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2009 Fiscal Year Final Research Report

Affinity chemical modification and functional control onto carbonate-apatite composite scaffolds

Research Project

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Project/Area Number 18390515
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionHiroshima University

Principal Investigator

OKAZAKI Masayuki  Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (30107073)

Co-Investigator(Kenkyū-buntansha) HIRATA Isao  広島大学, 大学院・医歯薬学総合研究科, 助教 (40346507)
Co-Investigator(Renkei-kenkyūsha) AKAGAWA Yasumasa  広島大学, 大学院・医歯薬学総合研究科, 教授 (00127599)
NOMURA Yuji  広島大学, 大学院・医歯薬学総合研究科, 助教 (80218370)
OBARA Masanobu  広島大学, 大学院・理学研究科, 准教授 (60132479)
MATSUURA Nariaki  大阪大学, 大学院・医学研究科, 教授 (70190402)
MATSUMOTO Takuya  大阪大学, 大学院・歯学研究科, 講師 (40324793)
Project Period (FY) 2006 – 2009
Keywords炭酸アパタイト / スカフォールド / 骨再生 / 化学修飾 / 機能制御
Research Abstract

To develop a new biodegradable scaffold biomaterial, bone-like carbonate apatites (CO_3Ap) were synthesized and CO_3Ap-collagen scaffolds were created. When these sponge-frame complexes with rh-BMP2 were implanted beneath the periosteum cranii of rats, sufficient new bone was created at the surface of the periosteum cranii after 4 wks' implantation. Furthermore, when the CO_3Ap-collagen sponge containing SVVYGLR peptide was implanted as a graft into a tissue defect created in rat tibia, the migration of numerous vascular endothelial cells as well as prominent angiogenesis inside the graft could be detected after 1 week. Thus, the modification of higher function such as cytokine and angiogenesis factors is effective for low regeneration region as tissue engineering biomaterials.

  • Research Products

    (26 results)

All 2010 2009 2008 2007 2006

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (19 results) Book (2 results)

  • [Journal Article] Bone formation ability of carbonate apatite-collagen scaffolds with different carbonate contents.2009

    • Author(s)
      Matsuura A., Kubo T., Doi K., Hayashi K., Morita K., Yokota R., Hayashi H., Hirata I., Okazaki M., Akagawa. Y
    • Journal Title

      Dent Mater J 28

      Pages: 234-242

    • Peer Reviewed
  • [Journal Article] Influence of the chemical structure of functional monomers on their adhesive performance.2008

    • Author(s)
      Van Landuyt K.L., Yoshida, Y., Hirata I., Snauwaert J., De Munck J., Okazaki M., Suzuki K., Lambrechts P., Van Meerbeek B
    • Journal Title

      J Dent Res 87

      Pages: 757-761

    • Peer Reviewed
  • [Journal Article] Acceleration of bone formation with BMP2 in frame-reinforced carbonate apatite-collagen sponge scaffolds.2007

    • Author(s)
      Hirata I., Nomura Y., Ito M., Shimazu A., Okazaki M
    • Journal Title

      J Artif Organs 10

      Pages: 212-217

    • Peer Reviewed
  • [Journal Article] Cell adhesion and proliferation patterns on mixed self-assembled monolayers carrying various ratios of hydroxyl and methyl groups.2007

    • Author(s)
      Fuse Y., Hirata I., Kurihara H., Okazaki M
    • Journal Title

      Dent Mater J 26

      Pages: 814-819

    • Peer Reviewed
  • [Journal Article] Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials.2007

    • Author(s)
      Hamada Y., Egusa H., Kaneda Y., Hirata I., Kawaguchi N., Hirao T., Matsumoto T., Yao M., Daito K., Suzuki M., Yatani H., Daito M., Okazaki M., Matsuura N
    • Journal Title

      Dent Mater J 26

      Pages: 487-492

    • Peer Reviewed
  • [Presentation] シンポジウム7「ティッシュエンジニアリング」炭酸アパタイト・コラーゲンスカフォールドの骨再生能に関するコンセプト2010

    • Author(s)
      岡崎正之
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島(広島国際会議場)
    • Year and Date
      2010-03-18
  • [Presentation] 異なるSAM表面上へのハイドロキシアパタイトのアフィニティー析出2009

    • Author(s)
      岡崎正之, 平田伊佐雄
    • Organizer
      日本バイオマテリアル学会
    • Place of Presentation
      京都(京都テルサ)
    • Year and Date
      2009-11-16
  • [Presentation] 各種炭酸アパタイト・コラーゲンスカフォールドの骨再生能2009

    • Author(s)
      岡崎正之, 平田伊佐雄
    • Organizer
      第47回日本人工臓器学会
    • Place of Presentation
      新潟(朱鷺メッセ)
    • Year and Date
      2009-11-13
  • [Presentation] Biological interface reaction of CO3Ap-collagen composites.2009

    • Author(s)
      M. Okazaki
    • Organizer
      Composite at Lake Louise 2009
    • Place of Presentation
      Lake Louise, Canada
    • Year and Date
      2009-10-28
  • [Presentation] 新規バイオミメティック骨移植材の骨形成能2009

