2009 Fiscal Year Final Research Report
The prevention of Alzheimer's disease by masticatory organ
| Project/Area Number |
18592149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
KIMOTO Katsuhiko Kanagawa Dental College, 歯学部, 教授 (70205011)
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| Co-Investigator(Kenkyū-buntansha) |
LEE MasaichiーC. 神奈川歯科大学, 歯学部, 教授 (60220795)
YOSHINO Fumihiko 神奈川歯科大学, 歯学部, 講師 (20308307)
AOKI Hiromichi 神奈川歯科大学, 歯学部, 講師 (50350533)
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| Co-Investigator(Renkei-kenkyūsha) |
HORI Norio 神奈川歯科大学, 歯学部, 講師 (20386832)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 咬合干渉 / 海馬 / 活性酸素種(ROS) / 軟性食餌 / MC-PROXYL / ESR / 咀嚼不全 |
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| Research Abstract |
The aim of this study examined the effects of dysfunctional mastication such as occlusal interference and soft-food diets on oxidative stress in the brain, and the relationship between these effects and dopamine (DA) levels. Electron spin resonance (ESR) studies using the nitroxyl spin probe 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl directly demonstrated a high level of oxidative stress in the rat brain due to dysfunctional mastication. In addition, we confirmed that DA directly reacts with reactive oxygen species such as hydroxyl radical and super oxide in vitro. These observations suggest that dysfunctional mastication enhances oxidative stress, which leads to oxidation and a decrease in the release of DA in the hippocampus of rats.
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