2009 Fiscal Year Final Research Report
Function of Vascular Endothelial Growth Factor in inflammatory exacerbation
| Project/Area Number |
18791599
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
SHINO Kumiko Kagoshima University, 医学部・歯学部附属病院, 助教 (50325792)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 歯周病 / シグナル伝達 / 生体分子 |
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| Research Abstract |
VEGF-A_<121> induced activations of pro-MMP-9, pro-MMP-2, active-MMP-2 dose dependently in Human gingival fibroblast. The other side, VEGF-A 165 has no activation of them. From these results, VEGF-A_<121> may relate to periodontal inflammatory exacerbation. But in this study, VEGF doesn't show uPA up-regulation. Therefore, it suggested that activations of pro-MMP-9, pro-MMP-2, active-MMP-2 by VEGF-A_<121> relate to periodontal inflammatory exacerbation.
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