2009 Fiscal Year Final Research Report
Survey of candidate molecules relevant to diabetic angiopathy
| Project/Area Number |
18500641
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
FUKATSU Kayoko (佐々木 佳世子) National Institute of Advanced Industrial Science and Technology, 農学部, 客員准教授 (70338903)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Hideyo 山形大学, 農学部, 准教授 (60235380)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 血管障害 / 糖尿病 / 酸化ストレス / 培養細胞 / グルタチオン |
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| Research Abstract |
To investigate the novel candidate molecules involved in the cause of diabetic angiopathy, we used cultured human umbilical vein endothelial cells (HUVEC). In living HUVEC that was exposed to high glucose, antioxidant ability via the GSH cycle was remarkably reduced. The possibility was suggested that glycation of glutathione is responsible for this reduction. Two glycated glutathiones, whose N-position and S-position was respectively modified, were synthesized, and their coenzyme activities for antioxidative enzyme via GSH system were decreased. Further studies in this line would contribute to actual medical treatment in future.
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