2020 Fiscal Year Final Research Report
Development of Selective Oxidation Reactions Using Iodine Catalysis
| Project/Area Number |
18H01973
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 33020:Synthetic organic chemistry-related
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | 有機合成 |
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| Outline of Final Research Achievements |
Transition-metal-free and environmentally benign oxidative coupling reactions have been developed using designer iodine-based catalysis by taking advantage of the redox behavior of iodine as an alternative element to precious metals and/or heavy metals. Specifically, we used iodoarenes (for covalent-bonding catalysis) or quaternary onium iodides (for ion-pair catalysis) as catalysts and hydrogen peroxide or other common simple peroxides as oxidants.
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| Free Research Field |
有機化学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、貴金属や重金属の代替元素としてヨウ素の酸化・還元能を活かし、デザイン型ヨウ素化合物を有機分子触媒に用いる非金属系環境低負荷型酸化的カップリング反応及び不斉ヨウ素触媒の開発を目的とした。具体的には，触媒前駆体にはヨードアレーン（共有結合型触媒）または第四級オニウムヨウ化物（イオンペア型触媒）を、共酸化剤には過酸化水素や過酸化アルコールを用い、反応系に一切の毒性の強い物質を用いないことにした。
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