2007 Fiscal Year Final Research Report Summary
Bone regeneration for secondary bone graft and orthodontic evaluation
| Project/Area Number |
18592231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUSAMI Takafumi The University of Tokyo, Faculty of Medicine, Associate Professor (80179184)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATO Tsuyoshi The University of Tokyo, Faculty of Medicine, Professor (90171454)
HOSHI Kazuto The University of Tokyo, Faculty of Medicine, visiting Associate Professor (30344451)
OGASAWARA Toru The University of Tokyo, Faculty of Medicine, Lecturer (20359623)
MATSUZAKI Masako The University of Tokyo, Faculty of Medicine, Assistant Professor (80313154)
OHASHI Katsumi The University of Tokyo, Faculty of Medicine, Assistant Professor (60233235)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Bone Metabolism / Bone Regenerative Medicine / Dentistry |
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| Research Abstract |
The purposes of this study were ; (1) how to make tissue-engineered bone to be used in secondary bone graft for CLP patients and ; (2) to establish the system(s) to evaluate such application from an orthodontic viewpoint.
First, we checked the expression levels of Nanog gene, which is essential to self-renewal of embryonic stem(ES) cells, among mesenchymal cells by performing RTPCR. There was not detectable level of Nanog gene among them. Next Nanog gene was introduced to mesenchymal cells with retrovirus vector aiming at improving osteogenic differentiation. As a result, forced Nanog expression could promote osteogenic differentiation of mesenchymal cells. At the same time, forced expression of Nanog caused stimulation of Smad1/5/8 which transmits BMP signal, and inhibition of STAT3 which plays an important role in self-renewal of ES cells. From these results, we concluded that elucidation of the role of Nanog in osteogenic differentiation may be useful for understanding bone metabolism and bone regenerative medicine. (157 words)
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[Journal Article] Growth Factor Contents of Autologous Human Sera Prepared by Different Production Methods and Their Biological Effects on Chondrocytes2008
Author(s)
Tanaka, Y., Ogasawara, T., Asawa, Y., Yamaoka, H., Nishizawa, S., Mori, Y., Takato. T., and Hoshi, K.
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Journal Title
Cell Biology International (in press)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cyclooxygenase-2 Activity is essential for the Osseointegration of Dental Implants2007
Author(s)
Chikazu, D., Tomizuka, K., Ogasawara, T., Saijo, H., Koizumi, T., Mori, Y., Yonehara, Y., Susami, T. and Takato, T.
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Journal Title
Int J Oral Maxillofac Surg 36
Pages: 441-446
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes2007
Author(s)
Liu, G., Kawaguchi, H., Ogasawara, T., Asawa, Y., Kishimoto, J. I., Takahashi, T., Chung, U. I., Yamaoka, H., Asato, H., Nakamura, K., Takato. T. and Hoshi. K.
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Journal Title
J Biol Chem 282
Pages: 20407-20415
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Three-dimensional microenvironments retain chondrocyte phenotypes during proliferation culture2007
Author(s)
Takahashi, T., Ogasawara, T., Asawa, Y., Mori, Y., Uchinuma, E., Takato, T. and Hoshi. K.
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Journal Title
Tissue Engineering 13
Pages: 1583-1592
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Assessment of dental arch relationships using the 5-Year-Old Index in Japanese patients with unilateral cleft lip and palate2007
Author(s)
Susami, T., Toriyama, H., Wada, M., Okunbo, K, Matsuzaki, M., Nakasone, A., Ogihara, Y., Mori, Y., Yonehara, Y., and Takato. T.
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Journal Title
J Jpn Cleft Palate Assoc 32
Pages: 34-42
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Assessment of dental arch relationships using the 5-Year-Old Index in Japanese patients with unilateral cleft lip and palate who underwent earlier secondary cleft closure2007
Author(s)
Hirano, Y., Kohara, H., Yokota, Y., Kobayashi, C., Nishio, J., and Susami, T.
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Journal Title
J Jpn Cleft Palate Assoc 32
Pages: 68-77
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Segmental alveolar distraction for the correction of unilateral open-bite caused by multiple ankylosed teeth : A case report2006
Author(s)
Susami, T., Matsuzaki. M., Ogihara, Y., Sakiyama, M., Takato, T., Sugawara, Y. and Matsumoto, S.
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Journal Title
J Ortbod 33
Pages: 153-159
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Assessment of dental arch relationships in Japanese patients with unilateral cleft lip and palate2006
Author(s)
Susami, T., Ogihara, Y., Matsuzaki M., Sakiyama, M., Takato, T., Shaw, W. C. and Semb, G.
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Journal Title
Cleft Palate Craniofac J 43
Pages: 96-102
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A 2-stage procedure combining maxillary advancement by distraction technique with mandibular setback surgery in patients with cleft lip and palate2006
Author(s)
Mori, Y., Eguchi, T., Matsuzaki. M., Ogihara, Y., Susami, T., Chikazu, D., Saijo, H., Yonehara, Y. and Takato, T.
