2009 Fiscal Year Final Research Report
Strategy for treatment of septic shock by poly (ADP-ribose) synthetase inhibitor
| Project/Area Number |
18591978
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MITAKA Chieko Tokyo Medical and Dental University, 医歯学総合研究科, 准教授 (20126254)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 敗血症性ショック / エンドトキシンショック / Poly (ADP-ribose) synthetase / 炎症性サイトカイン |
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| Research Abstract |
To investigate a strategy for treatment of septic shock, we administered 3-aminobenzamide, poly (ADP-ribose) synthetase inhibitor, in rat endotoxic shock model. 3-aminobenzamide reduced systemic inflammatory response and improved hemodynamics. These findings suggest that poly (ADP-ribose) synthetase plays an important role in mechanism of septic shock.
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