2010 Fiscal Year Final Research Report
Isolation of maltipotent stem cells from keloids
| Project/Area Number |
18390477
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
SUZUKI Shigehiko Kyoto University, 医学研究科, 教授 (30187728)
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| Co-Investigator(Kenkyū-buntansha) |
UTANI Atsushi 京都大学, 医学研究科, 准教授 (10292707)
NAITOH Motoko 京都大学, 医学研究科, 講師 (30378723)
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| Project Period (FY) |
2006 – 2010
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| Keywords | ケロイド / 創傷治癒 / 幹細胞 |
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| Research Abstract |
We obtained multipotent precursor cells derived from keloid tissues. We found that gene B over-expressed in keloid derived precursor cells, plays a crucial role in keloid pathogenesis, because this gene is closely concerned with up-regulation of collagen gene expression. We propose that both of keloid derived precursor cells and gene B may be a good target for a novel therapy.
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