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Journal Title
Int J Oral Madllofac Surg 35
Pages: 594-597
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cartilage tissue engineering using human auricular chondrocytes embedded in different hydrogel materials2006
Author(s)
Yamaoka, H., Asato, H., Ogasawara, T., Nishizawa, S., Takahashi, T., Nakatsuka, T., Koshima, I., Nakamura, K., Kawaguchi, H., Chung, U-I, Takato, T., and Hoshi K
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Journal Title
J Biomed Mater Res A 78
Pages: 1-11
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Application of Cell Cycle Factors to Bone Regeneration2007
Author(s)
Ogasawara T., Hoshi K., Kawaguchi H., Ohba S., Chikazu D., Fujihara Y., Suenaga H., Mori Y., Susami T., Okayama H., Takato T.
Organizer
TERMIS-AP 2007
Place of Presentation
Tokyo.
Year and Date
20071203-05
Description
「研究成果報告書概要(欧文)」より
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[Presentation] A new thienoindazole derivative promotes chondrogenic differentiation via Runxl, co-activator of Sox5, Sox6 and Sox9(the Sox trio)2007
Author(s)
Yano F., Ikeda T., Saito T., Ogata N., Ogasawara T., Kimura A., Takeda S., Nakamura K., Kawaguchi H., Takato T., Chung UI.
Organizer
TERMIS-AP 2007
Place of Presentation
Tokyo.
Year and Date
20071203-05
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Minuscule Tetrapod-Shape Bone Filler2007
Author(s)
Igawa K., Tomizuka K., Ohba S., Ogasawara T., Chikazu D., Mori Y., Takato T., Chung U. I
Organizer
AAOMS 89th Annual Meeting, Scientific Sessions & Exhibition In conjunction with the JSOMS and KAOMS
Year and Date
20071008-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Minuscule Tetrapod-Shape Bone Filler2007
Author(s)
Igawa K., Tomizuka K., Ohba S., Ogasawara T., Chikazu D., Mori Y., Takato T., Chung U. I.
Organizer
The 52nd Annual Meeting of the Japanese Society of oral and maxillofacial Surgeon
Place of Presentation
Nagoya.
Year and Date
20070929-30
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Assessment of long-term follow-up of patients with unilateral cleft who underwent secondary bone graft2007
Author(s)
Ohkubo K., Susami T., Matsuzaki M., Nakasone A., Mori Y., Yonehara Y., Chikazu D., Saijo H., Hasegawa Y., Tomizuka K., Oki M., Hikiji H., Takato T.
Organizer
The 31st Annual Meeting of Japanese Cleft Palate Association
Place of Presentation
Kusatsu.
Year and Date
20070524-25
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Optimization of Combinations of bone formation signaling and development of bone regenerative medicine without stem cells2006
Author(s)
Ohba S., Yano F., Igawa K., Fujihara Y., Ogasawara T., Chikazu D., Mori Y., Yonehara Y., Susami T., Chung U. I., Takato T.
Organizer
The 60th Annual Meeting of the Japanese Stomatological Society
Place of Presentation
Nagoya.
Year and Date
20060500
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Statistical Optimization of Combinations of Clinically-available Soluble Factors for Cartilage Tissue Engineering2006
Author(s)
Hoshi K., Liu G., Ogasawara T., Takahashi T., Asawa Y., Yamaoka H., Chung UI., Kawaguchi H., Nakamura K., Takato T
Organizer
World Congress of Tissue Engineering and Regenerative Medicine
Place of Presentation
Pittsburg, Pennsylvania, USA.
Year and Date
20060425-27
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Effects of TGF-β over chondrocytes used for Cartilage Tissue Engineering2006
Author(s)
Ogasawara T., Takahashi T., Asawa Y., Yamaoka H., Tanaka Y., Nishizawa s., Liu G., Yoda T., Susami T., Takato T., Hoshi K.
Organizer
The 5th Annual Meeting of the Japanese Society for Regenerative Medicine
Place of Presentation
Okayama.
Year and Date
20060308-09
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Comparison of unilateral cleft lip and palate treatments between several institutions2006
Author(s)
Asahito T., Ono K., Morita S., Mouri T., Takagi R.,Terao E., Kochi S., Susami T., Kurabayashi H., Iwata T., Tachimura S., Negoro T., Otsuka S., Saito I
Organizer
The 30th Annual Meeting of Japanese Cleft Palate Association
Place of Presentation
Hakuba
Year and Date
2006-05-25
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Assessment of occulusion and upper dental arch in patients at the age of five with unilateral cleft lip and palate who underwent two-step cleft closure2006
Author(s)
Kondo T., Sojo K., Fujii W., Aizawa T., Sato K., Tsujikawa T., Imamura M., Mizutani H., Iijima Y., Okumoto T., Yoshimura Y., Naito K., Shigeta R., Iizumi T., Inayoshi N., Susami T.
Organizer
The 30th Annual Meeting of Japanese Cleft Palate Association
Place of Presentation
Hakuba.
Year and Date
2006-05-25
Description
「研究成果報告書概要(欧文)」より
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[Book] 口と歯の辞典2007
Author(s)
須佐美隆史 ほか編集
Total Pages
206
Publisher
朝倉書店
Description
「研究成果報告書概要(和文)」より
