2009 Fiscal Year Final Research Report
Affinity chemical modification and functional control onto carbonate-apatite composite scaffolds
| Project/Area Number |
18390515
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Hiroshima University |
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Principal Investigator |
OKAZAKI Masayuki Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (30107073)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Isao 広島大学, 大学院・医歯薬学総合研究科, 助教 (40346507)
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| Co-Investigator(Renkei-kenkyūsha) |
AKAGAWA Yasumasa 広島大学, 大学院・医歯薬学総合研究科, 教授 (00127599)
NOMURA Yuji 広島大学, 大学院・医歯薬学総合研究科, 助教 (80218370)
OBARA Masanobu 広島大学, 大学院・理学研究科, 准教授 (60132479)
MATSUURA Nariaki 大阪大学, 大学院・医学研究科, 教授 (70190402)
MATSUMOTO Takuya 大阪大学, 大学院・歯学研究科, 講師 (40324793)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 炭酸アパタイト / スカフォールド / 骨再生 / 化学修飾 / 機能制御 |
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| Research Abstract |
To develop a new biodegradable scaffold biomaterial, bone-like carbonate apatites (CO_3Ap) were synthesized and CO_3Ap-collagen scaffolds were created. When these sponge-frame complexes with rh-BMP2 were implanted beneath the periosteum cranii of rats, sufficient new bone was created at the surface of the periosteum cranii after 4 wks' implantation. Furthermore, when the CO_3Ap-collagen sponge containing SVVYGLR peptide was implanted as a graft into a tissue defect created in rat tibia, the migration of numerous vascular endothelial cells as well as prominent angiogenesis inside the graft could be detected after 1 week. Thus, the modification of higher function such as cytokine and angiogenesis factors is effective for low regeneration region as tissue engineering biomaterials.
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[Journal Article] Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials.2007
Author(s)
Hamada Y., Egusa H., Kaneda Y., Hirata I., Kawaguchi N., Hirao T., Matsumoto T., Yao M., Daito K., Suzuki M., Yatani H., Daito M., Okazaki M., Matsuura N
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Journal Title
Dent Mater J 26
Pages: 487-492
Peer Reviewed
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