酔中の換気、麻酔実践テキスト(武田純三, 森田茂穂)2008

    • Author(s)
      西野卓
    • Total Pages
      133-135
    • Publisher
      南江堂
  • [Book] 周術期の呼吸管理2007

    • Author(s)
      西野卓
    • Total Pages
      263
    • Publisher
      克誠堂出版社

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Published: 2010-06-10   Modified: 2016-04-21  

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