2020 Fiscal Year Final Research Report
How plants acquired the membrane trafficking system connecting inside and outside cells?
| Project/Area Number |
18H02470
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 44030:Plant molecular biology and physiology-related
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
Ueda Takashi 基礎生物学研究所, 細胞動態研究部門, 教授 (10311333)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | エンドサイトーシス / エキソサイトーシス / クラスリン / ANTHドメイン / シロイヌナズナ / ゼニゴケ / RAB GTPase |
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| Outline of Final Research Achievements |
Through functional analyses of endocytosis- and exocytosis-related molecules that have significantly diversified during land plant evolution, we attempted to elucidate the molecular mechanisms of membrane trafficking underpinning the plasma membrane function and reconstruct the evolutionary path of diversification of exocytic and endocytic trafficking. We found that the functions of the PICALM family, which act as clathrin adapters, have diversified during land plant evolution to play important roles in various developmental stages of plants, such as sexual reproduction and vegetative growth by being involved in endocytosis of distinct sets of proteins. We also found that RAB11 and RAB8, both of which are expected to act in the secretory pathway, may function by forming a cascade in a late step of secretion.
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| Free Research Field |
植物細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
細胞の内側から外側へ，あるいは外側から内側へと物質を輸送する仕組みは，生命を維持するために欠かせないものです．この仕組みは進化の過程でそれぞれの生物ごとに変化し，洗練されてきました．この研究では，この進化の過程を植物を用いて明らかにすることで，現在の植物細胞内の物質輸送の仕組みがどのように出来上がってきたのかを明らかにしました．
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