2010 Fiscal Year Final Research Report
Role of mammalian-specific genes related to genomic imprinting in mammalian development and evolution
| Project/Area Number |
18GS0315
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| Research Category |
Grant-in-Aid for Creative Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ISHINO Fumitoshi Tokyo Medical and Dental University, 難治疾患研究所, 教授 (60159754)
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| Co-Investigator(Kenkyū-buntansha) |
KANEKO Tomoko (石野 知子) 東海大学, 健康科学部, 教授 (20221757)
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| Co-Investigator(Renkei-kenkyūsha) |
KOHDA Takashi 東京医科歯科大学, 難治疾患研究所, 准教授 (60211893)
ONO Ryuichi 東京医科歯科大学, 難治疾患研究所, 助教 (10401358)
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| Project Period (FY) |
2006 – 2010
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| Keywords | ゲノム機能 / 哺乳類 / 胎生 / レトロトランスポゾン / 発生と進化 |
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| Research Abstract |
Sushi-ichi retrotransposon-derived genes (Sirh family genes) are mammalian-specific genes. Among them, we have previously reported that Peg10 and Peg11/Rtl1 play essential roles in placenta formation and function. In this project, we have produced knockout mice of each gene and demonstrated that Sirh7 has mammalian-specific functions concerning implantation and pregnancy as well as placenta formation. Our systematic analysis suggests that other Sirh genes also have such functions.
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