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2007 Fiscal Year Final Research Report Summary

The effect of antianxiety agent, saliva stimulant and gastric antisecretory activity on brux-like activity in rats

Research Project

Project/Area Number 18592249
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionKagoshima University

Principal Investigator

NAGATA Junko  Kagoshima University, Graduate School of Medical and Dental Sciences, School of dentistry, Department of Orthodontics & Dentofacial Orthopedics, Assistant Professor (50264429)

Co-Investigator(Kenkyū-buntansha) MIYAWAKI Shouichi  Kagoshima University Graduate School of Medical and Dental Sciences, School of dentistry, Department of Orthodontics & Dentofacial Orthopedics, Professor (80295807)
INUI Akio  Kagoshima University Graduate School of Medical and Dental Sciences, School of dentistry, Department of Psycosomatic Internal Medicine, Professor (80168418)
NAGATA Koji  Saitama medical university international medical center, Department of Pathology, Senior Assistant Professor (80398289)
KAMIMURA Hiroki  Kagoshima University Medical and Dental Hospital, reserch associate, Staff Physician (50464467)
Project Period (FY) 2006 – 2007
Keywordsrat / brux-like activity / emotional storess / sleep stage / electromyogram / electroencephalogram
Research Abstract

The aim of the present study was to investigate the relationship between the emotional stress and brux-like activity by comparison of the brain wave, activity of the masticatory muscles and expression frequency of the brux-like activity of rats those with emotional stress (emotional stress group) and without emotional stress (control group).
First, it was essential to investigate the sleep stage such as arousal and REM sleep stage. However, it has never been established to investigate the sleep stage of the rats automatically by the brain wave. We examined the effectiveness of the existing chronological data analysis software by investigation of the human brain wave data that has been already analyzed by the scientific operator who can determine the sleep stage. In the result, it was certified that the chronological data analysis software was useful to determine the depth and stage of the sleep automatically with high degree of accuracy.
Second, electrical pole screw was inserted to cranial bone of the 7-8 week-old Wister rats under general anesthesia and it was connected with copper line. Then, a needle electrode was inserted to the parietal region of the cranial bone through left side masseter muscle. These copper lines were connected with constantly embedded micro connecter and fixed to the parietal region. Brain wave, masseter muscle activity and electro-oculogram were developed using these devices.
Additionally, a catheter was inserted into external jugular vein and fixed to dorsal region of jacket through skin. Then, frequency and its change of brux-like activity were investigated when emotional stress was applied.
In the result, it was suggested that depth of sleep showed changes and the frequency of the brux-like activity increased when the emotional stress was applied. It was also suggested that premedication of antagonist drug to the emotional stress controled the increase of the brux-like activity.

  • Research Products

    (25 results)

All 2008 2007 2006 Other

All Journal Article (21 results) (of which Peer Reviewed: 6 results) Presentation (2 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Growth hormone relasing peptide 2 reverse anorexias associated with chemotherapy with 5-flurxiracil in colon cancer cell-bearing mice.2008

    • Author(s)
      Perboni S
    • Journal Title

      World J Gastroenterol 14

      Pages: 6303-6305

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motilityin in conscious rats.2008

    • Author(s)
      Fujimiya M
    • Journal Title

      World J Gastroenterol 14

      Pages: 6318-6326

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Growth hormone relasing peptide 2 reverse anorexia associated with chemotherapy with 5-fluoruracil in colon cancer cell-bearing mice.2008

    • Author(s)
      Perboni S, B owers C, Kojima S, Asakawa A, Inui A
    • Journal Title

      World J Gastroenterol 14

      Pages: 6303-6305

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats.2008

    • Author(s)
      Fujimiya M, Asakawa A, Ataka K, Kato I, Inui A
    • Journal Title

      World J Gastroenterol 14

      Pages: 6318-26

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 睡眠時ブラキシズムの関連因子2007

    • Author(s)
      宮脇正一
    • Journal Title

      心療内科 11(4)

      Pages: 278-284

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ブラキシズムと胃食道酸逆流2007

    • Author(s)
      宮脇正一
    • Journal Title

      Pharma Medica 25(2)

      Pages: 82-84

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Gastrointesutinal hormones (anorexigenic peptideYY and orxigen ghrelin)influence neural tube development.2007

    • Author(s)
      Yuzuriha H
    • Journal Title

      FASEB J 21

      Pages: 2108-2112

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Increased circulating cholecystokinin contributes to anorexia and anxiety behavior in mice overxppeessing pancreatic polypeptide.2007

    • Author(s)
      Ueno N
    • Journal Title

      Regul Pept 141

      Pages: 8-11

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Factors associated with sleep bruxism2007

    • Author(s)
      Miyawaki S, Nagata J, Ohmure H, Sakaguchi K, Maeda A, Togawa R, Fukunaga T
    • Journal Title

