2007 Fiscal Year Final Research Report Summary
Development of the personalized health promotion program for the prevention of life-style related disease : Contribution of Cardiorespiratory Fitness and Obesity Genes to the Risk Factors of Metabolic Syndrome
| Project/Area Number |
18500559
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Waseda University |
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Principal Investigator |
SANADA Kiyoshi Waseda University, Consolidated Research Institute for Advanced Science and Medical Care, Associate professor (50421227)
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Mitsuru Waseda University, Faculty of Sports Science, Professor (20192289)
SUZUKI Katsuhiko Waseda University, Faculty of Human Science, Lecturer (80344597)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Obesity genes / Cardiorespiratory fitness / Metabolic syndrome / PPAR gamma / Maximal oxygen uptake / Genotype |
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| Research Abstract |
Little information is available regarding the relationships among human obesity-related genes, cardiorespiratory fitness and metabolic syndrome (MS) or predisposition to MS (MP). The purpose of this study was to investigate the contribution of obese-related genes and cardiorespiratory fitness to the MS in middle-aged and old men and women. Seven hundred fifty eight healthy men and women participated in this study. We measured maximal oxygen uptake (VO2max) during an incremental cycle ergometer exercise test. Serum BDL-cholesterol, triglyceride and plasma glucose levels were measured in all subjects. Total and regional lean soft tissue and fat mass were also measured by dual-energy X-ray absorptiometry (DXA). We analysed the genotype of b3-adrenergic receptor (ADRB3 64 T>A), peroxisome proliferator-activated receptor gamma (PPARG 1431 C>. Pro12Ala), uncoupling protein 1(UCP1 3826 A>G), and fatty acid-binding protein 2(FABP2 54 A>T) using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Significant associations were observed between VO2max less than 32 nil/kg/min in men and 30 ml/kg/min in women and increases in the number of risk factors of MS (P<0.05). Poor VO2max was associated with the prevalence of MS in men and women independently of the 1431 C>T polymorphism in PPAR_Y. It is important to maintain high cardiorespiratory fitness regardless of the obesity gene variance for the prevention of metabolic syndrome.
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[Journal Article] Muscle Mass and Bone Mineral indices : Does the Normalised Bone Mineral Content Differ with Age?
Author(s)
Kiyoshi Sanada, Motohiko Miyachi, Izumi Tabata, Masae Miyatani, Tanimoto Michiya, Tae-woong Oh, Kenta Yamamoto, Chiyoko Usui, Hiroshi Kawano, Eri Takahashi, Yuko Gando, Mitsuru Higuchi
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Journal Title
Eur J Clin Nutr (In press)
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Greater Age-related Arterial Stiffening and Left Ventricular Hypertrophy in Poor Cardiorespiratory Fitness Women.2007
Author(s)
Gando Y, Miyachi M, Kawano H, Sanada K, Yamamoto K, Tanimoto M, Oh T, Omori Y, Miyatani M, Usui C, Takahashi E, Tabata I, Higuchi M.
Organizer
54th Annual Meeting of the American College of Sports Medicine
Place of Presentation
New Orleans
Year and Date
20070600
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Age, flexibility, and metabolic syndrome.2007
Author(s)
Miyachi M, Sanada K, Yamamoto K, Kawano H, Gando Y, Tanimoto M, Oh T, Ohmori Y, Higuchi M, Tabata I.
Organizer
54th Annual Meeting of the American College of Sports Medicine
Place of Presentation
New Orleans
Year and Date
20070600
Description
「研究成果報告書概要(欧文)」より
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