2008 Fiscal Year Final Research Report
Design of immune tolerance inducing peptides and analysis of their allergy-suppressive effects
| Project/Area Number |
18780092
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | National Agricultural Research Organization (2008)
Hokkaido University (2006-2007) |
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Principal Investigator |
WATANABE Jun National Agricultural Research Organization, 食品総合研究所・食品機能研究領域, 主任研究員 (10374729)
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| Co-Investigator(Renkei-kenkyūsha) |
SONOYAMA Kei 北海道大学, 農学研究科, 准教授 (90241364)
ITO Susumu 北海道大学, 創成科学共同研究機構 (90400043)
TAGUCHI Hidenori 北海道大学, 創成科学共同研究機構, 特任助教 (60374732)
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| Project Period (FY) |
2006 – 2008
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| Keywords | 食物アレルギー / 経口免疫寛容 / 腸内細菌 / プレバイオティクス |
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| Research Abstract |
免疫寛容誘導物質の作製においては、低アレルゲン化小麦粉水溶性画分が免疫寛容誘導活性をもつことを明らかとし、活性本体のペプチドの単離を試みた。腸内細菌とアレルギー発症との関わりを調べ、Candida albicans の定着や幼少期の抗生物質投与による菌叢変化がアレルギーの増悪に関わること、難消化性オリゴ糖の摂取は菌叢変化を介してアレルギー発症に抑制的に作用することを示した。
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[Journal Article] Effects of epilactose on calcium absorption and serum lipid metabolism in rats.2008
Author(s)
Nishimukai, M., Watanabe, J., Taguchi, H., Senoura, T., Hamada, S., Matsui, H., Yamamoto, T., Wasaki, J., Hara, H., and Ito, S
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Journal Title
J. Agric. Food Chem. 56
Pages: 10340-10345
Peer Reviewed
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[Journal Article] Cloning and sequencing of the gene for cellobiose 2-epimerase form a ruminal strain of Eubacterium cellulosolvens.2008
Author(s)
Taguchi, H., Senoura, T., Hamada, S., Matsui, H., Kobayashi, Y., Watanabe, J., Wasaki, J., and Ito, S
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Journal Title
FEMS Microbiol. Lett. 287
Pages: 34-40
Peer Reviewed
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[Journal Article] Prebiotic properties of epilactose.2008
Author(s)
Watanabe, J., Nishimukai, M., Taguchi, H., Senoura, T., Hamada, S., Matsui, H., Yamamoto, T., Wasaki, J., Hara, H., and Ito, S.
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Journal Title
J. Dairy Sci. 91
Pages: 4518-4526
Peer Reviewed
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[Journal Article] Enzymatic properties of cellobiose 2-epimerase from Ruminococcus albus and the synthesis of rare oligosaccharides by the enzyme.2008
Author(s)
to, S., Taguchi, H., Hamada, S., Kawauchi, S., Ito, H., Senoura, T., Watanabe, J., Nishimukai, M., Ito, S., and Matsui, H.
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Journal Title
Appl. Microbiol. Biotechnol. 79
Pages: 433-441
Peer Reviewed
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[Journal Article] Cloning and sequencing of the cellobiose 2-epimerase gene from an obligatory anaerobe, Ruminococcus albus.2007
Author(s)
Ito, S., Hamada, S., Yamaguchi, K., Umene, S., Ito, H., Matsui, H., Ozawa, T., Taguchi, H., Watanabe, J., Wasaki, J., and Ito, S.
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Journal Title
Biochem. Biophys. Res. Commun. 360
Pages: 640-645
Peer Reviewed
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[Journal Article] Population dynamics of Bifodobacterium species in human feces during raffinose administration monitored by FISH-flow cytometry2006
Author(s)
Dinoto, A., Marques, T. M., Sakamoto, K., Fukiya, S., Watanabe, J., Ito, S., and Yokota, A.
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Journal Title
Appl. Environ. Microbiol. 72
Pages: 7739-7747
Peer Reviewed
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[Journal Article] Gastrointestinal Candida colonisation promotes sensitization against food antigens by affecting mucosal barrier in mice.2006
Author(s)
Yamaguchi, N., Sugita, R., Miki, A., Takemura, N., Kawabata, J., Watanabe, J., and Sonoyama, K.
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Journal Title
Peer Reviewed
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