2007 Fiscal Year Final Research Report Summary
IMAGING OF NEUROREGENERATION PROCESS USING MOLECULAR MR IMAGING
| Project/Area Number |
18591616
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Meiji College of Oriental Medicine |
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Principal Investigator |
TANAKA Chuzo Meiji College of Oriental Medicine, SCHOOL OF HEALTH SCIENCES AND MEDICAL CARE, PROFESSOR (80163541)
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Toshihiro MEIJI UNIVERSITY OF ORIENTAL MEDICINE, SCHOOL OF HEALTH SCIENCES AND MEDICAL CARE, PROFESSOR (80218700)
UMEDA Masahoro MEIJI UNIVERSITY OF ORIENTAL MEDICINE, SCHOOL OF HEALTH SCIENCES AND MEDICAL CARE, PROFESSOR (60223608)
AOKI Ichio National Institute of Radiological Sciences, Biophysics Group, Molecular Imaging Center, MR Molecular Imaging Team, Team Leader (10319519)
WTANABE Yasuharu MEIJI UNIVERSITY OF ORIENTAL MEDICINE, SCHOOL OF HEALTH SCIENCES AND MEDICAL CARE, PROFESSOR (90454537)
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| Project Period (FY) |
2006 – 2007
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| Keywords | manganese enhanced MRI / AIM-MRI / molecular imaging / neural regeneration / cerebral infarction / gliosis / transient cerebral ischemia / hippocampus |
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| Research Abstract |
In this study, molecular MR imaging has been developed using manganese enhanced brain imaging. Activity-Induced Manganese-dependent (AIM) MRI was introduced in fMRI as method independent of hemodynamic changes. 1) Though systemic administration of MnC1 always showed enhanced hypocampal structures such as CA1, CA2, and dentate gyrus. We could not show the decreased signal change in CA1 layer at transient cerebral ischemia using rat cardiac arrest model. Our study has performed using a 7 tesla MR apparatus to improve the signal noise ratio of MR images. 2) From histological examination, we could obtained apoptotic changes in CA1 cells in acute stage and increased glial cells in chronic stage. 2) Using this model, a water maze test could not show the behavior difference between transient ischemia rats and control rats except very acute stage in cerebral ischemia. 3) Though systemic administration of MnC12 always showed enhanced spinal cord, in the case of rat spinal injury model, contused spinal cord has not been enhanced in any stages. This model was useful to analyze acute spinal cord injury and its recovery stage.
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[Journal Article] Toward a common circle : interhemispheric contextual modulation in human early visual areas.2006
Author(s)
Ban, H., Yamamoto, H., Fukunaga, M., Nakagoshi, A., Umeda, M., Tanaka, C., Ejima, Y
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Journal Title
The Journal of Neuroscience 26
Pages: 8804-8809
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 「研究成果報告書概要(欧文)」より2007
Author(s)
Kawai Y, Aoki I, Matsumoto N, Umeda U, Higuchi T, Kershaw J, Silva AC, Tanaka C : Detection of Reactive Gliosis Using Manganese-Enhanced MRI(MEMRI).
Organizer
ISMRM 15th scientific meeting
Place of Presentation
Berlin, Germany
Year and Date
20070000
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[Presentation] MR分子イメージング2006
Author(s)
田中 忠蔵
Organizer
第13回光医療産業バレー研究会
Place of Presentation
京都
Year and Date
2006-10-18
Description
「研究成果報告書概要(和文)」より
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