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2020 Fiscal Year Final Research Report

Pathophysiological functions via membrane progesterone receptors

Research Project

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Project/Area Number 18H02472
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 44040:Morphology and anatomical structure-related
Research InstitutionKyoto University (2020)
Tokyo University of Agriculture and Technology (2018-2019)

Principal Investigator

Ikuo Kimura  京都大学, 生命科学研究科, 教授 (80433689)

Project Period (FY) 2018-04-01 – 2021-03-31
Keywordsプロゲステロン / GPCR / 性ステロイドホルモン受容体 / MAPR / mPR
Outline of Final Research Achievements

Our study demonstrated that various physiological functions of sex steroid hormone via unknown mechanism partly involve non-genomic effects via membrane progesterone receptors. Further studies will proceed elucidation of molecular mechanism via sex steroid hormone-mediated non-genomic effects and understanding of systemic physiological functions, such as emotion, feeding, rhythm, sleep, memory, and learning, based on this mechanism.

Free Research Field

内分泌代謝学

Academic Significance and Societal Importance of the Research Achievements

本研究成果に基づいて、更にプロゲステロンの細胞膜上受容体の研究を進めることによって、性ステロイドホルモンの即時的反応の解明とそれに基づく生体機能調節機構の解明が可能になると予想される。そして、この研究は乳癌や不妊等の従来の性ステロイド関連疾患治療薬開発だけに留まらず、雌雄差、性差に関連した生活習慣病、睡眠・リズム障害の新規治療パラダイム発見の可能性と、さらにはそれからの美容・健康と化粧品の融合医学への新たな知見を提供すると期待される。

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Published: 2022-01-27  

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