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2009 Fiscal Year Final Research Report

The role of TEL in embryonic stem cell differentiation, and identification of a new interacting protein.

Research Project

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Project/Area Number 18591085
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionEhime University (2008-2009)
Dokkyo Medical University (2006-2007)

Principal Investigator

EGUCHI Mariko  Ehime University, 医学部・附属病院, 講師 (40420781)

Co-Investigator(Kenkyū-buntansha) EGUCHI Minenori  愛媛大学, 医学系研究科, 講師 (50420782)
YAMAGATA Tetsuya  獨協医科大学, 医学部, 准教授 (30424047)
MAKI Kazuhiro  獨協医科大学, 医学部, 講師 (50337391)
SASAKI Ko  獨協医科大学, 医学部, 講師 (60282638)
Project Period (FY) 2006 – 2009
KeywordsTEL / ETV6 / TEL-TRKC / 転写因子 / 造血細胞分化 / ES細胞
Research Abstract

Murine embryonic stem (ES) cells expressing wild type TEL and TEL-TRKC fusion gene, identified as an oncogenic factor in both leukemia and infantile fibrosarcoma, were established. The ES cells were differentiated into hematopoietic cells and analyzed in detail to clarify its function necessary for tumorigenesis. ES cells expressing wild type TEL had the tendency to remain in immature hematopoietic cells, whereas TEL-TRKC expressing ES cells could not differentiate into hemangioblast, a common precursor of endothelial and blood cells, and their capacity to produce hematopoietic stem cells were severely impaired. Mesoderm derived, immature cells increased instead of blood cells, which might be the cancer stem cells for TEL-TRKC harboring fibrosarcoma. Interacting protein to TEL is now being investigated for its association with tumorigenesis.

  • Research Products

    (16 results)

All 2009 2008 2007 2006

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (6 results)

  • [Journal Article] 特集小児疾患における臨床遺伝学の進歩各論III. 話題の疾患遺伝子乳児白血病2009

    • Author(s)
      江口真理子、石前(江口)峰斉、石井榮一
    • Journal Title

      小児科 50巻7号

      Pages: 1093-1099

  • [Journal Article] Leukemia-related transcription factor TEL/ETV6 expands erythroid precursors and stimulates hemoglobin synthesis.2009

    • Author(s)
      M. Eguchi-Ishimae, M. Eguchi, K. Maki, C. Porcher, R. Shimizu, M. Yamamoto, K. Mitani
    • Journal Title

      Cancer Sci 100巻4号

      Pages: 689-697

    • Peer Reviewed
  • [Journal Article] Enhanced expression of the EVI1 gene in NUP98/HOXA-expressing leukemia cells.2009

    • Author(s)
      M. Eauchi-Ishimae, M. Eguchi, K. Ohyashiki, T. Yamagata, K. Mitani
    • Journal Title

      Int J Hematol 89巻2号

      Pages: 253-256

    • Peer Reviewed
  • [Journal Article] Clinical features and outcome of MLL gene rearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation.2008

    • Author(s)
      H. Tauchi, D. Tomizawa, M. Eguchi, Eguchi-Ishimae, K. Koh, M. Hirayama, N. Miyamura, N. Kinukawa, Y. Hayashi, K. Horibe, E. Ishii
    • Journal Title

      Leuk Res 32巻10号

      Pages: 1523-1529

    • Peer Reviewed
  • [Journal Article] NOTCH1 mutation can be an early, prenatal genetic event in T-ALL.2008

    • Author(s)
      M. Eguchi-Ishimae, M. Eguchi, H. Kempski, M. Greaves
    • Journal Title

      Blood 111巻1号

      Pages: 376-378

    • Peer Reviewed
  • [Journal Article] Outcome of risk-based therapy for infant acute lymphoblastic leukemia with or without an MLL gene rearrangement, with emphasis on late effects: a final report of two consecutive studies, MLL96 and MLL98, of the Japan Infant Leukemia Study Group.2007

    • Author(s)
      D. Tomizawa, K. Koh, T. Sato, N. Kinukawa, A. Morimoto, K. Isoyama, Y. Kosaka, T. Oda, M. Oda, Y. Hayashi, M. Eguchi, K. Horibe, T. Nakahata, S. Mizutani, E. Ishii
    • Journal Title

      Leukemia 21巻11号

      Pages: 2258-2263

    • Peer Reviewed
  • [Journal Article] 染色体・遺伝子異常からみる造血器腫瘍2007

    • Author(s)
      江口真理子
    • Journal Title

      人類遺伝学会第14回臨床細胞遺伝セミナーテキスト

      Pages: 45-57

  • [Journal Article] Chronic idiopathic myelofibrosis expressing a novel type of TEL-PDGFRB chimaera responded to imatinib mesylate therapy.2007

    • Author(s)
      K. Tokita, K. Maki, J. Tadokoro, Y. Nakamura, Y. Arai, K. Sasaki, M. Eguchi-Ishimae, M. Eguchi, K. Mitani
    • Journal Title

      Leukemia 21巻1号

      Pages: 190-192

    • Peer Reviewed
  • [Journal Article] MLL chimeric protein activation renders cells vulnerable to chromosomal damage: an explanation for the very short latency of infant leukemia.2006

    • Author(s)
      M. Eguchi, M. Eguchi-Ishimae, D. Knight, L. Kearney, R. Slany, M. Greaves
    • Journal Title

      Genes Chromosomes Cancer 45巻8号

      Pages: 754-760

  • [Journal Article] 特集・慢性骨髄増殖疾患と後天性遺伝子異常~真性赤血球増加症とJak2を中心に~4・慢性骨髄増殖疾患とTEL-チロシンキナーゼ異常2006

    • Author(s)
      江口真理子、石前(江口)峰斉
    • Journal Title

      血液フロンティア 16巻

      Pages: 397-407

  • [Presentation] HDR症候群に認められたGArA3遺伝子の新規変異とその機能解析2009

    • Author(s)
      江口真理子、石前(江口)峰斉、岩蕗秀彦、太田雅明、村尾紀久子、竹本幸司、石井榮一
    • Organizer
      第54回日本人類遺伝学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-24
  • [Presentation] 白血病関連転写因子TELは赤芽球系前駆細胞を増加させる2007

    • Author(s)
      江口真理子、石前(江口)峰斉、牧和宏、清水律子、山本雅之、三谷絹子
    • Organizer
      第69回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-11
  • [Presentation] 7;11転座におけるHoxA遺伝子とそのcofhctorの発現2007

    • Author(s)
      石前(江口)峰斉, 江口真理子, 大屋敷純子, 大屋敷一馬, 三谷絹子
    • Organizer
      第69回日本血液学会総会・第49回臨床血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-11
  • [Presentation] Leukemia-related transcription factor TEL expands erythroid precursors.2007

    • Author(s)
      Minenori Eguchi-Ishimae, Mariko Eguchi, Kazuhiro Maki, Ritsuko Shimizu, Masayuki Yamamoto, Kinuko Mitani
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
  • [Presentation] MLL融合遺伝子によりDNA damageが蓄積する2006

    • Author(s)
      江口真理子、石前(江口)峰斉、三谷絹子、Robert Slany, Mel Greaves
    • Organizer
      第68回日本血液学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2006-10-08
  • [Presentation] T-ALLにおけるNotchl遺伝子変異は胎生期に形成される.2006

    • Author(s)
      石前(江口)峰斉, 江口真理子, 三谷絹子, Helena Kempski, MelGreaves
    • Organizer
      第68回日本血液学会総会・第48回臨床血液学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2006-10-07

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Published: 2011-06-18   Modified: 2012-08-22  

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