• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2009 Fiscal Year Final Research Report

The remodeling of the pulmonary artery in Nitrofen-induced diaphragmatic hernia

Research Project

  • PDF
Project/Area Number 18591951
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionTokyo Women's Medical University

Principal Investigator

KOUCHI Katsunori  Tokyo Women's Medical University, 医学部, 准教授 (40312938)

Project Period (FY) 2006 – 2009
Keywords胎児 / 横隔膜ヘルニア / 肺高血圧
Research Abstract

In Nitrofen-induced congenital diaphragmatic hernia (CDH) fetal rat, the expression of agiopetin-1was low and the ET1, ET1 recepter A/B was high. The other genes ; VEGF、angiopoietin-2、ephrinA1,B2、PDGFb and their receptor was no alternation compared with normal fetal rat. This suggested that over expression of ET1 and its receptor A/B induced the wall thickness of CDH fetal rat. Therefore, We examined the effect of ET receptor antagonist to feta dam. Pregnant rat gavaged ET1 antagonist. In these dam, the thickness of the pulmonary artery was not observed and the expression of VEGF was increased. In the other gene expression were not altered. In conclusion : ET receptor antagonist increased the expression of VEGF and reduced the wall thickness of the pulmonary artery in CDH dam. We supposed the high expression of VEGF made the prevention of the wall thickness. ET receptor antagonist has effect to prevent the pulmonary hypertension in newborn CDH.

  • Research Products

    (1 results)

All 2008

All Presentation (1 results)

  • [Presentation] ラット横隔膜ヘルニアモデルを用いた血管形成の分子生物学的検討とEndothelin1阻害薬による肺動脈壁肥厚の抑制2008

    • Author(s)
      幸地克憲、松浦玄、吉田英生、菱木知郎、齋藤武、照井慶太
    • Organizer
      第45回日本小児外科学会
    • Place of Presentation
      筑波(シンポジウム)
    • Year and Date
      20080528-20080530

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi