2009 Fiscal Year Final Research Report
Analysis of RUNX1-target genes and their functions
| Project/Area Number |
18591086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
YAMAGATA Tetsuya Dokkyo Medical University, 医学部, 准教授 (30424047)
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| Co-Investigator(Renkei-kenkyūsha) |
MAKI Kazuhiro 獨協医科大学, 医学部, 講師 (50337391)
SASAKI Ko 獨協医科大学, 医学部, 講師 (60282638)
MITANI Kinuko 獨協医科大学, 医学部, 教授 (50251244)
EGUCHI Mariko 獨協医科大学, 医学部, 講師 (40420781)
EGUCHI Minenori 獨協医科大学, 医学部, 講師 (50420782)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 血液内科学 |
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| Research Abstract |
We have found that microRNA-9 (mir-9), one of miRNAs that regulates RUNX1 protein translation, is over-expressed in the bone marrow cells of nearly 15% of acute myelogenous leukemia AML patients. The mir-9-expressing AML patients show short remission-free survival and short overall survival than the non-expressing AML patients. Thus, the over-expression of mir-9 may cause aggressive form of AML through suppressing the translation of RUNX1 and hence its function, which leads to the aberrant expression of its target genes.
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