2010 Fiscal Year Final Research Report
Research for the mechanism of the expression of neuropathic pain
| Project/Area Number |
18GS0319
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| Research Category |
Grant-in-Aid for Creative Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Institution | Kyushu University |
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Principal Investigator |
INOUE Kazuhide Kyushu University, 大学院・薬学研究院, 教授 (80124379)
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| Co-Investigator(Kenkyū-buntansha) |
TSUDA Makoto 九州大学, 大学院・薬学研究院, 准教授 (40373394)
SAITOH Hidetoshi 九州大学, 大学院・薬学研究院, 助教 (90444794)
NAKATSUKA Terumasa 関西医療大学, 保健医療学部, 教授 (30380752)
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| Project Period (FY) |
2006 – 2010
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| Keywords | 脳神経疾患 / 痛み / シグナル伝達 / ミクログリア / アストロサイト |
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| Research Abstract |
We had already reported that activated microglia have a main role for evoking neuropathic pain which is resistant to morphine through the stimulation of P2X4 receptors after nerve damages (Nature, 2003 & 2005). In the present study, we tried to find how microglia receive information of nerve damage and cause the pain. It was clarified that microglia are activated through cytokines such as CCL21 released from the damage nerve, interferon-γ, PDGF. Moreover, transcription factor STAT3 was activated only in astrocytes after nerve damage that is very important for the evoking neuropathic pain.
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[Journal Article] JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.2011
Author(s)
M.Tsuda, Y.Kohro, T.Yano, T.Tsujikawa, J.Kitano, H.Tozaki-Saitoh, S.Koyanagi, S.Ohdo, R-R Ji, M.W.Salter, K.Inoue.
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Journal Title
Brain 134(4)
Pages: 1127-1139
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[Journal Article] Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kB
Author(s)
M.Nishida, M.Ogushi, R.Suda, M.Toyotaka, S.Saiki, N.Kitajima, M.Nakaya, K.-M.Kim, T.Ide, Y.Sato, K.Inoue, H.Kurose.
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Journal Title
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[Book] How DNA microarray technology contributes to the Retinoid Evaluations.(In "Vitamin A: New Research")(Ingrid T.Loesing)2007
Author(s)
Ishida S, Tanabe H, Shinozaki Y, Koyano S, Kagechika H, Shudo K, Ozawa S, Sawada J, Ohno Y, Inoue K.
Total Pages
71-92
Publisher
Nova Science Publishers, Inc.
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[Remarks] 2007年のNature論文は、NHK、毎日新聞、読売新聞や、共同通信社、西日本新聞などで紹介され、社会的なインパクトを与えた。
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[Remarks] 2008年2月19日に共同通信社が、我々の研究成果「抗うつ薬が動物でもヒトでも神経因性疼痛を抑制すること」を発信した。
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[Remarks] 2009年のProc.Natl.Acad.Sci.USA論文は、NHK、朝日新聞、毎日新聞、読売新聞、共同通信社、西日本新聞などで紹介され、社会的なインパクトを与えた。
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