      Psychosomatic Medicine 11(4)

      Pages: 278-84

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Bruxism and gastroesophageal reflux.2007

    • Author(s)
      Miyawaki S, Nagata J, Ohmure H, Togawa R
    • Journal Title

      Pharma Medica 25(2)

      Pages: 82-84

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Gastrointesutinal hormones (anorexigenic peptideYY and orexigenic ghrelin) influence neural tube development.2007

    • Author(s)
      Yuzuriha H, Inui A, Asakawa A, Ueno N, Kasuga M, Meguid M, Miyazaki J, Ninomiya M, Herzog H, Fujimiya M
    • Journal Title

      FASEB J 21

      Pages: 2108-2112

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Increased circulating cholecystokinin contributes to anorexia and anxiety behavior in mice overexpressing pancreatic polypeptide.2007

    • Author(s)
      Ueno N, Asakawa A, Satoh Y, Inui A
    • Journal Title

      Regul Pept 141

      Pages: 8-11

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 小児期に多く認められるブラキシズム新たな消化器内科学的考え方について2006

    • Author(s)
      宮脇正一
    • Journal Title

      日本顎口腔機能学会雑誌 13(1)

      Pages: 16-20

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 睡眠時ブラキシズムの新たな関連因子嚥下と胃食道酸逆流2006

    • Author(s)
      宮脇正一
    • Journal Title

      鹿児島大学歯学部紀要 26

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficientobese ob/ob mice.2006

    • Author(s)
      Ueno N
    • Journal Title

      Peptides 27

      Pages: 2332-2342

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Sleep bruxism frequently observed in children ; New gastroenterological approach.2006

    • Author(s)
      Miyawaki S
    • Journal Title

      J. Jpn. Soc. Stomatognath. Func 13(1)

      Pages: 16-20

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] New factors associated with sleep bruxism; swallowing and gastroesophageal reflux.2006

    • Author(s)
      Miyawaki S
    • Journal Title

      Ann. Kagoshima Dent 26

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice.2006

    • Author(s)
      Ueno N, Inui A, Kalra PS, Kalra SP
    • Journal Title

      Peptides 27

      Pages: 2332-2342

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Their role in physiological body weight regulation and in the pathological state.2006

    • Author(s)
      Perboni S, Mantovani G, Inui A, Leptin, des-acyl ghrelin
    • Journal Title

      Cachexia and Wasting (Mantovani G, Anker SD, Inui A, Morley JE, Fanelli FR, Scevola D, Schuster MW, Yeh SS) (Springer-Verlag)

      Pages: 247-257

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Gastro-esophageal reflux symptoms in adult patients with skeletal Class III malocclusion as examined by questionnaire

    • Author(s)
      Togawa R
    • Journal Title

      Am J Orthod Dentofacial Orthop 1(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Gastro-esophageal reflux symptoms in adult patients with skeletal Class III malocclusion as examined by questionnaire.

    • Author(s)
      Togawa, R, Ohmure, H, Sakaguchi, K Takada H, Oikawa K, Nagata J, Yamamoto T, Tsubouchi H, Miyawaki S
    • Journal Title

      Am J Orthod Dentofacial Orthop (In press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Shitsumonshityousaniyoruisyokudousanngyakuryuusyounoumutokoukuushikkanntonokanren2007

    • Author(s)
      Togawa R, Nagata J, Ohmure H, Sakaguchi K, Nagayama K, Taira K, Mtsuda Y, Setoguchi T, Shimotabira T, Matsumoto J, Yamamoto T, Izumi Y, Fukunaga T, Miyawaki S
    • Organizer
      The 2nd Annual Meeting of Kyusyu Orthodontic Society
    • Place of Presentation
      Miyazaki
    • Year and Date
      20070217-20070218
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 質問紙調査による胃食道酸逆流症状の有無と口腔疾患との関連2007

    • Author(s)
      戸川玲奈
    • Organizer
      九州矯正歯科学会学術大会
    • Place of Presentation
      宮崎
    • Year and Date
      20070200
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Leptin and des-acyl ghrelin : Their role in physiological body weight regulation and in the pathological state.2006

    • Author(s)
      Perboni S
    • Total Pages
      10
    • Publisher
      Cachexia and Wasting, Springer-Verlag
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] 睡眠段階自動判定システム及び睡眠段階自動判定法2008

    • Inventor(s)
      宮脇正一, 永田順子, 上村裕希, 林列成, 篠崎毅, 千葉伸太郎, 八木朝子, 長濱博行, 城間清美
    • Industrial Property Rights Holder
      鹿児島大学, 株式会社ジー・エム・エス
    • Industrial Property Number
      A61B 5/04, 2008-318742
    • Filing Date
      2008-12-15
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-06-09  

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