2009 Fiscal Year Final Research Report
Study on molecular basis of expression and structure of complement component C1s/C1r/C1r-LP
| Project/Area Number |
18590634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Tottori University |
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Principal Investigator |
NAKAGAWA Mayumi Tottori University, 医学部, 助教 (00243410)
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| Co-Investigator(Kenkyū-buntansha) |
YUASA Isao 鳥取大学, 医学部, 准教授 (00093633)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 補体 / 遺伝子多型 / 遺伝子多様性 |
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| Research Abstract |
The human genes for complement components C1s,C1s and C1r-LP are closely located on chromosome 12 and are structurally similar to each other. C1S/C1R genes were generated from a common ancestral gene and C1r-LP gene was generated by C1R gene duplication. In this study, we clarified the coding exon organization of non-human primate C1S and C1R genes, and it was shown that each gene has gone through a similar evolutionary rate in primate after gene duplication.
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