    • Author(s)
      松浦歩, 久保隆靖, 土井一矢, 平田伊佐雄, 岡崎正之, 赤川安正
    • Organizer
      第54回日本歯科理工学会
    • Place of Presentation
      鹿児島(かごしま県民交流センター)
    • Year and Date
      2009-10-02
  • [Presentation] Interface Affinity between Apatites and Biological Tissues.2009

    • Author(s)
      Okazaki M
    • Organizer
      The 3rd International Symposium for Interface Oral Health Science
    • Place of Presentation
      Sendai (Tohoku University)
    • Year and Date
      2009-01-16
  • [Presentation] シンポジウム8バイオマテリアルとしての新規材料:アパタイトに秘められた可能性を探る2008

    • Author(s)
      岡崎正之
    • Organizer
      日本バイオマテリアルシンポジウム2008
    • Place of Presentation
      東京(東京大学)
    • Year and Date
      2008-11-17
  • [Presentation] Bone Formation Ability of CO3Ap-collagen Sponge Scaffolds with Cytokine.2008

    • Author(s)
      Okazaki M., Hirata I
    • Organizer
      ISACB2008
    • Place of Presentation
      Manila, Philippines (Edsa Shangri-La)
    • Year and Date
      2008-09-12
  • [Presentation] Promoted Bone Formation in Frame-Reinforced CO3Ap-Collagen Composites with BMP22008

    • Author(s)
      Okazaki M., Hirata I
    • Organizer
      WBC
    • Place of Presentation
      Amsterdam, Netherland (RAI Convention Center)
    • Year and Date
      2008-05-31
  • [Presentation] シンポジウム13「アパタイトを基盤とした歯科領域の再生医療」.アパタイト無くして歯や骨は語れない2007

    • Author(s)
      岡崎正之
    • Organizer
      第29回日本バイオマテリアル学会
    • Place of Presentation
      大阪(千里ライフサイエンスセンター)
    • Year and Date
      2007-11-26
  • [Presentation] 平成19年度学会賞受賞講演「アパタイト合成法の確立と生体材料への応用」2007

    • Author(s)
      岡崎正之
    • Organizer
      第29回日本バイオマテリアル学会
    • Place of Presentation
      大阪(千里ライフサイエンスセンター)
    • Year and Date
      2007-11-26
  • [Presentation] Bone formation ability of newly developed CO3Ap-collagen sponges.2007

    • Author(s)
      Matsuura A., Kubo T., Doi K., Hayashi K., Morita K., Hirata I., Okazaki M., Akagawa Y
    • Organizer
      International Dental Materials Congress 2007
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2007-11-24
  • [Presentation] Bone formation with reinforced CO3Ap-collagen scaffolds.2007

    • Author(s)
      Tieliewuhan Y., Hirata I., Okazaki M
    • Organizer
      International Dental Materials Congress 2007
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2007-11-24
  • [Presentation] Development of highly functional hard tissue scaffold biomaterials.2007

    • Author(s)
      M. Okazaki
    • Organizer
      Composite at Lake Louise 2007
    • Place of Presentation
      Lake Louise, Canada
    • Year and Date
      2007-10-30
  • [Presentation] 骨芽細胞様細胞の炭酸アパタイト・コラーゲンスポンジ上での細胞活性2007

    • Author(s)
      赤松麻衣, 長尾雅美, 増西稔, 横田理絵, 林英貴, 平田伊佐雄, 岡崎正之
    • Organizer
      49回日本歯科理工学会
    • Place of Presentation
      札幌(札幌コンベンションセンター)
    • Year and Date
      2007-05-12
  • [Presentation] Roles of Trace Elements in Hydroxyapatite Crystals as Biomaterials.2006

    • Author(s)
      M. Okazaki, I. Hirata
    • Organizer
      Asian Bioceramics Symposium 2006
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2006-11-08
  • [Presentation] フレーム強化炭酸アパタイト・コラーゲンスカフォールドの骨形成能2006

    • Author(s)
      岡崎正之
    • Organizer
      第44回日本人工臓器学会
    • Place of Presentation
      横浜(パシフィコ横浜会議センター)
    • Year and Date
      2006-11-01
  • [Presentation] Biocompatibility of Mg-containing CO3Ap-collagen Composite as a Hard Tissue Biomaterial.2006

    • Author(s)
      M. Okazaki
    • Organizer
      The 11th IMgS2006, Kashikojima
    • Place of Presentation
      Japan (Invited lecture)
    • Year and Date
      2006-10-25
  • [Presentation] 硬組織バイオマテリアルの現状と将来展望2006

    • Author(s)
      岡崎正之
    • Organizer
      化学工学会第38回秋季大会シンポジウム<バイオメディカルマテリアルの最前線>「展望講演」
    • Place of Presentation
      福岡(福岡大学)
    • Year and Date
      2006-09-16
  • [Book] バイオマテリアルシリーズ3.セラミックバイオマテリアル2009

    • Author(s)
      岡崎正之, 山下仁大編著
    • Total Pages
      210
    • Publisher
      コロナ社
  • [Book] 2.セラミックス:ますます重要になる細胞周辺環境(細胞ニッチ)の最新科学技術(田端泰彦編)2009

    • Author(s)
      岡崎正之
    • Total Pages
      60-64
    • Publisher
      メディカルドゥ

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Published: 2011-06-18   Modified: 2016-04-21  

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