2008 Fiscal Year Final Research Report
Total synthesis of Salinosporamide A, a potent proteasome inhibitor
| Project/Area Number |
18590023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
SHIRAI Ryuichi Doshisha Women's College of Liberal Arts, 薬学部, 教授 (80183838)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMAZAWA Rumiko 同志社女子大学, 薬学部, 専任講師 (00411083)
KURIYAMA Masami 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (40411087)
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| Project Period (FY) |
2006 – 2008
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| Keywords | Salinosporamide A / プロテアソーム / ピペラジン / 不斉非対称化 / 不斉合成 / 全合成 / 1,2-ジオール / 1,3-ジオール |
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| Research Abstract |
Asymmetric desymmetrizations of σ-symmetric 1, 2-diols and 1, 3-diols were successfully achieved with newly developed C_2-symmetric piperadine-type chiral diamine, DMPP.Furthermore a key intermediate for the total synthesis of Salinosporamide A was synthesized in high optical yield by means of the desymmetrization of σ-symmetric 1,3-diol with DMPP-CuCl_2 complex and benzoyl chloride.
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